scholarly journals An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (35) ◽  
pp. 56758-56766 ◽  
Author(s):  
Bing-Li Wu ◽  
Dong Wang ◽  
Wen-Jing Bai ◽  
Fan Zhang ◽  
Xing Zhao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Integrative Framework

The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma

Esophagus ◽  
2018 ◽  
Vol 15 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Yasunori Akutsu ◽  
Kentaro Murakami ◽  
Masayuki Kano ◽  
Takeshi Toyozumi ◽  
Yasunori Matsumoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Peripheral Blood

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

2012 ◽  
Vol 72 (16) ◽  
pp. 3967-3976 ◽  
Author(s):  
Yoshiyuki Suzuki ◽  
Kousaku Mimura ◽  
Yuya Yoshimoto ◽  
Mitsuaki Watanabe ◽  
Yu Ohkubo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Cell Death ◽  
Immunogenic Tumor ◽  
Immunogenic Tumor Cell

scholarly journals The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21542-21555 ◽  
Author(s):  
Wei Li ◽  
Guixue Hou ◽  
Dianrong Zhou ◽  
Xiaomin Lou ◽  
Yang Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Squamous Cell Carcinoma Cell

scholarly journals Programmed cell death ligand 1 expression in esophageal squamous cell carcinoma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lei Guo ◽  
Ying Ji ◽  
Wei Guo ◽  
Peng Song ◽  
Xue-Min Xue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis

2020 ◽  
Vol 28 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Huasong Liu ◽  
Jun Zhang ◽  
Xiangyu Luo ◽  
Min Zeng ◽  
Liqiang Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cisplatin Resistance ◽  
Vitro Assay ◽  
The Impact ◽  
Stimulation Of

Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) mediate the development of esophageal squamous cell carcinoma (ESCC) via various pathophysiological pathways. This study explored the impact of the lncRNA FOXD2-AS1 on cisplatin resistance in ESCC and its possible mechanisms. Upregulation of FOXD2-AS was detected in patients with ESCC and ESCC cells that are resistant to cisplatin. In an in vitro assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and repressed the stimulation of the Akt/mTOR axis in cisplatin-resistant ESCC cells (TE-1/DDP). Conversely, the overexpression of FOXD2-AS1 remarkably increased cell invasion and growth, repressed cell death, and triggered the stimulation of the Akt/mTOR axis in TE-1/DDP cells. These findings, along with bioinformatics and validation tests, showed that FOXD2-AS1 targeted miR-195 by acting as a competing endogenous RNA. FOXD2-AS1/miR-195/Akt/mTOR axis plays a crucial role in resistance to cisplatin in ESCC cells, offering an innovative strategy to treat ESCC.

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