scholarly journals Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 18991-19012 ◽  
Author(s):  
Tiantian Wang ◽  
Mei Wang ◽  
Shuang Fang ◽  
Qiang Wang ◽  
Rui Fang ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Patients ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

scholarly journals DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway

2017 ◽  
Vol 11 (9) ◽  
pp. 1208-1224 ◽  
Author(s):  
Jianxin Ye ◽  
Jie Xu ◽  
Yun Li ◽  
Qiang Huang ◽  
Jinsheng Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Gastric Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5

2019 ◽  
Vol 41 (4) ◽  
pp. 502-514 ◽  
Author(s):  
Hui Hu ◽  
Qin Zhang ◽  
Weiqun Chen ◽  
Tangwei Wu ◽  
Shuiyi Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Cancer Invasion ◽  
Janus Kinase ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
And Migration

AbstractPancreatic cancer is one of the most lethal digestive malignant tumors. We had previously found that microRNA-301a (miR-301a) is a oncogenic microRNA whose recognized conduce to nuclear factor-kappa B (NF-κB) activation in pancreatic cancer, yet the underlying mechanisms of miR-301a in promoting pancreatic cancer invasion and migration is obscure. In this work we found that high expression of miR-301a in human pancreatic cancer patients is related to poor survival. Overexpression of miR-301a enhances pancreatic cancer cell invasion, angiogenesis and migration, whereas inhibition of miR-301a suppresses pancreatic cancer cell invasion and reduces orthotopic pancreatic tumor growth and metastasis. Furthermore, suppressor of cytokine signaling 5 (SOCS5) is identified as a target gene of miR-301a. We found that miR-301a suppressed the expression of SOCS5 leads to janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) activation and is related to poor overall survival of pancreatic cancer patients. Taken together, our data show for the first time that the feedback loop between miR-301a and JAK/STAT3 pathway may play a significant role in pancreatic cancer invasion and metastasis. Targeting the loop may prove beneficial to prevent metastasis and provide a more effective therapeutic strategy for pancreatic cancer.

scholarly journals Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

2009 ◽  
Vol 3 (4) ◽  
pp. 351-354 ◽  
Author(s):  
Paul Timpson ◽  
Alan Serrels ◽  
Marta Canel ◽  
Margaret C. Frame ◽  
Valerie G. Brunton ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Real Time ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Real Time Imaging
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