scholarly journals Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1944-1952 ◽  
Author(s):  
Zhaoli Chen ◽  
Xuejiao Shi ◽  
Lanwei Guo ◽  
Yuan Li ◽  
Mei Luo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Progression ◽  
Meta Analysis ◽  
Poor Survival

scholarly journals NIMA-related kinase 2 overexpression is associated with poor survival in cancer patients: a systematic review and meta-analysis

2019 ◽  
Vol Volume 11 ◽  
pp. 455-465 ◽  
Author(s):  
Yang Yao ◽  
Jie Su ◽  
Lei Zhao ◽  
Na Luo ◽  
Lihui Long ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Poor Survival

PIK3CA Mutations and Their Impact on Survival Outcomes of Patients with Cervical Cancer: A Systematic Review

2020 ◽  
Vol 64 (6) ◽  
pp. 547-555
Author(s):  
Vasilios Pergialiotis ◽  
Christina Nikolaou ◽  
Dimitrios Haidopoulos ◽  
Maximos Frountzas ◽  
Nikolaos Thomakos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Cancer Progression ◽  
Meta Analysis ◽  
Current Evidence ◽  
Survival Outcomes ◽  
Cochrane Central Register ◽  
Wild Type ◽  
Pik3ca Mutations ◽  
The Impact

<b><i>Introduction:</i></b> Several studies have implicated the PIK3/AKT pathway in the pathophysiology of cancer progression as its activation seems to be aberrant in several forms of cancer. The purpose of the present systematic review is to evaluate the impact of PIK3CA mutations on survival outcomes of patients with cervical cancer. <b><i>Methods:</i></b> We used the Medline (1966–2020), Scopus (2004–2020), ClinicalTrials.gov (2008–2020), EMBASE (1980–2020), Cochrane Central Register of Controlled Trials (CENTRAL) (1999–2020), and Google Scholar (2004–2020) databases in our primary search along with the reference lists of electronically retrieved full-text papers. Statistical meta-analysis was performed with the RevMan 5.3 software. <b><i>Results:</i></b> Overall, 12 articles were included in the present study that comprised 2,196 women with cervical cancer. Of those, 3 studies did not report significant differences in survival outcomes among patients with mutated versus wild-type PIK3CA tumors, 5 studies reported decreased survival outcomes, and 3 studies revealed increased survival rates. The meta-analysis revealed that patients with the mutated PIK3CA genotypes had worse overall survival compared to patients with wild-type PIK3CA (HR 2.31; 95% CI: 1.51, 3.55; 95% PI: 0.54, 9.96; data from 3 studies) and the same was observed in the case of DFS rates (HR 1.82; 95% CI: 1.47, 2.25; 95% PI: 1.29, 2.56; data from 4 studies). <b><i>Conclusion:</i></b> Current evidence concerning the impact of PIK3CA mutations on survival outcomes of patients with cervical cancer is inconclusive, although the majority of included studies support a potential negative effect, primarily among those with squamous cell carcinoma tumors.

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

Oral Diseases ◽  
2019 ◽  
Vol 26 (4) ◽  
pp. 733-744 ◽  
Author(s):  
Diana Graizel ◽  
Ayelet Zlotogorski‐Hurvitz ◽  
Igor Tsesis ◽  
Eyal Rosen ◽  
Ron Kedem ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cancer ◽  
Meta Analysis ◽  
Cancer Associated Fibroblasts ◽  
Poor Survival

scholarly journals MCT4 has a potential to be used as a prognostic biomarker - a systematic review and meta-analysis

2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Arslaan Javaeed ◽  
Sanniya Khan Ghauri
Keyword(s):  
Systematic Review ◽  
Cancer Progression ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Prognostic Indicators ◽  
Future Research ◽  
Tissue Samples ◽  
Hazard Ratios

The role of several metabolic changes, such as hypoxia and acidosis, in the tumour environment has caught the attention of researchers in cancer progression and invasion. Lactate transport is one of the acidosis-enhancing processes that are mediated via monocarboxylate transporters (MCTs). We conducted a systematic review and meta-analysis to investigate the expression of two cancer-relevant MCTs (MCT1 and MCT4) and their potential prognostic significance in patients with metastasis of different types of cancer. Studies were included if they reported the number of metastatic tissue samples expressing either low or high levels of MCT1 and/or MCT4 or those revealing the hazard ratios (HRs) of the overall survival (OS) or disease-free survival (DFS) as prognostic indicators. During the period between 2010 and 2018, a total of 20 articles including 3831 patients (56.3% males) were identified. There was a significant association between MCT4 expression (high versus low) and lymph node metastasis [odds ratio (OR)=1.87, 95% confidence interval (CI)=1.10-3.17, P=0.02] and distant metastasis (OR=2.18, 95%CI=1.65-2.86, P<0.001) and the correlation remained significant for colorectal and hepatic cancer in subgroup analysis. For survival analysis, patients with shorter OS periods exhibited a higher MCT4 expression [hazard ratio (HR)=1.78, 95%CI=1.49-2.13, P<0.001], while DFS was shorter in patients with high MCT1 (HR=1.48, 95%CI=1.04-2.10, P=0.03) and MCT4 expression (HR=1.70, 95%CI=1.19-2.42, P=0.003) when compared to their counterparts with low expression levels. Future research studies should consider the pharmacologic inhibition of MCT4 to effectively inhibit cancer progression to metastasis.

scholarly journals Elevated Expression of miR-210 Predicts Poor Survival of Cancer Patients: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89223 ◽  
Author(s):  
Jian Wang ◽  
Jiqing Zhao ◽  
Mengjing Shi ◽  
Yu Ding ◽  
Huiqin Sun ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Poor Survival ◽  
Elevated Expression

An exploration of the role of exercise in modulating breast cancer progression in vitro (a systematic review and meta-analysis)

2020 ◽  
Author(s):  
Marie-Juliet Brown ◽  
Mhairi A. Morris ◽  
Elizabeth C. Akam
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Meta Analysis ◽  
Future Research ◽  
Exercise Interventions

Background: Breast cancer is the most prevalent cancer in women worldwide. In the UK, approximately 5% of all breast cancers are already metastatic at the time of diagnosis. An abundance of literature shows exercise can have beneficial effects on the outcome and prognosis of breast cancer patients, yet the molecular mechanisms remain poorly understood. There are several in vitro models that aim to recapitulate the response of breast cancer to exercise in vivo: this systematic review and meta-analysis summarises the existing literature. Methods: The following search terms were used to conduct a systematic literature search using a collection of databases (last search performed May 2020): 'in vitro' and 'exercise' and 'breast cancer'. Only studies that investigated the effects of exercise on breast cancer in vitro were included. Standardised mean differences (SMD) were calculated to determine pooled effect sizes. Results: This meta-analysis has successfully demonstrated that various identified exercise interventions on breast cancer cells in vitro significantly reduced breast cancer cell viability, proliferation, and tumourigenic potential (SMD: -1.76, p = 0.004, SMD: -2.85, p = 0.003 and SMD: -3.15, p = 0.0008, respectively). A clear direction of effect was found with exercise on breast cancer cell migration in vitro, however this effect was not significant (SMD: -0.62, p = 0.317). Conclusion: To our knowledge, this is the first meta-analysis and systematic review investigating and summarising literature on exercise and breast cancer in vitro, highlighting models used and priority areas for future research focus.

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