scholarly journals Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 81527-81540 ◽  
Author(s):  
Xiao-Lin Wang ◽  
Wei-Ping Shi ◽  
Hong-Can Shi ◽  
Shi-Chun Lu ◽  
Kang Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Therapeutic Target ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell

Plant-Derived Protease Inhibitors LC-pi (Lavatera cashmeriana) Inhibit Human Lung Cancer Cell Proliferation In Vitro

2014 ◽  
Vol 67 (1) ◽  
pp. 156-166 ◽  
Author(s):  
Syed Rakashanda ◽  
Asif Khurshid Qazi ◽  
Rabiya Majeed ◽  
Syed Mubashir Andrabi ◽  
Abid Hamid ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Protease Inhibitors ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Proliferation In Vitro

scholarly journals Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Cancers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 46 ◽  
Author(s):  
Nigel Kurgan ◽  
Evelyn Tsakiridis ◽  
Rozalia Kouvelioti ◽  
Jessy Moore ◽  
Panagiota Klentrou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Post Exercise ◽  
Human Lung Cancer Cell ◽  
P70 S6k

scholarly journals Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

2016 ◽  
Vol 12 (3) ◽  
pp. 2189-2193 ◽  
Author(s):  
Yang Yang ◽  
Aimin Zang ◽  
Youchao Jia ◽  
Yanhong Shang ◽  
Zhuoqi Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Inhibition of human lung cancer cell proliferation and survival by wine

2014 ◽  
Vol 14 (1) ◽  
pp. 6 ◽  
Author(s):  
Carly C Barron ◽  
Jessy Moore ◽  
Theodoros Tsakiridis ◽  
Gary Pickering ◽  
Evangelia Tsiani
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

Reciprocal activation of α5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation

2017 ◽  
Vol 44 (7) ◽  
pp. 355-362 ◽  
Author(s):  
Yao Zhang ◽  
Yanfei Jia ◽  
Ping Li ◽  
Huanjie li ◽  
Dongjie Xiao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Mingxia Yan ◽  
Lei Sun ◽  
Jing Li ◽  
Huajian Yu ◽  
Hechun Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Small Cell Lung

Abstract Background KH-type splicing regulatory protein (KHSRP) plays an important role in cancer invasion, but the relevant mechanism is not well known. In the present study, we investigated the function and potential molecular mechanism of KHSRP in non-small cell lung cancer (NSCLC) metastasis and elucidated its clinical significance. Methods Isobaric tags for relative and absolute quantitation and the SWATH™ approach were combined with nanoliquid chromatography-tandem mass spectrometry analysis to identify metastasis-associated nucleoproteins in NSCLC. Real-time PCR and Western blot were used to screen for metastasis-associated candidate molecules. Gene knockdown and overexpression were used to investigate their functions and molecular mechanisms in lung cancer cells. Coimmunoprecipitation (Co-IP) experiments were performed to identify the interactions between candidate molecules and their interacting proteins. Gene expression and its association with multiple clinicopathologic characteristics were analyzed by immunohistochemistry (IHC) and Western blot in human lung cancer specimens. Results KHSRP was identified as a metastasis-associated candidate molecule. In NSCLC cell lines, knockdown of KHSRP significantly reduced lung cancer cell proliferation, migration, and invasion in vitro and in vivo, whereas overexpression of KHSRP did the opposite. Mechanistically, the protein heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRNPC) was identified to interact with KHSRP using Co-IP experiments. In NSCLC cell lines, overexpression of HNRNPC significantly promoted lung cancer cell proliferation, migration, and invasion in vitro and in vivo. KHSRP and HNRNPC may induce human lung cancer cell invasion and metastasis by activating the IFN-α-JAK-STAT1 signaling pathway. Drastically higher expression levels of KHSRP and HNRNPC were observed in lung cancer tissues compared to those in adjacent noncancerous tissues. Increased KHSRP and HNRNPC expression was significantly associated with advanced tumor stages and metastasis (both lymph node and distant). Kaplan-Meier survival analysis showed that patients with high KHSRP and HNRNPC expression levels were predicted to have the shortest survival times and to have a poor prognosis. Conclusions KHSRP plays an important role in NSCLC metastasis and may serve as a potential prognostic marker and novel therapeutic target for lung cancer metastasis treatment.

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