scholarly journals Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 75235-75260 ◽  
Author(s):  
Alejandro Vazquez-Martin ◽  
Olga V. Anatskaya ◽  
Alessandro Giuliani ◽  
Jekaterina Erenpreisa ◽  
Sui Huang ◽  
...  
Keyword(s):  
Somatic Polyploidy

scholarly journals CYTOGENETIC STUDIES IN NORTH AMERICAN MINNOWS (CYPRINIDAE). IV. SOMATIC POLYPLOIDY IN GILA BICOLOR

1977 ◽  
Vol 19 (4) ◽  
pp. 657-662 ◽  
Author(s):  
John C. Avise ◽  
John R. Gold
Keyword(s):  
North American ◽  
Kidney Tissue ◽  
Single Individual ◽  
Somatic Polyploidy ◽  
Polyploid Cells ◽  
Cytogenetic Studies ◽  
Cytological Mechanism ◽  
In Cells

The kidney tissue of a single individual of the California minnow Gila bicolor (Girard) contained polyploid cells in about 1.7% frequency. Chromosome spreads of triploid, tetraploid, hexaploid, octaploid, and dodecaploid cells were observed and may have arisen through endoreduplication of ancestral diploid and triploid cells. The cytological mechanism producing the triploid cells is unknown. Diplochromosomes were not present. The distribution of ploidy in cells of this individual is not random. In particular, cells having undergone one round of chromosomal increase appear increasingly susceptible to additional rounds of chromosomal gain.

A Case of Somatic Polyploidy

Nature ◽  
1963 ◽  
Vol 199 (4898) ◽  
pp. 1115-1116 ◽  
Author(s):  
H. WALLACE
Keyword(s):  
Somatic Polyploidy

Somatic polyploidy and its consequences for flower coloration and flower morphology in azalea

2001 ◽  
Vol 20 (7) ◽  
pp. 583-590 ◽  
Author(s):  
S. Schepper ◽  
L. Leus ◽  
M. Mertens ◽  
P. Debergh ◽  
E. Van Bockstaele ◽  
...  
Keyword(s):  
Flower Morphology ◽  
Somatic Polyploidy

Relationship of hepatocyte ploidy levels with body size and growth rate in mammals

Genome ◽  
2001 ◽  
Vol 44 (3) ◽  
pp. 350-360 ◽  
Author(s):  
A E Vinogradov ◽  
O V Anatskaya ◽  
B N Kudryavtsev
Keyword(s):  
Growth Rate ◽  
Body Size ◽  
Metabolic Rate ◽  
Body Mass ◽  
Ploidy Level ◽  
Safety Margin ◽  
Postnatal Growth ◽  
Ploidy Levels ◽  
Metabolic Scope ◽  
Somatic Polyploidy

To elucidate possible causes of the elevation of genome number in somatic cells, hepatocyte ploidy levels were measured cytofluorimetrically and related to the organismal parameters (body size, postnatal growth rate, and postnatal development type) in 53 mammalian species. Metabolic scope (ratio of maximal metabolic rate to basal metabolic rate) was also included in 23 species. Body masses ranged 105 times, and growth rate more than 30 times. Postnatal growth rate was found to have the strongest effect on the hepatocyte ploidy. At a fixed body mass the growth rate closely correlates (partial correlation analysis) with the cell ploidy level (r = 0.85, P < 10–6), whereas at a fixed growth rate body mass correlates poorly with ploidy level (r = –0.38, P < 0.01). The mature young (precocial mammals) of the species have, on average, a higher cell ploidy level than the immature-born (altricial) animals. However, the relationship between precocity of young and cell ploidy levels disappears when the influences of growth rate and body mass are removed. Interspecies variability of the hepatocyte ploidy levels may be explained by different levels of competition between the processes of proliferation and differentiation in cells. In turn, the animal differences in the levels of this competition are due to differences in growth rate. A high negative correlation between the hepatocyte ploidy level and the metabolic scope indicates a low safety margin of organs with a high number of polyploid cells. This fact allows us to challenge a common opinion that increasing ploidy enhances the functional capability of cells or is necessary for cell differentiation. Somatic polyploidy can be considered a "cheap" solution of growth problems that appear when an organ is working at the limit of its capabilities.Key words: genome number, somatic polyploidy, nuclear ploidy, multinuclearity, metabolic scope.

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