scholarly journals Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47494-47510 ◽  
Author(s):  
Chengqian Yin ◽  
Dan He ◽  
Shuyang Chen ◽  
Xiaoling Tan ◽  
Nianli Sang
Keyword(s):  
Cancer Cell ◽  
Adaptation To Hypoxia ◽  
Cell Adaptation

scholarly journals Cyclic 3′,5′-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia

Cancer ◽  
2011 ◽  
Vol 117 (23) ◽  
pp. 5282-5293 ◽  
Author(s):  
In-Kiu Kwon ◽  
Rui Wang ◽  
Nikhil Prakash ◽  
Renee Bozard ◽  
Troy A. Baudino ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Guanosine Monophosphate ◽  
Adaptation To Hypoxia ◽  
Dependent Protein Kinase ◽  
Cell Adaptation ◽  
Dependent Protein

scholarly journals Author response: Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

2017 ◽  
Author(s):  
Xiaodong Zhang ◽  
Alicia M Saarinen ◽  
Taro Hitosugi ◽  
Zhenghe Wang ◽  
Liguo Wang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Response Inhibition ◽  
Human Cancer ◽  
Author Response ◽  
Adaptation To Hypoxia ◽  
Human Cancer Cell ◽  
Cell Adaptation

scholarly journals Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

2018 ◽  
Vol 10 (11) ◽  
Author(s):  
Alexander Greenhough ◽  
Clare Bagley ◽  
Kate J Heesom ◽  
David B Gurevich ◽  
David Gay ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Adaptation To Hypoxia ◽  
Cell Adaptation

scholarly journals ERK signalling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1

2021 ◽  
Author(s):  
Kreon Koukoulas ◽  
Antonis Giakountis ◽  
Angeliki Karagiota ◽  
Martina Samiotaki ◽  
George Panayotou ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Adaptation To Hypoxia ◽  
Cell Adaptation

scholarly journals Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1102
Author(s):  
Alexander E. Kabakov ◽  
Anna O. Yakimova
Keyword(s):  
Heat Shock ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Liver Tumors ◽  
Oxygen Deficiency ◽  
Transarterial Embolization ◽  
Antiangiogenic Therapy ◽  
Adaptation To Hypoxia ◽  
Mesenchymal Transition

Within aggressive malignancies, there usually are the “hypoxic zones”—poorly vascularized regions where tumor cells undergo oxygen deficiency through inadequate blood supply. Besides, hypoxia may arise in tumors as a result of antiangiogenic therapy or transarterial embolization. Adapting to hypoxia, tumor cells acquire a hypoxia-resistant phenotype with the characteristic alterations in signaling, gene expression and metabolism. Both the lack of oxygen by itself and the hypoxia-responsive phenotypic modulations render tumor cells more radioresistant, so that hypoxic tumors are a serious challenge for radiotherapy. An understanding of causes of the radioresistance of hypoxic tumors would help to develop novel ways for overcoming this challenge. Molecular targets for and various approaches to radiosensitizing hypoxic tumors are considered in the present review. It is here analyzed how the hypoxia-induced cellular responses involving hypoxia-inducible factor-1, heat shock transcription factor 1, heat shock proteins, glucose-regulated proteins, epigenetic regulators, autophagy, energy metabolism reprogramming, epithelial–mesenchymal transition and exosome generation contribute to the radioresistance of hypoxic tumors or may be inhibited for attenuating this radioresistance. The pretreatments with a multitarget inhibition of the cancer cell adaptation to hypoxia seem to be a promising approach to sensitizing hypoxic carcinomas, gliomas, lymphomas, sarcomas to radiotherapy and, also, liver tumors to radioembolization.

scholarly journals The mitochondrial ATP-dependent potassium channel and its pharmacological modulators

2016 ◽  
Vol 14 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Elena V Pogilova ◽  
Vasiliy E Novikov ◽  
Olga S Levchenkova
Keyword(s):  
Potassium Channel ◽  
The State ◽  
Adaptation To Hypoxia ◽  
Metabolic Processes ◽  
Cell Adaptation ◽  
Pharmacological Modulation ◽  
Pharmacological Modulators

This review is devoted to analysis of current research about the role of mitochondrial ATP-dependent potassium channel (mitoКАТP) in the regulation of metabolic processes of the cell. The mechanisms of cell adaptation to hypoxia and ischemia involving mitoКАТP is considered in the article. The opportunity of pharmacological modulation of mitoКАТP activity to stimulate processes of cell adaptation to damaging factors is discussed. This approach seems promising for the development of effective pharmacotherapy of diseases which have in their pathogenesis the state of hypoxia and ischemia.

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