scholarly journals Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

Oncotarget ◽  
2016 ◽  
Vol 7 (35) ◽  
pp. 56030-56044 ◽  
Author(s):  
Jinwei Pang ◽  
Yue Wu ◽  
Jianhua Peng ◽  
Ping Yang ◽  
Li Kuai ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Apolipoprotein E ◽  
Blood Brain Barrier ◽  
Early Brain Injury ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Experimental Subarachnoid Hemorrhage ◽  
Blood Brain Barrier Integrity

scholarly journals COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Yongfa Zhang ◽  
Baocheng Gao ◽  
Jingsong Ouyang ◽  
Bai Tai ◽  
Shuai Zhou
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Early Brain Injury ◽  
Brain Barrier ◽  
Inflammasome Activation ◽  
Mimetic Peptide ◽  
Blood Brain ◽  
Experimental Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a kind of severe hemorrhagic stroke, and early brain injury acted as one of the main causes of death and delayed neurological deficit in patients with subarachnoid hemorrhage. In this process, the function and structural integrity of the blood-brain barrier play an important role. In this study, we have observed whether the apolipoprotein E (apoE) mimetic peptide, COG133, can alleviate early brain injury after subarachnoid hemorrhage. For this purpose, an experimental subarachnoid hemorrhage model was constructed in mice and treated by intravenous injection of COG133 at a dosage of 1 mg/kg. Then, the function and integrity of the blood-brain barrier were detected, and the pyroptosis level of the neuron was determined. The results showed that COG133 could protect blood-brain barrier function and structure integrity, reduce early brain injury, and ameliorate neurological function after subarachnoid hemorrhage. In terms of molecular mechanism, COG133 inhibits blood-brain barrier destruction through the proinflammatory CypA-NF-κB-MMP9 pathway and reduces neuronal pyroptosis by inhibiting NLRP3 inflammasome activation. In conclusion, this study demonstrated that apoE-mimetic peptide, COG133, can play a neuroprotective role by protecting blood-brain barrier function and inhibiting brain cell pyroptosis to reduce early brain injury after subarachnoid hemorrhage.

scholarly journals Cystatin C improves blood–brain barrier integrity after ischemic brain injury in mice

2019 ◽  
Vol 153 (3) ◽  
pp. 413-425 ◽  
Author(s):  
Bo Yang ◽  
Junjie Xu ◽  
Liuhui Chang ◽  
Zhigang Miao ◽  
Dara Heang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Blood Brain Barrier ◽  
Cystatin C ◽  
Brain Barrier ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

scholarly journals Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury

2014 ◽  
Vol 52 (3) ◽  
pp. 1119-1134 ◽  
Author(s):  
Brandon P. Lucke-Wold ◽  
Aric F. Logsdon ◽  
Kelly E. Smith ◽  
Ryan C. Turner ◽  
Daniel L. Alkon ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Bryostatin 1 ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity
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