scholarly journals Genome-wide copy number aberrations and HER2 and FGFR1 alterations in primary breast cancer by molecular inversion probe microarray

Oncotarget ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 10845-10857 ◽  
Author(s):  
Hui Chen ◽  
Rajesh R. Singh ◽  
Xinyan Lu ◽  
Lei Huo ◽  
Hui Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Copy Number ◽  
Copy Number Aberrations ◽  
Genome Wide ◽  
Molecular Inversion Probe

Genome-wide copy number analysis in primary breast cancer

2012 ◽  
Vol 16 (sup1) ◽  
pp. S31-S35 ◽  
Author(s):  
Takayuki Ueno ◽  
Mitsuru Emi ◽  
Hidenori Sato ◽  
Noriko Ito ◽  
Mariko Muta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Copy Number ◽  
Copy Number Analysis ◽  
Genome Wide

Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis

2014 ◽  
Vol 53 (4) ◽  
pp. 324-338 ◽  
Author(s):  
Adam Frankel ◽  
Nicola Armour ◽  
Derek Nancarrow ◽  
Lutz Krause ◽  
Nicholas Hayward ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Copy Number ◽  
Genome Wide Analysis ◽  
Copy Number Aberrations ◽  
Genome Wide

Abstract 4720: Genome-wide copy number variation and breast cancer risk: Preliminary report

2010 ◽  
Author(s):  
Kyoung-Mu Lee ◽  
Miey Park ◽  
Sang-Hoon Moon ◽  
Hyung-Chol Kim ◽  
Ji-Young Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Copy Number Variation ◽  
Copy Number ◽  
Preliminary Report ◽  
Genome Wide ◽  
Number Variation

scholarly journals Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Hiroko K Solvang ◽  
Ole Christian Lingjærde ◽  
Arnoldo Frigessi ◽  
Anne-Lise Børresen-Dale ◽  
Vessela N Kristensen
Keyword(s):  
Breast Cancer ◽  
Mrna Expression ◽  
Copy Number ◽  
Molecular Pathways ◽  
Copy Number Aberrations ◽  
Non Linear

scholarly journals A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility

2016 ◽  
Vol 149 (3) ◽  
pp. 156-164 ◽  
Author(s):  
Yadav Sapkota ◽  
Ashok Narasimhan ◽  
Mahalakshmi Kumaran ◽  
Badan S. Sehrawat ◽  
Sambasivarao Damaraju
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Copy Number ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Frequency Effect ◽  
Potential Candidate ◽  
Disease Etiology ◽  
Genome Wide ◽  
A Genome

Breast cancer (BC) predisposition in populations arises from both genetic and nongenetic risk factors. Structural variations such as copy number variations (CNVs) are heritable determinants for disease susceptibility. The primary objectives of this study are (1) to identify CNVs associated with sporadic BC using a genome-wide association study (GWAS) design; (2) to utilize 2 distinct CNV calling algorithms to identify concordant CNVs as a strategy to reduce false positive associations in the hypothesis-generating GWAS discovery phase, and (3) to identify potential candidate CNVs for follow-up replication studies. We used Affymetrix SNP Array 6.0 data profiled on Caucasian subjects (422 cases/348 controls) to call CNVs using algorithms implemented in Nexus Copy Number and Partek Genomics Suite software. Nexus algorithm identified CNVs associated with BC (731 autosomal CNVs with >5% frequency in the total sample and Q < 0.05). Thirteen CNVs were identified when Partek algorithm-called CNVs were overlapped with Nexus-identified CNVs; these CNVs showed concordances for frequency, effect size, and direction. Coding genes present within BC-associated CNVs were known to play a role in disease etiology and prognosis. Long noncoding RNAs identified within CNVs showed tissue-specific expression, indicating potential functional relevance of the findings. The identified candidate CNVs warrant independent replication.

Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer

2016 ◽  
Vol 15 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Rosa Murria Estal ◽  
Sarai Palanca Suela ◽  
Inmaculada de Juan Jiménez ◽  
Cristina Alenda Gonzalez ◽  
Cecilia Egoavil Rojas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Sporadic Breast Cancer ◽  
Copy Number Aberrations ◽  
Relationship Of

scholarly journals Germline DNA Copy Number Aberrations Identified as Potential Prognostic Factors for Breast Cancer Recurrence

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53850 ◽  
Author(s):  
Yadav Sapkota ◽  
Sunita Ghosh ◽  
Raymond Lai ◽  
Bradley P. Coe ◽  
Carol E. Cass ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Copy Number ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Dna Copy Number ◽  
Copy Number Aberrations ◽  
Dna Copy Number Aberrations
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