scholarly journals Circulating vascular endothelial growth factor (VEGF) as predictive factor of progression-free survival in patients with advanced chordoma receiving sorafenib: an analysis from a phase II trial of the french sarcoma group (GSF/GETO)

Oncotarget ◽  
2016 ◽  
Vol 7 (45) ◽  
pp. 73984-73994 ◽  
Author(s):  
Loic Lebellec ◽  
François Bertucci ◽  
Emmanuelle Tresch-Bruneel ◽  
Emmanuelle Bompas ◽  
Yves Toiron ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Phase Ii ◽  
Predictive Factor ◽  
Phase Ii Trial ◽  
Progression Free Survival ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Endothelial Growth Factor

Functional and prognostic influence of receptor polymorphisms in the vascular endothelial growth factor system in colorectal cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15032-e15032
Author(s):  
T. Hansen ◽  
K. G. Spindler ◽  
D. A. Olsen ◽  
R. F. Andersen ◽  
J. Lindebjerg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Protein Concentration ◽  
Progression Free Survival ◽  
Vascular Endothelial ◽  
Malignant Tumours ◽  
Free Survival ◽  
Endothelial Growth Factor

e15032 Background: The vascular endothelial growth factor (VEGF) system plays a key role in the angiogenic process ensuring a sufficient blood supply to the growth of malignant tumours. The clinical importance of single nucleotide polymorphisms (SNP's) in the VEGF receptors is still unknown. The aim of this study was to investigate the functional and prognostic influence of the V297I C/T and the -604 T/C SNP's in the VEGFR-2 gene, in tumour and normal tissue from colorectal cancer patients. Methods: Blood samples and tissue were collected from 110 patients, surgically resected for colorectal cancer. Genomic DNA was isolated from whole blood, and SNP's were analysed by PCR. Gene expression analysis was performed by RT-PCR and protein analysis was performed by ELISA. Progression free survival according to genotypes was compared using the Kaplan-Meier method and the logrank test. Results: Median gene expression according to the CC genotype of the -604 T/C SNP, were significantly higher than the median gene expression of the TT genotype (p = 0.045) and the TC genotype (p = 0.033) in CRC tissue. Regarding the V297I C/T SNP, median protein concentration according to the CT genotype was significantly higher than the median protein concentration of the CC genotype, p = 0.005. The CC genotype held prognostic information compared to CT and TT genotypes for both SNP's, p<0.05. Conclusions: The V297I C/T SNP seems to have a functional influence on the VEGFR-2 protein level, and the -604 T/C SNP on the gene expression level in CRC patients. The results furthermore indicate a prognostic influence of both SNP's on progression-free survival. No significant financial relationships to disclose.

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