scholarly journals Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

Oncotarget ◽  
2016 ◽  
Vol 7 (47) ◽  
pp. 77152-77162 ◽  
Author(s):  
Mu Li ◽  
Chen-Yang Dai ◽  
Yu-Ning Wang ◽  
Tao Chen ◽  
Long Wang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Marital Status ◽  
Cancer Patients ◽  
Independent Prognostic Factor ◽  
Seer Database

scholarly journals Marital Status is an Independent Prognostic Factor in 7 Sites of Squamous Cell Carcinoma: A Propensity-Adjusted SEER Database Analysis

2021 ◽  
Author(s):  
Ji-li Xu ◽  
Yong Guo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Propensity Score ◽  
Marital Status ◽  
Cell Carcinoma ◽  
Propensity Score Matching ◽  
Squamous Cell ◽  
Cox Regression ◽  
Independent Prognostic Factor ◽  
Seer Database

Abstract Background: Marital status has been proved as an independent prognostic factor in many cancer types. However, no detailed investigation of marital status on squamous cell carcinoma (SCC) has been evaluated. The aim of this essay is to explore the relationship between marital status and SCC in 7 tumor sites. Methods: All patients diagnosed with SCC were collected from the SEER database (1975-2016). We analyzed the survival of all included SCC patients in four marital status. We utilized propensity-score matching analysis to balance baseline characteristics between married and unmarried SCC patients in 7 tumor sites. The influence of marital status on overall survival (OS) in each site was performed by Cox regression analysis.Results: A total of 180009 SCC patients were involved in this study. After propensity-score matching, patients in the married group were 1:1 matched with patients in the unmarried group for each sites. Married group exhibited higher 5- year OS rate than unmarried group (27.3% vs 19.8%). More precisely, being divorced and widowed were observed to be related to have worse survival than single patients in most sites. Furthermore, patients with clinical stage IV were more common in the unmarried group which having a lower proportion of receiving treatment. Conclusions: This study indicated that marital status was a significant factor for OS of SCC in 7 tumor sites. Married patients always behaved more favorable than unmarried including single, divorced, and widowed patients.

scholarly journals The Influence of Marital Status on Survival in Patients with Nasopharyngeal Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis

2019 ◽  
Author(s):  
Bin Yu ◽  
Hong Ning ◽  
Shan Xu ◽  
Li Qin ◽  
Bin-wei Lin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Marital Status ◽  
Psychosocial Support ◽  
Independent Prognostic Factor ◽  
Elderly Subjects ◽  
Seer Database ◽  
Increased Risk ◽  
Cox Proportional Hazard Regression ◽  
End Results

Abstract Purpose: To assess the influence of marital status on survival in patients with nasopharyngeal carcinoma (NPC). Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to analyze 5477 patients who were diagnosed with NPC from 2004 to 2016. Kaplan–Meier survival analysis and Cox proportional hazard regression were used to analyze the influences of marital status on cause-specific survival (CSS) and overall survival (OS). Subgroup analyses was used to assess the influences of marital status on CSS based on different factors. Results: The 5477 patients were divided into three groups, with 61.5%, 22.4%, and 16.1% of patients being married, single/unmarried, and separated/widowed/divorced, respectively. The separated/widowed/divorced group were more likely to be female ( P <0.001); had the highest proportion of elderly subjects ( P <0.001); were mostly Caucasian ( P <0.001); had pathological grading I/II ( P <0.001); were likely to receive surgery ( P =0.032); and were registered at the northeast, north central, and south ( P < 0.001) regions. The 5-year CSS was 92.6%, 92.4%, and 85.1% in the married, single/unmarried, and separated/widowed/divorced groups, respectively ( P <0.001); and respective 5-year OS was 60.7%, 54.6%, and 40.1% ( P <0.001). Marital status was the independent prognostic factor for NPC. Compared with married patients, separated/widowed/divorced patients had a significantly increased risk of NPC-related death (hazard ratio [HR]=2.180, 95% confidence interval [CI] 1.721–2.757, P <0.001). The single/unmarried ( P =0.355) group had a similar CSS as that of the group. Conclusion: Marital status is an independent prognostic factor for survival of NCP patients. Separated/widowed/divorced status increases the risk of NPC mortality; hence, more social and psychosocial support should be given to patients who are separated, widowed, or divorced.

LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy

2016 ◽  
Vol 103 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Ben Huang ◽  
Mengdong Ni ◽  
Chen Chen ◽  
Guoxiang Cai ◽  
Sanjun Cai
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Preoperative Radiotherapy ◽  
Independent Prognostic Factor ◽  
Stage Iii ◽  
Seer Database ◽  
Node Ratio

Purpose Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT. Methods We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome. Results A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p<0.001). In the multivariate analysis without yp-LODDS, yp-LNR was an independent prognostic factor (hazard ratio [HR] 2.006, 95% confidence interval [CI] 1.619-2.484, p<0.001). However, after adjusting for yp-LODDS, yp-LNR was no longer associated with CSS (p = 0.393), and yp-LODDS was identified as an independent prognostic factor (HR 1.274, 95% CI 1.069-1.520, p = 0.007). Conclusions The prognostic value of yp-LNR can be confounded by yp-LODDS. In stage III rectal cancer patients treated with pre-RT, yp-LODDS has superior discrimination power over yp-LNR and can more accurately evaluate CSS.

scholarly journals The Effect of Marital Status on Survival of Patients with Gastrointestinal Stromal Tumors: A SEER Database Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Song ◽  
Chuan Tian
Keyword(s):  
Prognostic Factor ◽  
Marital Status ◽  
Gastrointestinal Stromal Tumors ◽  
Cox Regression ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Stromal Tumors ◽  
Kaplan Meier ◽  
Risk Of Cancer ◽  
The Impact

Background. Marital status has been reported to be a prognostic factor in multiple malignancies. However, its prognostic value on gastrointestinal stromal tumors (GISTs) have not yet been determined. The objective of the present analysis was to assess the effects of marital status on survival in patients with GISTs. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was used to analyze 6195 patients who were diagnosed with GISTs from 2001 to 2014. We also use Kaplan-Meier analysis and Cox regression to analyze the impact of marital status on cancer-specific survival (CSS). Results. Patients in the married group had more frequency in white people, more high/moderate grade tumors, and were more likely to receive surgery. Widowed patients had a higher proportion of women, a greater proportion of older patients (>60 years), and more common site of the stomach. Multivariate analysis demonstrated that marital status was an independent prognostic factor for GISTs (P<0.001). Married patients had better CSS than unmarried patients (P<0.001). Subgroup analysis suggested that widowed patients had the lowest CSS compared with all other patients. Conclusions. Marital status is a prognostic factor for survival in patients with GISTs, and widowed patients are at greater risk of cancer-specific mortality.

scholarly journals Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients

Oncotarget ◽  
2016 ◽  
Vol 8 (36) ◽  
pp. 60015-60024 ◽  
Author(s):  
Na Liu ◽  
Thomas R. Cox ◽  
Weiyingqi Cui ◽  
Gunnar Adell ◽  
Birgitta Holmlund ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Lysyl Oxidase ◽  
Independent Prognostic Factor ◽  
Nuclear Expression ◽  
Oxidase Enzyme
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