scholarly journals Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 80019-80032 ◽  
Author(s):  
Xu Ji ◽  
Chao Guan ◽  
Xuejun Jiang ◽  
Hong Li
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sample Type

scholarly journals Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis

2021 ◽  
Vol 11 (6) ◽  
pp. 568
Author(s):  
Óscar Rapado-González ◽  
Cristina Martínez-Reglero ◽  
Ángel Salgado-Barreira ◽  
Laura Muinelo-Romay ◽  
Juan Muinelo-Lorenzo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Likelihood Ratio ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Epigenetic Mechanism ◽  
Cochrane Library

DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis.

Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies

Endoscopy ◽  
2017 ◽  
Vol 49 (09) ◽  
pp. 848-854 ◽  
Author(s):  
Peter Wu ◽  
Michal Szczesniak ◽  
Julia Maclean ◽  
Lennart Choo ◽  
Harry Quon ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Characteristic Curve ◽  
Diagnostic Tools ◽  
Cross Sectional ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe ◽  
Dysphagic Patients

Abstract Background and aims Chemoradiotherapy for head and neck cancer (HNC) with/without laryngectomy commonly causes dysphagia. Pharyngoesophageal junction (PEJ) stricturing is an important contributor. We aimed to validate a functional lumen imaging probe (the EndoFLIP system) as a tool for quantitating pretreatment PEJ distensibility and treatment-related changes in HNC survivors with dysphagia and to evaluate the diagnostic accuracy of EndoFLIP-derived distensibility in detecting PEJ strictures. Methods We studied 34 consecutive HNC survivors with long-term (> 12 months) dysphagia who underwent endoscopic dilation for suspected strictures. Twenty non-dysphagic patients undergoing routine endoscopy served as controls. PEJ distensibility was measured at endoscopy with the EndoFLIP system pre- and post-dilation. PEJ stricture was defined as the presence of a mucosal tear post-dilation. Results PEJ stricture was confirmed in 22/34 HNC patients (65 %). During distension up to 60 mmHg, the mean EndoFLIP-derived narrowest cross-sectional area (nCSA) in HNC patients with strictures, without strictures, and in controls were 58 mm2 (95 % confidence interval [CI] 22 to 118), 195 mm2 (95 %CI 129 to 334), and 227 mm2 (95 %CI 168 to 316), respectively. A cutoff of 114 mm2 for the nCSA at the PEJ had perfect diagnostic accuracy in detecting strictures (area under the receiver operating characteristic curve = 1). In patients with strictures, a single session of dilation increased the nCSA by 29 mm2 (95 %CI 20 to 37; P < 0.001). In patients with no strictures, dilation caused no change in the nCSA (mean difference 13 mm2 [95 %CI −4 to 30]; P = 0.13). Conclusions EndoFLIP is a highly accurate technique for the detection of PEJ strictures. EndoFLIP may complement conventional diagnostic tools in the detection of pharyngeal outflow obstruction.

scholarly journals Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer

2013 ◽  
Vol 105 (2) ◽  
pp. 79-83 ◽  
Author(s):  
Rita Carvalho ◽  
Miguel Areia ◽  
Daniel Brito ◽  
Sandra Saraiva ◽  
Susana Alves ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients

2019 ◽  
Vol 12 (4) ◽  
pp. 255-270 ◽  
Author(s):  
Rafael Guerrero-Preston ◽  
Fahcina Lawson ◽  
Sebastian Rodriguez-Torres ◽  
Maartje G. Noordhuis ◽  
Francesca Pirini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Racial Disparities ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Social Determinants ◽  
Immune Signatures

Abstract 645: DNA methylation marker discovery for the prediction of nodal metastases in head and neck cancer.

2013 ◽  
Author(s):  
Martijn Clausen ◽  
Lieuwe J. Melchers ◽  
Leonie Bruine de Bruin ◽  
Mirjam F. Mastik ◽  
Lorian Slagter-Menkema ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nodal Metastases ◽  
Methylation Marker ◽  
Marker Discovery

Diagnostic accuracy of probe-based confocal laser endomicroscopy in Lugol-unstained esophageal superficial lesions of patients with head and neck cancer

2017 ◽  
Vol 85 (6) ◽  
pp. 1195-1207 ◽  
Author(s):  
Adriana Vaz Safatle-Ribeiro ◽  
Elisa Ryoka Baba ◽  
Sheila Friedrich Faraj ◽  
Juliana Trazzi Rios ◽  
Marcelo Simas de Lima ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser
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