scholarly journals Genetic variants in the acylphosphatase 2 gene and the risk of breast cancer in a Han Chinese population

Oncotarget ◽  
2016 ◽  
Vol 7 (52) ◽  
pp. 86704-86712 ◽  
Author(s):  
Fuli Zhang ◽  
Yan Zhang ◽  
Zhiping Deng ◽  
Pengcheng Xu ◽  
Xiyang Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variants ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 85483-85491 ◽  
Author(s):  
Xu Li ◽  
Wenjing Zou ◽  
Ming Liu ◽  
Wei Cao ◽  
Yonghong Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variants ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population

Medicine ◽  
2016 ◽  
Vol 95 (23) ◽  
pp. e3841 ◽  
Author(s):  
Xiaomu Kong ◽  
Xiaoyan Xing ◽  
Jing Hong ◽  
Xuelian Zhang ◽  
Wenying Yang
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Genetic Variants in Meiotic Program Initiation Pathway Genes Are Associated with Spermatogenic Impairment in a Han Chinese Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53443 ◽  
Author(s):  
Chuncheng Lu ◽  
Miaofei Xu ◽  
Ying Wang ◽  
Yufeng Qin ◽  
Guizhen Du ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

Association between Ocular Axial Length-Related Genes and High Myopia in a Han Chinese Population

2015 ◽  
Vol 235 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Ya-Ting Li ◽  
Ming-Kun Xie ◽  
Jin Wu
Keyword(s):  
Axial Length ◽  
Genetic Variants ◽  
Chinese Population ◽  
High Myopia ◽  
Genome Wide Association Study ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Han Chinese Population ◽  
Functional Roles ◽  
Genome Wide

Aims: A previous genome-wide association study of high myopia identified five genome-wide loci for ocular axial length (C3orf26, ZC3H11B, RSPO1, GJD2, and ZNRF3). The aim of our study was to investigate the association between high myopia and genetic variants in the five loci in Han Chinese subjects. Methods: Five single nucleotide polymorphisms were genotyped in 296 unrelated high-myopia subjects and 300 matched emmetropic controls by the SNaPshot method. The distribution of genotypes in the cases and controls was compared in codominant, dominant, and recessive genetic models by using SNPStats online software. Results: Significant associations between rs994767 near ZC3H11B (p = 0.001), rs4074961 in RSPO1 (p < 0.001), and rs11073058 in GJD2 (p = 0.029) and high myopia were observed. Odds ratios (95% confidence intervals) were 1.532 (1.200-1.955), 1.603 (1.267-2.029), and 1.290 (1.027-1.621) for the rs994767 T allele, rs4074961 T allele, and rs11073058 T allele, respectively. But rs9811920 in C3orf26 and rs12321 in ZNRF3 were not associated with high myopia. Conclusion: Our findings suggested that genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population. Functional roles of ZC3H11B, RSPO1, and GJD2 in the pathology of high myopia need to be further investigated.

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