scholarly journals Integrating microRNA and mRNA expression profiles of acute promyelocytic leukemia cells to explore the occurrence mechanisms of differentiation syndrome

Oncotarget ◽  
2016 ◽  
Vol 7 (45) ◽  
pp. 73509-73524 ◽  
Author(s):  
Yingmei Zhang ◽  
Jinxiao Hou ◽  
Fei Ge ◽  
Fenglin Cao ◽  
Haitao Li ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Acute Promyelocytic Leukemia ◽  
Expression Profiles ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells

scholarly journals Expression Profiling of Murine Acute Promyelocytic Leukemia Cells Reveals Multiple Model-Dependent Progression Signatures

2004 ◽  
Vol 24 (24) ◽  
pp. 10882-10893 ◽  
Author(s):  
Matthew J. Walter ◽  
John S. Park ◽  
Steven K. M. Lau ◽  
Xia Li ◽  
Andrew A. Lane ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Promyelocytic Leukemia ◽  
Fusion Gene ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Promyelocytic Leukemia ◽  
Model Systems ◽  
Leukemia Cells ◽  
Molecular Signatures ◽  
Multiple Model

ABSTRACT Leukemia results from the expansion of self-renewing hematopoietic cells that are thought to contain mutations that contribute to disease initiation and progression. Studies of the gene expression profiles of human acute myeloid leukemia samples has allowed their classification based on the presence of translocations and French-American-British subtypes, but it is not yet clear whether their molecular signatures reflect the initiating mutations or mutations acquired during progression. To begin to address this question, we examined the expression profiles of normal murine promyelocyte-enriched samples, nontransformed murine promyelocytes expressing human promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) fusion gene, and primary acute promyelocytic leukemia cells. The expression profile of nontransformed cells expressing PML-RARα was remarkably similar to that of wild-type promyelocytes. In contrast, the expression profiles of fully transformed cells from three acute promyelocytic leukemia model systems were all different, suggesting that the expression signature of acute promyelocytic leukemia cells reflects the genetic changes that contributed to progression. To further evaluate these progression events, we compared two high-penetrance acute promyelocytic leukemia models that both commonly acquire an interstitial deletion of chromosome 2 during progression. The two models exhibited distinct gene expression profiles, suggesting that the dominant molecular signatures of murine acute promyelocytic leukemia can be influenced by several independent progression events.

scholarly journals Erratum: Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells

Leukemia ◽  
2005 ◽  
Vol 19 (2) ◽  
pp. 322-322
Author(s):  
P Lunghi ◽  
A Tabilio ◽  
F Lo-Coco ◽  
P Pelicci ◽  
A Bonati
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells

Metabolism of Arsenic Trioxide in Acute Promyelocytic Leukemia Cells

2014 ◽  
Vol 115 (10) ◽  
pp. 1729-1739 ◽  
Author(s):  
Ali Khaleghian ◽  
Seyed H. Ghaffari ◽  
Shahin Ahmadian ◽  
Kamran Alimoghaddam ◽  
Ardeshir Ghavamzadeh
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells

Regulatory mechanism and functional analysis of S100A9 in acute promyelocytic leukemia cells

2017 ◽  
Vol 11 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Yonglan Zhu ◽  
Fang Zhang ◽  
Shanzhen Zhang ◽  
Wanglong Deng ◽  
Huiyong Fan ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Acute Promyelocytic Leukemia ◽  
Regulatory Mechanism ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells
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