scholarly journals Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis

Oncotarget ◽  
2016 ◽  
Vol 7 (40) ◽  
pp. 65348-65363 ◽  
Author(s):  
Devika Kir ◽  
Manju Saluja ◽  
Shrey Modi ◽  
Annapoorna Venkatachalam ◽  
Erica Schnettler ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumor Angiogenesis ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Permeable Iron

scholarly journals Harmine suppresses bladder tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Cai Hai-rong ◽  
Huang Xiang ◽  
Zhang Xiao-rong
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Bladder Cancer ◽  
Growth Factor ◽  
Natural Product ◽  
Tumor Angiogenesis ◽  
Bladder Tumor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Human Bladder ◽  
Endothelial Growth Factor

Abstract Angiogenesis is a vital step during the process of oncogenesis of a lot of tumors, with no exception in bladder cancer. One of the useful strategies for the development of new drugs against cancer is targeting angiogenesis. In the present study, we found that a small-molecule natural product, which belonged to the β-carboline alkaloid, named harmine, could strongly inhibit tumor angiogenesis thus exhibiting its ideal treatment efficacy in bladder cancer. In vivo study verified that harmine had the effect of inhibition on human bladder tumor xenograft growth. The inhibitory effect of harmine to bladder cancer growth was coordinated by the effects shown on angiogenesis. To further explore the pharmacological activities of harmine, we tested harmine’s influence on blood vessel formation and found that harmine effectively blocked the microvessel sprouting in rat aortic ring assay when stimulated by vascular endothelial growth factor (VEGF). Furthermore, harmine inhibited human umbilical vein endothelial cell (HUVEC) proliferation as well as chemotactic motility, and when we treated HUVEC cell with harmine, the formation of capillary-like structures was also restrained. Moreover, harmine induced bladder cancer cell apoptosis through triggering the caspase-dependent apoptotic pathway and the downstream vascular endothelial growth factor receptor 2 (VEGFR2) kinase pathway was down-regulated, thus suppressing tumor development signals. Herein, our study demonstrated that natural product harmine might have potential in curing human bladder tumor because of its pharmacological function on tumor angiogenesis, trigged by VEGFR2 signaling pathways.

Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors

MedChemComm ◽  
2015 ◽  
Vol 6 (7) ◽  
pp. 1375-1380 ◽  
Author(s):  
Yongcong Lv ◽  
Mengyuan Li ◽  
Sufen Cao ◽  
Linjiang Tong ◽  
Ting Peng ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Tumor Angiogenesis ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive strategy for the treatment of cancer.

scholarly journals Microultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 in a Mouse Model of Tumor Angiogenesis

2007 ◽  
Vol 6 (5) ◽  
pp. 7290.2007.00024 ◽  
Author(s):  
Joshua J. Rychak ◽  
James Graba ◽  
Alison M.Y. Cheung ◽  
Bina S. Mystry ◽  
Jonathan R. Lindner ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumor Angiogenesis ◽  
High Frequency ◽  
Growth Factor Receptor ◽  
Ultrasound Contrast Agents ◽  
Center Frequency ◽  
Vascular Endothelial ◽  
Targeted Microbubbles ◽  
Endothelial Growth Factor

High-frequency microultrasound imaging of tumor progression in mice enables noninvasive anatomic and functional imaging at excellent spatial and temporal resolution, although microultrasonography alone does not offer molecular scale data. In the current study, we investigated the use of microbubble ultrasound contrast agents bearing targeting ligands specific for molecular markers of tumor angiogenesis using high-frequency microultrasound imaging. A xenograft tumor model in the mouse was used to image vascular endothelial growth factor receptor 2 (VEGFR-2) expression with microbubbles conjugated to an anti-VEGFR-2 monoclonal antibody or an isotype control. Microultrasound imaging was accomplished at a center frequency of 40 MHz, which provided lateral and axial resolutions of 40 and 90 μm, respectively. The B-mode (two-dimensional mode) acoustic signal from microbubbles bound to the molecular target was determined by an ultrasound-based destruction-subtraction scheme. Quantification of the adherent microbubble fraction in nine tumor-bearing mice revealed significant retention of VEGFR-2-targeted microbubbles relative to control-targeted microbubbles. These data demonstrate that contrast-enhanced microultrasound imaging is a useful method for assessing molecular expression of tumor angiogenesis in mice at high resolution.

scholarly journals A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

Cell Reports ◽  
2019 ◽  
Vol 28 (4) ◽  
pp. 949-965.e7 ◽  
Author(s):  
Kizito Njah ◽  
Sayan Chakraborty ◽  
Beiying Qiu ◽  
Surender Arumugam ◽  
Anandhkumar Raju ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumor Angiogenesis ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
The Stability ◽  
Endothelial Growth Factor
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