scholarly journals A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 22700-22715 ◽  
Author(s):  
Ana Mato-Berciano ◽  
Giulia Raimondi ◽  
Maria Victoria Maliandi ◽  
Ramon Alemany ◽  
Lluis Montoliu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Oncolytic Adenovirus ◽  
Anticancer Effects

Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
N Azoitei ◽  
GV Pusapati ◽  
A Kleger ◽  
C Brunner ◽  
F Genze ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Pancreatic Tumor

The Inhibition Effect of Caveolin-1 on PANC1 Human Pancreatic Tumor Growth In vitro and In vivo*

2012 ◽  
Vol 38 (12) ◽  
pp. 1121-1131
Author(s):  
Xiao-Hui WANG ◽  
Ya-Min ZHENG ◽  
Ye-Qing CUI ◽  
Shuang LIU ◽  
Hai-Chen SUN ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Caveolin 1 ◽  
Inhibition Effect

Blocking gp130-mediated IL-6 and Oncostatin M signaling inhibits pancreatic tumor growth in vivo

2021 ◽  
Author(s):  
I Pozios ◽  
E Günzler ◽  
N Hering ◽  
M Arndt ◽  
C Kamphues ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Oncostatin M

scholarly journals Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

2010 ◽  
Vol 78 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Indira Jutooru ◽  
Gayathri Chadalapaka ◽  
Maen Abdelrahim ◽  
Md Riyaz Basha ◽  
Ismael Samudio ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Specificity Protein ◽  
Protein Transcription

scholarly journals VEGF-specific Short Hairpin RNA–expressing Oncolytic Adenovirus Elicits Potent Inhibition of Angiogenesis and Tumor Growth

2007 ◽  
Vol 15 (2) ◽  
pp. 295-302 ◽  
Author(s):  
Ji Young Yoo ◽  
Joo-Hang Kim ◽  
Young-Guen Kwon ◽  
Eok-Cheon Kim ◽  
Nam Kyu Kim ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Short Hairpin Rna ◽  
Oncolytic Adenovirus ◽  
Hairpin Rna ◽  
Potent Inhibition ◽  
Inhibition Of Angiogenesis ◽  
Short Hairpin

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

2008 ◽  
Vol 68 (11) ◽  
pp. 4360-4368 ◽  
Author(s):  
Hongkui Jin ◽  
Renhui Yang ◽  
Zhong Zheng ◽  
Mally Romero ◽  
Jed Ross ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
The One

scholarly journals A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1412
Author(s):  
Chang Woo Han ◽  
Mi Suk Jeong ◽  
Sung Chul Ha ◽  
Se Bok Jang
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Direct Interaction ◽  
Activation Function ◽  
Stable Complex ◽  
Kras Mutations ◽  
Guanosine Diphosphate ◽  
Colon Cancer Cell Lines ◽  
Novel Drugs ◽  
High Binding Affinity

Kirsten-RAS (KRAS) has been the target of drugs because it is the most mutated gene in human cancers. Because of the low affinity of drugs for KRAS mutations, it was difficult to target these tumor genes directly. We found a direct interaction between KRAS G12V and tumor suppressor novel H-REV107 peptide with high binding affinity. We report the first crystal structure of an oncogenic mutant, KRAS G12V-H-REV107. This peptide was shown to interact with KRAS G12V in the guanosine diphosphate (GDP)-bound inactive state and to form a stable complex, blocking the activation function of KRAS. We showed that the peptide acted as an inhibitor of mutant KRAS targets by [α-32P] guanosine triphosphate (GTP) binding assay. The H-REV107 peptide inhibited pancreatic cancer and colon cancer cell lines in cell proliferation assay. Specially, the H-REV107 peptide can suppress pancreatic tumor growth by reduction of tumor volume and weight in xenotransplantation mouse models. Overall, the results presented herein will facilitate development of novel drugs for inhibition of KRAS mutations in cancer patients.

Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor

2020 ◽  
Vol 401 ◽  
pp. 115118
Author(s):  
Ye Yao ◽  
Qing-yu Yao ◽  
Jun-sheng Xue ◽  
Xiu-yun Tian ◽  
Qi-ming An ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Preclinical Models
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