scholarly journals Leptin-Notch signaling axis is involved in pancreatic cancer progression

Oncotarget ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 7740-7752 ◽  
Author(s):  
Adriana Harbuzariu ◽  
Antonio Rampoldi ◽  
Danielle S Daley-Brown ◽  
Pierre Candelaria ◽  
Tia L Harmon ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Signaling Axis

scholarly journals Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

2011 ◽  
Vol 121 (12) ◽  
pp. 4685-4699 ◽  
Author(s):  
Eleni Maniati ◽  
Maud Bossard ◽  
Natalie Cook ◽  
Juliana B. Candido ◽  
Nia Emami-Shahri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Pparγ Expression

Inhibition of Notch signaling attenuates pancreatic cancer progression

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
RR Plentz ◽  
S Sankaran ◽  
BZ Stanger ◽  
PK Majumder ◽  
N Bardeesy
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Cancer Progression

TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR‐glycolysis signaling axis

2019 ◽  
Vol 121 (2) ◽  
pp. 1986-1997 ◽  
Author(s):  
Rongkun Li ◽  
Li Weng ◽  
Bingyan Liu ◽  
Lili Zhu ◽  
Xiaoxin Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Signaling Axis

scholarly journals The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer

Medicines ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. 68 ◽  
Author(s):  
Adriana Harbuzariu ◽  
Gabriela Oprea-Ilies ◽  
Ruben Gonzalez-Perez
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Treatment Success ◽  
Notch Signaling Pathway ◽  
Cancer Development ◽  
Cancer Cell Proliferation ◽  
The Novel ◽  
Cancer Types

There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nuclear partner of activated Notch) independent of Notch signaling pathway seem to affect differently cancer progression. Recent data show that in PC and other cancer types the adipokine leptin can modulate Notch/RBP-Jk signaling, thereby, linking the pandemic obesity with cancer and chemoresistance. The potential pivotal role of leptin on PC, and its connection with Notch signaling and chemoresistance are still not completely understood. In this review, we will describe the most important aspects of Notch-RBP-Jk signaling in PC. Further, we will discuss on studies related to RBP-Jk-independent Notch and Notch-independent RPB-Jk signaling. We will also discuss on the novel crosstalk between leptin and Notch in PC and its implications in chemoresistance. The effects of leptin-Notch/RBP-Jk signaling on cancer cell proliferation, apoptosis, and drug resistance require more investigation. Data from these investigations could help to open unexplored ways to improve PC treatment success that has shown little progress for many years.

Stress-induced phosphoprotein 1 promotes pancreatic cancer progression through activation of the FAK/AKT/MMP signaling axis

2019 ◽  
Vol 215 (11) ◽  
pp. 152564 ◽  
Author(s):  
Yuanming Jing ◽  
Wenqing Liang ◽  
Jian Liu ◽  
Lin Zhang ◽  
Jianguo Wei ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Signaling Axis

scholarly journals PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

Neoplasia ◽  
2021 ◽  
Vol 23 (9) ◽  
pp. 912-928
Author(s):  
Yihui Ma ◽  
Peiyi Xia ◽  
Zhengyang Wang ◽  
Jingjing Xu ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Immune Escape
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