scholarly journals Integrative analysis of protein-coding and non-coding RNAs identifies clinically relevant subtypes of clear cell renal cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (50) ◽  
pp. 82671-82685 ◽  
Author(s):  
Zongcheng Li ◽  
Yaowen Chen ◽  
Shuofeng Hu ◽  
Jian Zhang ◽  
Jiaqi Wu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Integrative Analysis ◽  
Cell Renal Cell Carcinoma ◽  
Protein Coding ◽  
Non Coding Rnas

scholarly journals Prognostic significance of long non-coding RNAs in clear cell renal cell carcinoma

Medicine ◽  
2019 ◽  
Vol 98 (40) ◽  
pp. e17276 ◽  
Author(s):  
Yan Wang ◽  
Zhan Li ◽  
Wei Li ◽  
Le Zhou ◽  
Yuehua Jiang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Significance ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rnas

863 Identification and functional analysis of novel long non-coding RNAs in clear cell renal cell carcinoma

2015 ◽  
Vol 14 (2) ◽  
pp. e863 ◽  
Author(s):  
J. Ellinger ◽  
J.J.C. Blondeau ◽  
M. Deng ◽  
I. Syring ◽  
S. Schrödter ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Functional Analysis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rnas

764 Integrative analysis of clear cell renal cell carcinoma

2013 ◽  
Vol 12 (1) ◽  
pp. e764-e765
Author(s):  
Y. Sato ◽  
S. Maekawa ◽  
Y. Okuno ◽  
Y. Shiraishi ◽  
A. Sato ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Integrative Analysis ◽  
Cell Renal Cell Carcinoma

Abstract 3184: Integrative analysis of clear cell renal cell carcinoma.

2013 ◽  
Author(s):  
Yusuke Sato ◽  
Shigekatsu Maekawa ◽  
Yusuke Okuno ◽  
Yuichi Shiraishi ◽  
Aiko Sato ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Integrative Analysis ◽  
Cell Renal Cell Carcinoma

scholarly journals Dysregulation of Long Non-coding RNAs and mRNAs in Plasma of Clear Cell Renal Cell Carcinoma Patients Using Microarray and Bioinformatic Analysis

2020 ◽  
Vol 10 ◽  
Author(s):  
Bing Zhang ◽  
Wei Chu ◽  
Feifei Wen ◽  
Li Zhang ◽  
Lixia Sun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Biological Function ◽  
Clear Cell ◽  
Differentially Expressed ◽  
Healthy Controls ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rnas

Objective: The roles of long non-coding RNAs (lncRNAs) in the diagnosis of clear cell renal cell carcinoma (ccRCC) are still not well-defined. We aimed to identify differentially expressed lncRNAs and mRNAs in plasma of ccRCC patients and health controls systematically.Methods: Expression profile of plasma lncRNAs and mRNAs in ccRCC patients and healthy controls was analyzed based on microarray assay. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-based approaches were used to investigate biological function and signaling pathways mediated by the differentially expressed mRNAs. SOCS2-AS1 was selected for validation using Real-Time PCR. The differentially expressed lncRNAs and mRNAs were further compared with E-MTAB-1830 datasets using Venn and the NetworkAnalyst website. The GEPIA and ULCAN websites were utilized for the evaluation of the expression level of differentially expressed mRNA and their association with overall survival (OS).Results: A total of 3,664 differentially expressed lncRNAs were identified in the plasma of ccRCC patients, including 1,511 up-regulated and 2,153 down-regulated lncRNAs (fold change ≥2 and P < 0.05), respectively. There were 2,268 differentially expressed mRNAs, including 932 up-regulated mRNAs and 1,336 down-regulated mRNAs, respectively (fold change ≥2 and P < 0.05). Pathway analysis based on deregulated mRNAs was mainly involved in melanogenesis and Hippo signaling pathway (P < 0.05). In line with the lncRNA microarray findings, the SOCS2-AS1 was down-regulated in ccRCC plasma and tissues, as well as in cell lines. Compared with the E-MTAB-1830 gene expression profiles, we identified 18 lncRNAs and 87 mRNAs differently expressed in both plasma and neoplastic tissues of ccRCC. The expression of 10 mRNAs (EPB41L4B, CCND1, GGT1, CGNL1, CYSLTR1, PLAUR, UGT3A1, PROM2, MUC12, and PCK1) was correlated with the overall survival (OS) rate in ccRCC patients based on the GEPIA and ULCAN websites.Conclusions: We firstly reported differentially expressed lncRNAs in ccRCC patients and healthy controls systemically. Several differentially expressed lncRNAs and mRNAs were identified, which might serve as diagnostic or prognostic markers. The biological function of these lncRNAs and mRNAs should be further validated. Our study may contribute to the future treatment of ccRCC and provide novel insights into cancer biology.

