scholarly journals Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 10650-10661 ◽  
Author(s):  
Sha-sha Wang ◽  
Xiao Cen ◽  
Xin-hua Liang ◽  
Ya-ling Tang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Neck Squamous Cell Carcinoma ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Macrophage migration inhibitory factor: A promising oncogenic serological biomarker for oral squamous cell carcinoma

2021 ◽  
Vol 35 ◽  
pp. 205873842110384
Author(s):  
José Sergio Zepeda-Nuño ◽  
Evangelina Gutiérrez-Cortés ◽  
Jorge Hernández-Bello ◽  
Julián Ángeles-Sánchez ◽  
Ulises De la Cruz-Mosso ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Control Subjects

There are few reports in oral squamous cell carcinoma (OSCC) that indicate the expression of macrophage migration inhibitory factor (MIF) in tissues, serum, or saliva of patients with OSCC. The aim of this study was to evaluate the mRNA expression and protein of MIF in tissues and serum, respectively, in OSCC patients and its association with the TNM stage. A cross-sectional study was performed. Serum and tissues of 25 patients with OSCC and 25 healthy control subjects (HCS) were included to evaluate the MIF mRNA expression and protein serum levels by real-time PCR and ELISA, respectively. Serum MIF levels were significantly higher in OSCC compared with control subjects. Furthermore, in the OSCC group, MIF was significantly increased in accordance with tumor disease stage (TNM III–IV), as well as in poorly differentiated tumors. The mRNA showed significantly higher levels in HCS, as well as in more differentiated tumors. The results of this study suggest that MIF could be an indicator of severity and progression of OSCC. Further studies are required to explore the role of MIF as a serological biomarker for OSCC.

scholarly journals Serum and salivary macrophage migration inhibitory factor in patients with oral squamous cell carcinoma

2014 ◽  
Vol 8 (5) ◽  
pp. 2267-2275 ◽  
Author(s):  
MARIANA BARBOSA DE SOUZA ◽  
OTÁVIO ALBERTO CURIONI ◽  
JOSSI LEDO KANDA ◽  
MARCOS BRASILINO DE CARVALHO
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration
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