scholarly journals Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-β-induced expression of VEGFA

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6169-6178 ◽  
Author(s):  
Swaathi Jayaraman ◽  
Michele Doucet ◽  
Scott L. Kominsky
Keyword(s):  
Tumor Growth ◽  
Breast Tumor ◽  
Down Regulation ◽  
Induced Expression ◽  
Vessel Formation ◽  
Growth Vessel

scholarly journals Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

2019 ◽  
Vol 223 ◽  
pp. 115034 ◽  
Author(s):  
Catarina Oliveira ◽  
Sara Granja ◽  
Nuno M Neves ◽  
Rui L Reis ◽  
Fátima Baltazar ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tumor Growth ◽  
Breast Tumor ◽  
Fucus Vesiculosus ◽  
Blood Vessel Formation ◽  
Vessel Formation

Hormonal Factors and Breast Tumor Proliferation: Do Factors that Affect Cancer Risk also Affect Tumor Growth?

2004 ◽  
Vol 85 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Nina Oestreicher ◽  
Emily White ◽  
Kathleen E. Malone ◽  
Peggy L. Porter
Keyword(s):  
Cancer Risk ◽  
Tumor Growth ◽  
Breast Tumor ◽  
Tumor Proliferation ◽  
Hormonal Factors

scholarly journals Investigating New Therapeutic Strategies Targeting Hyperinsulinemia's Mitogenic Effects in a Female Mouse Breast Cancer Model

Endocrinology ◽  
2013 ◽  
Vol 154 (5) ◽  
pp. 1701-1710 ◽  
Author(s):  
Ran Rostoker ◽  
Keren Bitton-Worms ◽  
Avishay Caspi ◽  
Zila Shen-Orr ◽  
Derek LeRoith
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Breast Tumor ◽  
Experimental Studies ◽  
Tumor Development ◽  
Treated Group ◽  
Tumor Growth Rate ◽  
Breast Cancer Patients ◽  
Mitogenic Effect

Abstract Epidemiological and experimental studies have identified hyperinsulinemia as an important risk factor for breast cancer induction and for the poor prognosis in breast cancer patients with obesity and type 2 diabetes. Recently it was demonstrated that both the insulin receptor (IR) and the IGF-IR mediate hyperinsulinemia's mitogenic effect in several breast cancer models. Although IGF-IR has been intensively investigated, and anti-IGF-IR therapies are now in advanced clinical trials, the role of the IR in mediating hyperinsulinemia's mitogenic effect remains to be clarified. Here we aimed to explore the potential of IR inhibition compared to dual IR/IGF-IR blockade on breast tumor growth. To initiate breast tumors, we inoculated the mammary carcinoma Mvt-1 cell line into the inguinal mammary fat pad of the hyperinsulinemic MKR female mice, and to study the role of IR, we treated the mice bearing tumors with the recently reported high-affinity IR antagonist-S961, in addition to the well-documented IGF-IR inhibitor picropodophyllin (PPP). Although reducing IR activation, with resultant severe hyperglycemia and hyperinsulinemia, S961-treated mice had significantly larger tumors compared to the vehicle-treated group. This effect maybe secondary to the severe hyperinsulinemia mediated via the IGF-1 receptor. In contrast, PPP by partially inhibiting both IR and IGF-IR activity reduced tumor growth rate with only mild metabolic consequences. We conclude that targeting (even partially) both IR and IGF-IRs impairs hyperinsulinemia's effects in breast tumor development while simultaneously sparing the metabolic abnormalities observed when targeting IR alone with virtual complete inhibition.

scholarly journals Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth

iScience ◽  
2021 ◽  
Vol 24 (9) ◽  
pp. 103012
Author(s):  
Alastair M. McKee ◽  
Benjamin M. Kirkup ◽  
Matthew Madgwick ◽  
Wesley J. Fowler ◽  
Christopher A. Price ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Tumor Growth ◽  
Breast Tumor

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice

2014 ◽  
Vol 28 (6) ◽  
pp. 2655-2666 ◽  
Author(s):  
Matthew G. K. Benesch ◽  
Xiaoyun Tang ◽  
Tatsuo Maeda ◽  
Akira Ohhata ◽  
Yuan Y. Zhao ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Breast Tumor
Sign in / Sign up

Export Citation Format

Share Document