scholarly journals Negative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (44) ◽  
pp. 72290-72299
Author(s):  
Qingguo Li ◽  
Lei Liang ◽  
Huixun Jia ◽  
Xinxiang Li ◽  
Ye Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Positive Lymph Node ◽  
Stage Iii ◽  
Lymph Node Status ◽  
Node Status ◽  
Node Ratio

The Impact of the Lymph Node Ratio is Greater than Traditional Lymph Node Status in Stage III Colorectal Cancer Patients

2013 ◽  
Vol 37 (8) ◽  
pp. 1927-1933 ◽  
Author(s):  
Yen-Jung Lu ◽  
Pei-Ching Lin ◽  
Chun-Chi Lin ◽  
Huann-Sheng Wang ◽  
Shung-Haur Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Lymph Node Status ◽  
Node Status ◽  
Node Ratio ◽  
Colorectal Cancer Patients ◽  
The Impact

scholarly journals Prognostic value of the lymph node ratio in stage III colorectal cancer

2012 ◽  
Vol 31 (5) ◽  
pp. 241-247 ◽  
Author(s):  
Jing-Qing Ren ◽  
Jian-Wei Liu ◽  
Zhi-Tang Chen ◽  
Shao-Jie Liu ◽  
Shi-Jie Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Node Ratio

Lymph node ratio as an independent prognostic indicator in stage III colorectal cancer: especially for fewer than 12 lymph nodes examined

Tumor Biology ◽  
2014 ◽  
Vol 35 (11) ◽  
pp. 11685-11690 ◽  
Author(s):  
Kewei Jiang ◽  
Yi Zhu ◽  
Yan Liu ◽  
Yingjiang Ye ◽  
Qiwei Xie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Prognostic Indicator ◽  
Stage Iii ◽  
Node Ratio

Vascular emboli as a prognostic factor in patients with stage III colorectal cancer undergoing radical surgery.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 570-570
Author(s):  
Haiping Pei ◽  
Qian Pei ◽  
Hong Zhu ◽  
Fengbo Tan
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Radical Surgery ◽  
Disease Free Survival ◽  
Stage Iii ◽  
Lymph Node Status ◽  
Node Status ◽  
Therapy Strategy

570 Background: The significance of vascular emboli (VE) in stage III colorectal cancer (CRC), the mechanism of their formation and their therapy strategy remain obscure demanding enhanced research. Methods: Data from 323 consecutive patients (192 non-VE, 131 VE) receiving radical surgery and adjuvant chemotherapy in our institution between Jan. 2009 and Nov. 2014 were retrospectively collected. The follow-up deadline was Feb. 2016. Potential prognostic risk factors were tested using univariate and multivariate survival analyses. mRNAs differentially expressed between VE and non-VE stage III CRC were analyzed using Agilent Gene Expression oligo-microarrays (Version 6.5). Patient-derived xenograft (PDX) nude mouse models were constructed to evaluate the efficacy of adjuvant chemotherapy plus targeted drugs (cetuximab or bevacizumab) on VE and non-VE stage III CRC. Results: VE was significantly associated with gross tumor morphology (p = 0.001), histologic type (p < 0.001), lymph node status (p < 0.001), sub-class of stage III (p =0.001), and serum CA199 level (p = 0.022). VE and lymph node status were independent risk factors for overall survival (OS) (p < 0.001, p = 0.008) and disease-free survival (DFS) (p < 0.001, p = 0.007). The median OS and DFS in VE stage III CRC patients were 38 months and 24 months, respectively. Compared with pericarcinous tissue, 809 genes (396 up-, 413 down-regulated) were differently expressed in no-VE tissue, and 1513 genes (898 up-, 615 down-regulated) in VE tissue. The top ten up-regulated protein-coding genes in VE stage III CRC were ITGBL1 (p<0.001), PROCR (p<0.001), CENPW (p<0.001), ZNF485 (p<0.001), VEGFA (p<0.001), DSG3 (p<0.001), CYP24A1 (p=0.001), COL10A1 (p=0.001), HIST3H2A (p=0.001)and PSAT1 (p=0.002). Conclusions: VE appears to be an independent risk factor for the prognosis of stage III CRC patients treated with radical surgery and adjuvant chemotherapy. Differently regulated genes seem to be involved in the formation and progress of VE. The therapy scheme should be more individualized taking into account the VE status.

Comparison of positive lymph node ratio with an inflammation-based prognostic score in colorectal cancer

2010 ◽  
Vol 98 (2) ◽  
pp. 282-286 ◽  
Author(s):  
S. J. Moug ◽  
G. McColl ◽  
S. M. Lloyd ◽  
G. Wilson ◽  
J. D. Saldanha ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Prognostic Score ◽  
Positive Lymph Node ◽  
Node Ratio

scholarly journals Clinical Significance of Lymph Node Ratio in Stage III Colorectal Cancer

2011 ◽  
Vol 27 (5) ◽  
pp. 260 ◽  
Author(s):  
Yo Han Park ◽  
Jae Im Lee ◽  
Jong Kyung Park ◽  
Hang Ju Jo ◽  
Won Kyung Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Clinical Significance ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Node Ratio

scholarly journals Clinical impact of molecular positive lymph node status in colorectal cancer

2017 ◽  
Vol 28 ◽  
pp. v190
Author(s):  
N. Matsuura ◽  
N. Tomita ◽  
M. Inomata ◽  
K. Murata ◽  
S. Hayashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Positive Lymph Node ◽  
Clinical Impact ◽  
Lymph Node Status ◽  
Node Status ◽  
Positive Lymph Node Status

Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer

Surgery Today ◽  
2011 ◽  
Vol 41 (10) ◽  
pp. 1370-1379 ◽  
Author(s):  
Manabu Shimomura ◽  
Satoshi Ikeda ◽  
Yuji Takakura ◽  
Yasuo Kawaguchi ◽  
Masakazu Tokunaga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Node Ratio ◽  
Lymph Node Examination ◽  
Adequate Lymph Node

Prognostic value of lymph node ratio in stage III colorectal cancer

2011 ◽  
Vol 13 (10) ◽  
pp. 1116-1122 ◽  
Author(s):  
K. P. Wong ◽  
J. T. C. Poon ◽  
J. K. M. Fan ◽  
W. L. Law
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Node Ratio
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