scholarly journals Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 70364-70377 ◽  
Author(s):  
Si Li ◽  
Hai-Yan Zhang ◽  
Zhen-Xian Du ◽  
Chao Li ◽  
Ming-Xin An ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Beclin 1 ◽  
Mesenchymal Transition ◽  
Thyroid Cancer Cells

scholarly journals miR-32-5p Inhibits the Proliferation, Migration and Invasion of Thyroid Cancer Cells by Regulating Twist1

2021 ◽  
Author(s):  
Qing Liu ◽  
Ouyang Li ◽  
Chi Zhou ◽  
Yu Wang ◽  
Chunxue He ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Transition Process ◽  
Underlying Mechanism ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Thyroid Cancer Cells

Abstract Background: Thyroid cancer is the most prevalent malignancy and one of the leading causes of cancer-related deaths. Recent studies have revealed that microRNAs (miRNAs) play an important role in tumorigenesis in various cancer types by affecting the expression of its targets. However, the role of miR-32-5p in thyroid cancer remains limited. Methods: In this study, we attempt to explore the role of miR-32-5p in thyroid cancer and elucidate the underlying mechanism. Expression of miR-32-5p was determined by quantitative reverse transcription PCR. Functional assays were performed by CCK-8 assay, cell colony assay, cell apoptosis assay, cell migration and invasion assays, cell cycle assay and luciferase assay. Protein expression was analyzed by Western blot.Results: In the present study, the role of miR-32-5p in thyroid cancer was firstly explored. It is found that miR-32-5p was downregulated in thyroid cancer tissues and cells. Overexpression of miR-32-5p inhibited thyroid cancer cells proliferation, migration, invasion and epithelial‐mesenchymal transition process; while suppression of miR-32-5p exhibited an opposite effect on thyroid cancer cells. In addition, In addition, a luciferase assay showed Twist1 was identified as a direct target of miR-32-5p in thyroid cancer, and further study showed that restoration of Twist1 attenuated the biological effect of miR-32-5p on thyroid cancer cells. Conclusion: In conclusion, our results demonstrated miR-32-5p functions as a tumor suppressor by targeting Twist1 in thyroid cancer, providing a novel insight into thyroid cancer therapy.

Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells

2016 ◽  
Vol 419 ◽  
pp. 113-123 ◽  
Author(s):  
Min Ji Jeon ◽  
Won Gu Kim ◽  
Seonhee Lim ◽  
Hyun-Jeung Choi ◽  
Soyoung Sim ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Lipoic Acid ◽  
Epithelial Mesenchymal Transition ◽  
Alpha Lipoic Acid ◽  
Mesenchymal Transition ◽  
Thyroid Cancer Cells

REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells

2019 ◽  
Vol 64 ◽  
pp. 109412 ◽  
Author(s):  
Muhammad Zeeshan Bhatti ◽  
Linian Pan ◽  
Tianzhen Wang ◽  
Peilin Shi ◽  
Lei Li
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Thyroid Cancer Cells
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