scholarly journals Enhanced circulating transforming growth factor beta 1 is causally associated with an increased risk of hepatocellular carcinoma: a mendelian randomization meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 84695-84704 ◽  
Author(s):  
Wei-Qun LU ◽  
Ji-Liang QIU ◽  
Zhi-Liang HUANG ◽  
Hai-Ying LIU
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Increased Risk ◽  
Growth Factor Beta

scholarly journals The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 20 (15) ◽  
pp. 3831
Author(s):  
Ilaria Girolami ◽  
Nicola Veronese ◽  
Lee Smith ◽  
Maria G. Caruso ◽  
Rosa Reddavide ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Meta Analysis ◽  
Gastrointestinal Cancers ◽  
Phosphorylated Form ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Growth Factor Beta ◽  
Tumor Types ◽  
Activation Status

Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which was meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05–2.37, p = 0.029, I2 = 84%), also after having adjusted for potential confounders (RR, 1.65; 95% CI, 1.24–2.18; p < 0.001; I2 = 4%). This finding highlights the importance of the TGF-β signaling in this type of cancer. In this line, further studies are needed to explore more in depth this important molecular pathway, focusing also on potential therapeutic strategies based on its effectors or molecular targets.

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