scholarly journals SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 75561-75570 ◽  
Author(s):  
Yongsheng Huang ◽  
Wenting Wu ◽  
Meng Nie ◽  
Chuang Li ◽  
Lin Wang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Case Control Studies

Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case–control studies

2012 ◽  
Vol 40 (6) ◽  
pp. 3943-3952 ◽  
Author(s):  
Li Liu ◽  
Lin Miao ◽  
Guozhong Ji ◽  
Fulin Qiang ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Case Control Studies

scholarly journals Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis

2015 ◽  
Vol 19 (2) ◽  
pp. 308-317 ◽  
Author(s):  
Manuela Chiavarini ◽  
Liliana Minelli ◽  
Roberto Fabiani
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Pooled Analysis ◽  
Case Control ◽  
Dietary Factors ◽  
Colorectal Cancer Risk ◽  
Risk Estimate ◽  
Case Control Studies

AbstractObjectiveColorectal cancer shows large incidence variations worldwide that have been attributed to different dietary factors. We conducted a meta-analysis on the relationship between garlic consumption and colorectal cancer risk.DesignWe systematically reviewed publications obtained by searching ISI Web of Knowledge, MEDLINE and EMBASE literature databases. We extracted the risk estimate of the highest and the lowest reported categories of intake from each study and conducted meta-analysis using a random-effects model.ResultsThe pooled analysis of all fourteen studies, seven cohort and seven case–control, indicated that garlic consumption was not associated with colorectal cancer risk (OR=0·93; 95 % CI 0·82, 1·06, P=0·281; I2=83·6 %, P≤0·001). Separate analyses on the basis of cancer sites and sex also revealed no statistically significant effects on cancer risk. However, when separately analysed on the basis of study type, we found that garlic was associated with an approximately 37 % reduction in colorectal cancer risk in the case–control studies (combined risk estimate=0·63, 95 % CI 0·48, 0·82, P=0·001; I2=75·6 %, P≤0·001).ConclusionsOur results suggest that consumption of garlic is not associated with a reduced colorectal cancer risk. Further investigations are necessary to clarify the discrepancy between results obtained from different types of epidemiological studies.

scholarly journals Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies

2012 ◽  
Vol 16 (2) ◽  
pp. 346-357 ◽  
Author(s):  
Guowei Li ◽  
Defu Ma ◽  
Yumei Zhang ◽  
Wei Zheng ◽  
Peiyu Wang
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Case Control Studies ◽  
The Relationship

AbstractObjectiveSeparate meta-analyses based on case–control and cohort studies have reported different results on the relationship between coffee consumption and colorectal cancer risk. To clarify the effect of coffee intake on colorectal cancer risk, we performed a meta-analysis based on both case–control and cohort studies.DesignReview study.SettingWe identified case–control and cohort studies related to coffee consumption and colorectal cancer risk listed on MEDLINE, the Cochrane Controlled Trials Register, EMBASE, Science Citation Index and PubMed (until May 2011).SubjectsResearch literature on the relationship between coffee consumption and colorectal cancer risk.ResultsTwenty-five case–control (15 522 cases) and sixteen cohort studies (10 443 cases) were included in the meta-analysis. Comparing the highest v. the lowest/non category of coffee consumption, the combined results from case–control studies showed a significant relationship with colorectal cancer (OR = 0·85, 95 % CI 0·75, 0·97) and colon cancer (OR = 0·79, 95 % CI 0·67, 0·95), but not rectal cancer (OR = 0·95, 95 % CI 0·79, 1·15). For cohort studies, there was a slight suggestion of an inverse association with colorectal cancer (relative ratio = 0·94; 95 % CI 0·88, 1·01) and colon cancer (OR = 0·93, 95 % CI 0·86, 1·01), rather than rectal cancer (OR = 0·98, 95 % CI 0·88, 1·09). In subgroup analyses using case–control studies, significant inverse associations were found in females for colorectal cancer and in Europe for colorectal and colon cancer, while the subgroup analyses of cohort studies found that coffee drinks substantially decreased risk of colon cancer only in Asian women.ConclusionsResults from case–control studies suggest coffee consumption can significantly decrease the risks of colorectal cancer and colon cancer, especially in Europe and for females.

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