scholarly journals Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39332-39344 ◽  
Author(s):  
Jianmei Yang ◽  
Xiaoming Zhou ◽  
Xu Zhang ◽  
Jianting Hu ◽  
Ling Gao ◽  
...  
Keyword(s):  
Male Rats ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

Evaluation of hypothalamus-pituitary-thyroid axis function by chronic perchlorate exposure in male rats

2017 ◽  
Vol 33 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Caroline Serrano-Nascimento ◽  
Jamile Calil-Silveira ◽  
Rafael Dalbosco ◽  
Telma Tenorio Zorn ◽  
Maria Tereza Nunes
Keyword(s):  
Male Rats ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

Plasma neurotensin levels in humans: relation to hormone levels in diseases involving the hypothalamo-pituitary-thyroid axis

1995 ◽  
Vol 133 (5) ◽  
pp. 534-538 ◽  
Author(s):  
Rose-Marie Schimpff ◽  
Micheline Gourmelen ◽  
Valérie Scarcériaux ◽  
Anne-Marie Lhiaubet ◽  
William Rostène
Keyword(s):  
Healthy Adults ◽  
Thyroid Status ◽  
Central Hypothyroidism ◽  
Mean Values ◽  
Hormone Levels ◽  
Percentage Decrease ◽  
Pituitary Thyroid Axis ◽  
Endocrine Status ◽  
Thyroid Axis ◽  
Adult Volunteers

Schimpff R-M, Gourmelen M, Scarcériaux V, Lhiaubet A-M, Rostène W. Plasma neurotensin levels in humans: relation to hormone levels in diseases involving the hypothalamo-pituitary-thyroid axis. Eur J Endocrinol 1995;133:534–8. ISSN 0804–4643 This study was aimed to investigate, in humans, the possible relationship between plasma neurotensin (NT) levels and the activity of the hypothalamo-pituitary-thyroid axis. Neurotensin was measured by radioimmunoassay in 14 healthy adult volunteers and in 41 patients among whom 10 were considered as controls and 31 had thyroid dysfunction according to free thyroxine and thyrotropin plasma values. Basal NT levels were not significantly different in healthy adults and in control patients: 9.7 ± 1.1 fmol/ml (mean±sem) vs 13.3 ± 2.9fmol/ml, respectively. In patients with central hypothyroidism the NT level was significantly lower (5.7 ± 1.2 vs healthy volunteers and controls; p < 0.05) and in patients with peripheral hypothyroidism and hyperthyroidism the NT level was significantly higher (35.9 ± 12.8 and 29.9 ± 9.5 fmol/ml, respectively, vs healthy adults (p < 0.01) and vs controls (p < 0.05)). After thyrotropin-releasing hormone (TRH) injection (250 μg iv) in nine subjects (two control patients, five patients with hypothyroidism and two patients with hyperthyroidism), NT levels decreased independently of the endocrine status from mean values of 13.4 ± 8.4 at basal level to 7.3 ± 0.8 fmol/ml 30 min after injection (p < 0.01 on paired percentage decrease values). These data suggest that plasma NT levels in humans depend upon the pituitary-thyroid status and indicate that TRH could exert a negative regulation on circulating NT levels. R-M Schimpff, INSERM U 339. Hôpital St Antoine, 184 rue du Faubourg, St Antoine, Paris 75012, France

scholarly journals Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126

2007 ◽  
Vol 97 (2) ◽  
pp. 308-317 ◽  
Author(s):  
Eva D. McLanahan ◽  
Jerry L. Campbell ◽  
Duncan C. Ferguson ◽  
Barry Harmon ◽  
Joan M. Hedge ◽  
...  
Keyword(s):  
Ammonium Perchlorate ◽  
Adult Male ◽  
Low Dose ◽  
Male Rats ◽  
Dose Effects ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Low Dose Effects

scholarly journals Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Taha O. Mahwi ◽  
Darya S. Abdulateef
Keyword(s):  
Sunshine Duration ◽  
Winter Season ◽  
Extreme Temperature ◽  
Temperate Climate ◽  
Human Pituitary ◽  
Positive Correlation ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Different Seasons ◽  
Thyroid Axis

Background. Various changes in thyroid hormones (TH) and thyroid-stimulating hormone (TSH) level were observed in different seasons among euthyroid and hypothyroid subjects living in areas with an extreme temperature difference between summer and winter.Objectives. This study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH.Method.In a prospective study on 152 healthy (euthyroid) volunteers and 25 SCH subjects, the serum hormone levels (TSH, FT4, and FT3) were measured in both the summer and winter seasons and correlated with all the climate components using Pearson’s correlation coefficient. The effect of duration of outdoor exposure on hormone levels was compared using a paired samplet-test (P<0.05).Results. Small but statistically significant increased FT3 level and decreased FT4 level were observed during the winter season in euthyroid and SCH subjects, respectively. There was a significant negative correlation between FT3 and FT3/FT4 ratio with temperature and sunshine duration and a positive correlation with humidity and atmospheric pressure. A positive correlation was found between FT4 and sunshine duration.Conclusion. The climate components contributed to the slight variance in hormone levels in different seasons, and the effect was mostly on peripheral conversion of FT4 to FT3 rather than the pituitary-thyroid axis leading to slightly higher FT3 in winter. Seasonal variation does not affect the diagnosis of SCH cases.

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