scholarly journals Impact of label-free technologies in head and neck cancer circulating tumour cells

Oncotarget ◽  
2016 ◽  
Vol 7 (44) ◽  
pp. 71223-71234 ◽  
Author(s):  
Arutha Kulasinghe ◽  
Liz Kenny ◽  
Chris Perry ◽  
Jean-Paul Thiery ◽  
Lidija Jovanovic ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Label Free

scholarly journals Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 367 ◽  
Author(s):  
Vanathi Perumal ◽  
Tammy Corica ◽  
Arun Dharmarajan ◽  
Zhonghua Sun ◽  
Satvinder Dhaliwal ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Primary Tumour ◽  
Personalised Medicine ◽  
Venous Blood ◽  
Tumour Cells ◽  
Treatment Modalities ◽  
Circulating Tumour Cells ◽  
Cancer Management

Head and neck cancer is the seventh most common cancer in Australia and globally. Despite the current improved treatment modalities, there is still up to 50–60% local regional recurrence and or distant metastasis. High-resolution medical imaging technologies such as PET/CT and MRI do not currently detect the early spread of tumour cells, thus limiting the potential for effective minimal residual detection and early diagnosis. Circulating tumour cells (CTCs) are a rare subset of cells that escape from the primary tumour and enter into the bloodstream to form metastatic deposits or even re-establish themselves in the primary site of the cancer. These cells are more aggressive and accumulate gene alterations by somatic mutations that are the same or even greater than the primary tumour because of additional features acquired in the circulation. The potential application of CTC in clinical use is to acquire a liquid biopsy, by taking a reliable minimally invasive venous blood sample, for cell genotyping during radiotherapy treatment to monitor the decline in CTC detectability, and mutational changes in response to radiation resistance and radiation sensitivity. Currently, very little has been published on radiation therapy, CTC, and circulating cancer stem cells (CCSCs). The prognostic value of CTC in cancer management and personalised medicine for head and neck cancer radiotherapy patients requires a deeper understanding at the cellular level, along with other advanced technologies. With this goal, this review summarises the current research of head and neck cancer CTC, CCSC and the molecular targets for personalised radiotherapy response.

Radiosensitivity prediction in head and neck cancer: selection of tumour cells and determination of chromosome aberrations

1999 ◽  
Vol 24 (4) ◽  
pp. 377-383
Author(s):  
J. M. coco martin ◽  
A. J. M. balm ◽  
E. mooren ◽  
D. sprong ◽  
H. bartelink ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Chromosome Aberrations ◽  
Tumour Cells ◽  
Selection Of
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