scholarly journals Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (47) ◽  
pp. 76793-76805 ◽  
Author(s):  
Shotaro Ando ◽  
Jun-ichi Kawada ◽  
Takahiro Watanabe ◽  
Michio Suzuki ◽  
Yoshitaka Sato ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Natural Killer Cell ◽  
Tumor Growth ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Barr Virus ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Epstein Barr

scholarly journals Anti‐tumor effects of suberoylanilide hydroxamic acid on Epstein–Barr virus‐associated T cell and natural killer cell lymphoma

2014 ◽  
Vol 105 (6) ◽  
pp. 713-722 ◽  
Author(s):  
Mohammed N.A. Siddiquey ◽  
Hikaru Nakagawa ◽  
Seiko Iwata ◽  
Tetsuhiro Kanazawa ◽  
Michio Suzuki ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Hydroxamic Acid ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Suberoylanilide Hydroxamic Acid ◽  
Barr Virus ◽  
Epstein Barr

Epstein-Barr virus-negative extranodal “true” natural killer-cell lymphoma harbouring a KDM6A mutation

2017 ◽  
Vol 36 (1) ◽  
pp. 328-335 ◽  
Author(s):  
Naoko Tsuyama ◽  
Reimi Asaka ◽  
Akito Dobashi ◽  
Satoko Baba ◽  
Yuko Mishima ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Natural Killer Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

An Extranodal Nasal Natural Killer/T-Cell Lymphoma With Isochromosome 7q10 as the Sole Cytogenetic Aberration Was Initially Diagnosed Via Bone Marrow Biopsy

2007 ◽  
Vol 131 (11) ◽  
pp. 1709-1714
Author(s):  
Huan-You Wang ◽  
Kathleen S. Wilson ◽  
Robert W. McKenna ◽  
Yin Xu ◽  
Nitin Karandikar
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Bone Marrow Biopsy ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Barr Virus ◽  
Epstein Barr

Abstract We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and “sinusitis” of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+ (dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus– encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of his right nasal vestibule demonstrated an atypical lymphoid infiltrate, which was cytoplasmic CD3+, CD56+, and Epstein-Barr virus–encoded RNA positive, consistent with an extranodal nasal natural killer cell lymphoma. Conventional cytogenetic studies of the bone marrow revealed isochromosome 7q10 [i(7)(q10)] as the sole chromosomal aberration. To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma.

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