scholarly journals TIMP-2 SNPs rs7342880 and rs4789936 are linked to risk of knee osteoarthritis in the Chinese Han Population

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1166-1176 ◽  
Author(s):  
Pengcheng Xu ◽  
Wen Guo ◽  
Tianbo Jin ◽  
Jihong Wang ◽  
Dongsheng Fan ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Gang Sun ◽  
Cheng-Lei Ba ◽  
Ren Gao ◽  
Wenqing Liu ◽  
Qiang Ji
Keyword(s):  
Knee Osteoarthritis ◽  
Disease Severity ◽  
Gene Polymorphisms ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Expression Levels ◽  
Matrix Metalloproteinase 13 ◽  
Synovial Fluids

Abstract Objective: To identify the association between the interleukin (IL) 6 (IL-6) rs1800795 (-174 G>C), IL-8 rs4073 (-251T>A), and matrix metalloproteinase-13 (MMP-13) rs2252070 (-77G>A) gene polymorphisms and knee osteoarthritis (KOA) susceptibility in the Chinese Han population. Methods: Genomic DNA was extracted from a total of 400 KOA patients and 400 healthy subjects. Sanger sequencing was performed to determine the genotypes of the IL-6 rs1800795 (-174 G/C), IL-8 rs4073 (-251A/T), and MMP-13 rs2252070 (-77A/G) loci. The mRNA expression levels of IL-6, IL-8, and MMP-13 in osteoblasts and the protein expression levels of IL-6, IL-8, and MMP-13 in the synovial fluids of KOA patients were analyzed. Results: The recessive model of IL-6 rs1800795 locus was found to be associated with KOA risk (adjusted odds ratio (OR) = 1.657, 95% confidence interval (CI) = 1.396–1.866, P<0.001). The IL-8 rs4073 locus dominant and recessive model showed no significant association with KOA risk (P>0.05). The dominant and recessive models of the MMP-13 rs2252070 locus showed higher risk for developing KOA (dominant model: adjusted OR = 1.271, 95%CI = 1.095–1.480, P=0.001; recessive model: adjusted OR = 1.361 95%CI = 1.151–1.569, P<0.001). The G>C mutation in IL-6 rs1800795 and the G>A mutation in MMP-13 rs2252070 were associated with significantly higher KOA disease severity. The G>C mutation in the IL-6 rs1800795 locus was associated with up-regulation of IL-6 expression. The G>A mutation in the MMP-13 rs2252070 locus was associated with up-regulation of MMP-13 expression. Conclusion: The IL-8 rs4073 (-251T>A) mutation was not associated with KOA susceptibility. The IL-6 rs1800795 (-174 G>C) and MMP-13 rs2252070 (-77G>A) mutations were associated with KOA susceptibility, increased disease severity, and up-regulation of IL-6 and MMP-13 expression levels.

scholarly journals Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis

2021 ◽  
Vol Volume 15 ◽  
pp. 5075-5086
Author(s):  
Ruofei Chen ◽  
Yaqin Zhang ◽  
Honggang Xu ◽  
Huaqing Hu ◽  
Mingwei Chen ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Knee Osteoarthritis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association between transforming growth factor-beta 1 gene single nucleotide polymorphisms and knee osteoarthritis susceptibility in a Chinese Han population

2017 ◽  
Vol 45 (5) ◽  
pp. 1495-1504 ◽  
Author(s):  
Ning Lu ◽  
Jianwei Lu ◽  
Chenhe Zhou ◽  
FuHua Zhong
Keyword(s):  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Transforming Growth Factor ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Knee Oa ◽  
Increased Risk ◽  
Gender And Age ◽  
Tgf Β1

Objective To investigate associations between single polymorphisms (SNPs) rs1800469 and rs1982073 in the transforming growth factor-β1 gene ( TGF-β1) and knee osteoarthritis (OA) susceptibility in a Chinese Han population. Methods TGF-β1 rs1800469 and rs1982073 were genotyped in patients with knee OA and age- and sex-matched OA-free controls from a Chinese Han population. The association was further analyzed according to gender and age. Results A total of 765 patients with knee OA and 780 controls were included. CT and CT + CC genotypes of rs1982073, and variant C, were associated with a significantly increased risk of knee OA. Stratification analysis showed that the association between the OA risk and rs1982073 CT heterozygotes compared with TT homozygotes was stronger in females and those aged >65 years. In contrast, CT, TT, and CT + TT genotypes of rs1800469 were not significantly associated with the risk of knee OA, even after further stratification analysis for gender and age. Conclusions The TGF-β1 rs1982073 T to C change and the variant C genotype may contribute to knee OA risk in the Chinese Han population.

Combined effect of cytokine gene polymorphisms on end-stage knee osteoarthritis from Chinese Han population

2011 ◽  
Vol 32 (11) ◽  
pp. 3625-3629 ◽  
Author(s):  
Chengyu Lv ◽  
Xiaoyan Xu ◽  
Jinqing Wang ◽  
Zhongyi Zhang ◽  
Dianliang Zhang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Gene Polymorphisms ◽  
Combined Effect ◽  
Chinese Han Population ◽  
Cytokine Gene ◽  
Chinese Han ◽  
Han Population ◽  
Cytokine Gene Polymorphisms ◽  
End Stage
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