scholarly journals MicroRNA-34a regulates liver regeneration and the development of liver cancer in rats by targeting Notch signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 13264-13276 ◽  
Author(s):  
Xiao-Ping Wang ◽  
Jian Zhou ◽  
Ming Han ◽  
Chuan-Bao Chen ◽  
Yi-Tao Zheng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Liver Regeneration ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

scholarly journals Overexpression of ERβ Participates in the Progression of Liver Cancer via Inhibiting the Notch Signaling Pathway [Retraction]

2020 ◽  
Vol Volume 13 ◽  
pp. 6849-6850
Author(s):  
Yiping Zhang ◽  
Benyi Yi ◽  
Xufeng Zhou ◽  
Yahua Wu ◽  
Lili Wang
Keyword(s):  
Liver Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

scholarly journals Overexpression Of ERβ Participates In The Progression Of Liver Cancer Via Inhibiting The Notch Signaling Pathway

2019 ◽  
Vol Volume 12 ◽  
pp. 8715-8724 ◽  
Author(s):  
Yiping Zhang ◽  
Benyi Yi ◽  
Xufeng Zhou ◽  
Yahua Wu ◽  
Lili Wang
Keyword(s):  
Liver Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

Notch signaling pathway regulates cell cycle in proliferating hepatocytes involved in liver regeneration

2018 ◽  
Vol 33 (8) ◽  
pp. 1538-1547 ◽  
Author(s):  
Fen Zhang ◽  
Jinglong Zhang ◽  
Xiao Li ◽  
Bowei Li ◽  
Kaishan Tao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Liver Regeneration ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

Comparative Analysis of Regulatory Role of Notch Signaling Pathway in 8 Types Liver Cell During Liver Regeneration

2018 ◽  
Vol 57 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Xianguang Yang ◽  
Chuncui He ◽  
Lin Zhu ◽  
Weiming Zhao ◽  
Shuaihong Li ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Liver Regeneration ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Liver Cell ◽  
Notch Signaling Pathway ◽  
Regulatory Role

Regulation of EMT by Notch Signaling Pathway in Tumor Progression

2013 ◽  
Vol 13 (9) ◽  
pp. 957-962 ◽  
Author(s):  
Yumei Li ◽  
Jia Ma ◽  
Xiujuan Qian ◽  
Qiong Wu ◽  
Jun Xia ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway.

2020 ◽  
Vol 20 ◽  
Author(s):  
Imran Khan ◽  
Sadaf Mahfooz ◽  
Mohd Saeed ◽  
Irfan Ahmad ◽  
Irfan A. Ansari
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Mtt Assay ◽  
Annexin V ◽  
Notch Signaling Pathway ◽  
Phase Cell ◽  
Ros Generation ◽  
Notch 1

Background: Recently Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. However, the efficacy of previously known Notch inhibitors in colon cancer is still unclear. The purpose of this study was to investigate the effect of andrographolide on aberrantly activated Notch signaling in SW-480 cells in vitro. Methods: The cytostatic potential of andrographolide on SW-480 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay, morphology assessment and colony formation assay. The apoptotic activity was evaluated by FITC Annexin V assay, 4′,6-diamidino-2-phenylindole (DAPI), Hoechst, Rhodamine 123 and Mito Tracker CMXRos staining. Scratch assay for migratory potential assessment. 7’-Dichlorodihydrofluorescein Diacetate (DCFH-DA) staining was used to evaluate the Reactive Oxygen Species (ROS) generation. Relative mRNA expression of Bax, Bcl2, NOTCH 1 and JAGGED 1 was estimated by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Cell cycle phase distribution was evaluated Annexin V-FITC/PI staining. Results: MTT assay demonstrated dose and time dependent cytoxicity of andrographolide on SW-480 cells. It also inhibited the migratory and colony forming potential of SW-480 cells. Furthermore, andrographolide also showed disruption of mitochondrial membrane potential and induced apoptosis through nuclear condensation. Flow cytometric evaluation showed andrographolide enhanced early and late apoptotic cells and induced upregulation of proapoptotic (Bax and Bad) and downregulation of antiapoptotic Bcl2 in treated SW-480 cells. Andrographolide augmented intracellular ROS generation and induced G0/G1 phase cell cycle arrest in colon cancer SW480 cells. Furthermore, andrographolide repressed the Notch signaling by decreasing the expression of NOTCH 1 and JAGGED 1. Conclusion: Our findings suggested that andrographolide constraint the growth of SW-480 cells through the inhibition of Notch signaling pathway.

Notch signaling pathway in infectious diseases: role in the regulation of immune response

2021 ◽  
Vol 70 (3) ◽  
pp. 261-274
Author(s):  
Ricardo Cardoso Castro ◽  
Relber Aguiar Gonçales ◽  
Fabiana Albani Zambuzi ◽  
Fabiani Gai Frantz
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway
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