scholarly journals MicroRNAs Possibly Involved in the Development of Bone Metastasis in Clear-Cell Renal Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1554
Author(s):  
Lisa Kinget ◽  
Eduard Roussel ◽  
Diether Lambrechts ◽  
Bram Boeckx ◽  
Loïc Vanginderhuysen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Bone Metastasis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Protein Coding ◽  
Rna Molecules ◽  
Regulatory Functions ◽  
Substantial Morbidity

Bone metastasis in clear-cell renal cell carcinoma (ccRCC) leads to substantial morbidity through skeletal related adverse events and implicates worse clinical outcomes. MicroRNAs (miRNA) are small non-protein coding RNA molecules with important regulatory functions in cancer development and metastasis. In this retrospective analysis we present dysregulated miRNA in ccRCC, which are associated with bone metastasis. In particular, miR-23a-3p, miR-27a-3p, miR-20a-5p, and miR-335-3p specifically correlated with the earlier appearance of bone metastasis, compared to metastasis in other organs. In contrast, miR-30b-3p and miR-139-3p were correlated with less occurrence of bone metastasis. These miRNAs are potential biomarkers and attractive targets for miRNA inhibitors or mimics, which could lead to novel therapeutic possibilities for bone targeted treatment in metastatic ccRCC.

scholarly journals Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1580 ◽  
Author(s):  
Dominik A. Barth ◽  
Ondrej Slaby ◽  
Christiane Klec ◽  
Jaroslav Juracek ◽  
Rares Drula ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Current Knowledge ◽  
Predictive Biomarkers ◽  
Treatment Schedule ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rnas

Renal cell carcinoma (RCC) is a relatively rare malignancy of the urinary tract system. RCC is a heterogenous disease in terms of underlying histology and its associated underlying pathobiology, prognosis and treatment schedule. The most prevalent histological RCC subtype is clear-cell renal cell carcinoma (ccRCC), accounting for about 70–80% of all RCCs. Though the pathobiology and treatment schedule for ccRCC are well-established, non-ccRCC subtypes account for 20%–30% of RCC altogether, and their underlying molecular biology and treatment options are poorly defined. The class of non-coding RNAs—molecules that are generally not translated into proteins—are new cancer drivers and suppressors in all types of cancer. Of these, small non-coding microRNAs (miRNAs) contribute to carcinogenesis by regulating posttranscriptional gene silencing. Additionally, a growing body of evidence supports the role of long non-coding RNAs (lncRNAs) in cancer development and progression. Most studies on non-coding RNAs in RCC focus on clear-cell histology, and there is a relatively limited number of studies on non-ccRCC subtypes. The aim of this review is to give an overview of the current knowledge regarding the role of non-coding RNAs (including short and long non-coding RNAs) in non-ccRCC and to highlight possible implications as diagnostic, prognostic and predictive biomarkers.

scholarly journals Identification of novel long non-coding RNAs in clear cell renal cell carcinoma

2015 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Jasmine Blondeau ◽  
Mario Deng ◽  
Isabella Syring ◽  
Sarah Schrödter ◽  
Doris Schmidt ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rnas
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