scholarly journals Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1495-1507 ◽  
Author(s):  
Danielle M. Karyadi ◽  
Milan S. Geybels ◽  
Eric Karlins ◽  
Brennan Decker ◽  
Laura McIntosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Exome Sequencing ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Case Control Studies ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility ◽  
Whole Exome ◽  
Independent Case

Prostate cancer susceptibility genes: lessons learned and challenges posed.

2003 ◽  
pp. 225-259 ◽  
Author(s):  
J Simard ◽  
M Dumont ◽  
D Labuda ◽  
D Sinnett ◽  
C Meloche ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Screening Methods ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility ◽  
Common Genetic Variants

In most developed countries, prostate cancer is the most frequently diagnosed malignancy in men. The extent to which the marked racial/ethnic difference in its incidence rate is attributable to screening methods, environmental, hormonal and/or genetic factors remains unknown. A positive family history is among the strongest epidemiological risk factors for prostate cancer. It is now well recognized that the role of candidate genetic markers to this multifactorial malignancy is more difficult to identify than the identification of other cancer susceptibility genes. Indeed, despite the localization of several susceptibility loci, there has been limited success in identifying high-risk susceptibility genes analogous to BRCA1 or BRCA2 for breast and ovarian cancer. Nonetheless, three strong candidate susceptibility genes have been described, namely ELAC2 (chromosome 17p11/HPC2 region), 2'-5'-oligoadenylate-dependent ribonuclease L (RNASEL), a gene in the HPC1 region, and Macrophage Scavenger Receptor 1 (MSR1), a gene within a region of linkage on chromosome 8p. Additional studies using larger cohorts are needed to fully evaluate the role of these susceptibility genes in prostate cancer risk. It is also of interest to mention that a significant percentage of men with early-onset prostate cancer harbor germline mutation in the BRCA2 gene thus confirming its role as a high-risk prostate cancer susceptibility gene. Although initial segregation analyses supported the hypothesis that a number of rare highly penetrant loci contribute to the Mendelian inheritance of prostate cancer, current experimental evidence better supports the hypothesis that some of the familial risks may be due to inheritance of multiple moderate-risk genetic variants. In this regard, it is not surprising that analyses of genes encoding key proteins involved in androgen biosynthesis and action led to the observation of a significant association between a susceptibility to prostate cancer and common genetic variants in some of those genes.

scholarly journals Confirmation of Prostate Cancer Susceptibility Genes Using High-Risk Families

1999 ◽  
Vol 1999 (26) ◽  
pp. 81-87 ◽  
Author(s):  
G. P. Jarvik ◽  
J. L. Stanford ◽  
E. L. Goode ◽  
R. McIndoe ◽  
S. Kolb ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility ◽  
High Risk Families

Replication linkage study for prostate cancer susceptibility genes

The Prostate ◽  
2000 ◽  
Vol 45 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Brian K. Suarez ◽  
Jennifer Lin ◽  
John S. Witte ◽  
David V. Conti ◽  
Martin I. Resnick ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Linkage Study ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility

Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families

The Prostate ◽  
2003 ◽  
Vol 57 (4) ◽  
pp. 320-325 ◽  
Author(s):  
Jianfeng Xu ◽  
Elizabeth M. Gillanders ◽  
Sarah D. Isaacs ◽  
Bao-li Chang ◽  
Kathy E. Wiley ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Hereditary Prostate Cancer ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility ◽  
Genome Wide ◽  
Genome Wide Scan

scholarly journals Prostate cancer susceptibility genes on 8p21–23 in a Dutch population

2013 ◽  
Vol 16 (3) ◽  
pp. 248-253 ◽  
Author(s):  
M P Zeegers ◽  
D Nekeman ◽  
H S Khan ◽  
B A C van Dijk ◽  
R A Goldbohm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Dutch Population ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility

scholarly journals A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes

PLoS Genetics ◽  
2014 ◽  
Vol 10 (11) ◽  
pp. e1004809 ◽  
Author(s):  
Kendra A. Williams ◽  
Minnkyong Lee ◽  
Ying Hu ◽  
Jonathan Andreas ◽  
Shashank J. Patel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Systems Genetics ◽  
Aggressive Prostate Cancer ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility
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