scholarly journals IL-1 drives breast cancer growth and bone metastasis in vivo

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 75571-75584 ◽  
Author(s):  
Ingunn Holen ◽  
Diane V. Lefley ◽  
Sheila E. Francis ◽  
Sarah Rennicks ◽  
Steven Bradbury ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Estrogen Deprivation and Inhibition of Breast Cancer Growth in Vivo through Activation of the Orphan Nuclear Receptor Liver X Receptor

2007 ◽  
Vol 21 (8) ◽  
pp. 1781-1790 ◽  
Author(s):  
Haibiao Gong ◽  
Ping Guo ◽  
Yonggong Zhai ◽  
Jie Zhou ◽  
Hirdesh Uppal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver X Receptor ◽  
Cancer Growth ◽  
Estrogen Metabolism ◽  
Endocrine Disorders ◽  
Estrogen Deprivation ◽  
Uterine Epithelial Cell ◽  
Hepatic Expression ◽  
Breast Cancer Growth

Abstract Estrogen plays an important role in normal physiology. It is also a risk factor for breast cancer, and antiestrogen therapies have been shown to be effective in the treatment and prevention of breast cancers. The liver is important for estrogen metabolism, and a compromised liver function has been linked to hyperestrogenism in patients. In this report, we showed that the liver X receptor (LXR) controls estrogen homeostasis by regulating the basal and inducible hepatic expression of estrogen sulfotransferase (Est, or Sult1e1), an enzyme critical for metabolic estrogen deactivation. Genetic or pharmacological activation of LXR resulted in Est induction, which in turn inhibited estrogen-dependent uterine epithelial cell proliferation and gene expression, as well as breast cancer growth in a nude mouse model of tumorigenicity. We further established that Est is a transcriptional target of LXR, and deletion of the Est gene in mice abolished the LXR effect on estrogen deprivation. Interestingly, Est regulation by LXR appeared to be liver specific, further underscoring the role of liver in estrogen metabolism. Activation of LXR failed to induce other major estrogen-metabolizing enzymes, suggesting that the LXR effect on estrogen metabolism is Est specific. In summary, our results have revealed a novel mechanism controlling estrogen homeostasis in vivo and may have implications for drug development in the treatment of breast cancer and other estrogen-related cancerous endocrine disorders.

scholarly journals Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo

2020 ◽  
Vol 121 ◽  
pp. 109502 ◽  
Author(s):  
Zhe Liu ◽  
Xianmin Ge ◽  
Yuchen Gu ◽  
Yingying Huang ◽  
Hao Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Small Molecule ◽  
Cancer Growth ◽  
Breast Cancer Growth

Photodynamic acidification therapy to reduce triple negative breast cancer growth in vivo.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12574-e12574 ◽  
Author(s):  
Nuha Buchanan Kadri ◽  
Matthew Gdovin ◽  
Nizar Alyassin ◽  
Justin Avila ◽  
Aryana Cruz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 47675-47690 ◽  
Author(s):  
Matthew McConnell ◽  
Shengmei Feng ◽  
Wei Chen ◽  
Guochun Zhu ◽  
Dejun Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Atpase Activity ◽  
Proton Pump ◽  
Cancer Growth ◽  
Mtorc1 Pathway ◽  
Breast Cancer Growth

scholarly journals Vitamin D Deficiency Promotes Human Breast Cancer Growth in a Murine Model of Bone Metastasis

2010 ◽  
Vol 70 (5) ◽  
pp. 1835-1844 ◽  
Author(s):  
Li Laine Ooi ◽  
Hong Zhou ◽  
Robert Kalak ◽  
Yu Zheng ◽  
Arthur D. Conigrave ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Bone Metastasis ◽  
Vitamin D Deficiency ◽  
Murine Model ◽  
Human Breast Cancer ◽  
Cancer Growth ◽  
Human Breast ◽  
Breast Cancer Growth

scholarly journals Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis

Oncogene ◽  
2016 ◽  
Vol 35 (43) ◽  
pp. 5597-5607 ◽  
Author(s):  
J Z Zhou ◽  
M A Riquelme ◽  
S Gu ◽  
R Kar ◽  
X Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Growth ◽  
Breast Cancer Growth ◽  
Connexin Hemichannels

Specific endothelin-A-receptor antagonist ZD4054 inhibits breast cancer growth in vitro and in vivo

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
M Smollich ◽  
M Götte ◽  
J Fischgräbe ◽  
I Radke ◽  
L Macedo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Receptor Antagonist ◽  
Cancer Growth ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Breast Cancer Growth
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