scholarly journals Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells

Oncotarget ◽  
2016 ◽  
Vol 8 (23) ◽  
pp. 37009-37022 ◽  
Author(s):  
Bernd A. Czulkies ◽  
Justin Mastroianni ◽  
Lisa Lutz ◽  
Sarah Lang ◽  
Carsten Schwan ◽  
...  
Keyword(s):  
Tumor Xenograft ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

scholarly journals Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma

2020 ◽  
Vol 40 (15) ◽  
Author(s):  
Dingyang Li ◽  
Zhe Tang ◽  
Zhiqiang Gao ◽  
Pengcheng Shen ◽  
Zhaochen Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Target Genes ◽  
Circular Rna ◽  
Tumor Xenograft ◽  
Mrna Levels ◽  
Cell Behaviors ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

ABSTRACT It has been found that the circular RNA (circRNA) CDR1as is upregulated in cholangiocarcinoma (CCA) tissues. In this study, we tried to explore the roles of CDR1as in CCA. CDR1as was overexpressed or knocked down in human CCA cells to assess the effects of CDR1as on cell behaviors and tumor xenograft growth. In vitro, the CDR1as level was significantly increased in CCA cell lines. The results showed that CDR1as promoted the cell proliferation, migration, invasion, and activation of the AKT3/mTOR pathway in CCA cells. Moreover, miR-641, a predicted target microRNA (miRNA) of CDR1as, could partially reverse the effects of CDR1as on cell behaviors in CCA cells. Furthermore, CDR1as improved tumor xenograft growth, and it could be attenuated by miR-641 in vivo. Additionally, CDR1as expression was inversely correlated with miR-641 in CCA cells, and miR-641 could directly bind with CDR1as and its target genes, the AKT3 and mTOR genes. Mechanistically, CDR1as could bind with miR-641 and accelerate miR-641 degradation, which possibly leads to the upregulation of the relative mRNA levels of AKT3 and mTOR in RBE cells. In conclusion, our findings indicated that CDR1as might exert oncogenic properties, at least partially, by regulating miR-641 in CCA. CDR1as and miR-641 could be considered therapeutic targets for CCA.

scholarly journals AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

2007 ◽  
Vol 13 (12) ◽  
pp. 3682-3688 ◽  
Author(s):  
Robert W. Wilkinson ◽  
Rajesh Odedra ◽  
Simon P. Heaton ◽  
Stephen R. Wedge ◽  
Nicholas J. Keen ◽  
...  
Keyword(s):  
Human Tumor ◽  
Selective Inhibitor ◽  
Tumor Xenograft ◽  
Aurora B ◽  
Human Tumor Xenograft ◽  
Aurora B Kinase ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

scholarly journals Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

2013 ◽  
Vol 12 (8) ◽  
pp. 1453-1460 ◽  
Author(s):  
K. Mark Parnell ◽  
Jason M. Foulks ◽  
Rebecca N. Nix ◽  
Adrianne Clifford ◽  
Jeremy Bullough ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Tumor Xenograft ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

scholarly journals Neutralization of Adrenomedullin Inhibits the Growth of Human Glioblastoma Cell Lines in Vitro and Suppresses Tumor Xenograft Growth in Vivo

2002 ◽  
Vol 160 (4) ◽  
pp. 1279-1292 ◽  
Author(s):  
L'Houcine Ouafik ◽  
Samantha Sauze ◽  
Françoise Boudouresque ◽  
Olivier Chinot ◽  
Christine Delfino ◽  
...  
Keyword(s):  
Cell Lines ◽  
Tumor Xenograft ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth ◽  
Glioblastoma Cell Lines

241 Small Molecule Inhibitors Xmd8-92 and Pv1019 Inhibit Pancreatic Tumor Xenograft Growth via a DCLK1 Dependent Mechanism

2013 ◽  
Vol 144 (5) ◽  
pp. S-53
Author(s):  
Sripathi M. Sureban ◽  
Dongfeng Qu ◽  
Parthasarathy Chandrakesan ◽  
Randal May ◽  
Nathaniel Weygant ◽  
...  
Keyword(s):  
Small Molecule ◽  
Pancreatic Tumor ◽  
Small Molecule Inhibitors ◽  
Tumor Xenograft ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth ◽  
Dependent Mechanism

225 THE EFFECTS OF CHOLESTEROL TREATMENT DRUGS ALONE AND IN COMBINATION ON PROSTATE TUMOR XENOGRAFT GROWTH

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Elizabeth M. Masko ◽  
Keith R. Solomon ◽  
Nikolaos A. Valilis ◽  
Alexis R. Gaines ◽  
Michael J. Muehlbauer ◽  
...  
Keyword(s):  
Prostate Tumor ◽  
Tumor Xenograft ◽  
Xenograft Growth ◽  
Cholesterol Treatment ◽  
Tumor Xenograft Growth
Sign in / Sign up

Export Citation Format

Share Document