scholarly journals Telomere length is maternally inherited and associated with lipid metabolism in Chinese population

Aging ◽  
2022 ◽  
Author(s):  
Liyun Guo ◽  
Yajuan Chen ◽  
Huiqin Li ◽  
Fanqian Yin ◽  
Mingxia Ge ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Telomere Length ◽  
Chinese Population

Telomere length, genetic variants and gastric cancer risk in a Chinese population

2015 ◽  
Vol 36 (9) ◽  
pp. 963-970 ◽  
Author(s):  
Jiangbo Du ◽  
Xun Zhu ◽  
Cuiwei Xie ◽  
Ningbin Dai ◽  
Yayun Gu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Genetic Variants ◽  
Chinese Population ◽  
Gastric Cancer Risk

The visfatin gene is associated with glucose and lipid metabolism in a Chinese population

2006 ◽  
Vol 23 (9) ◽  
pp. 967-973 ◽  
Author(s):  
W.-X. Jian ◽  
T.-H. Luo ◽  
Y.-Y. Gu ◽  
H.-L. Zhang ◽  
S. Zheng ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Chinese Population ◽  
Glucose And Lipid Metabolism

scholarly journals Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Rajkumar Dorajoo ◽  
Xuling Chang ◽  
Resham Lal Gurung ◽  
Zheng Li ◽  
Ling Wang ◽  
...  
Keyword(s):  
Telomere Length ◽  
Chinese Population ◽  
Human Leukocyte ◽  
Leukocyte Telomere Length ◽  
Genetic Studies

scholarly journals Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Xuling Chang ◽  
Rajkumar Dorajoo ◽  
Ye Sun ◽  
Ling Wang ◽  
Choon Nam Ong ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Telomere Length ◽  
Polyunsaturated Fatty Acid ◽  
Genetic Variants ◽  
Chinese Population ◽  
Equation Modeling ◽  
Independent Effect ◽  
Total N ◽  
Pufa Ratio ◽  
Cad Risk

Abstract Background Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of telomere is a marker of accelerated aging and can be influenced by oxidative stress and nutritional deficiency. Plasma n6:n3 polyunsaturated fatty acid (PUFA) ratio may impact cell aging. Increased dietary intake of marine n-3 PUFA is associated with reduced telomere attrition. However, the effect of plasma PUFA on leukocyte telomere length (LTL) and its interaction with genetic variants are not well established. Methods A nested coronary artery disease (CAD) case-control study comprising 711 cases and 638 controls was conducted within the Singapore Chinese Health Study (SCHS). Samples genotyped with the Illumina ZhongHua-8 array. Plasma n-3 and n-6 PUFA were quantified using mass spectrometry (MS). LTL was measured with quantitative PCR method. Linear regression was used to test the association between PUFA and LTL. The interaction between plasma PUFAs and genetic variants was assessed by introducing an additional term (PUFA×genetic variant) in the regression model. Analysis was carried out in cases and controls separately and subsequently meta-analyzed using the inverse-variance weighted method. We further assessed the association of PUFA and LTL with CAD risk by Cox Proportional-Hazards model and whether the effect of PUFA on CAD was mediated through LTL by using structural equation modeling. Results Higher n6:n3 ratio was significantly associated with shorter LTL (p = 0.018) and increased CAD risk (p = 0.005). These associations were mainly driven by elevated plasma total n-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (p < 0.05). There was a statistically significant interaction for an intergenic single nucleotide polymorphism (SNP) rs529143 with plasma total n-3 PUFA and DHA on LTL beyond the genome-wide threshold (p < 5 ×  10− 8). Mediation analysis showed that PUFA and LTL affected CAD risk independently. Conclusions Higher plasma n6:n3 PUFA ratio, and lower EPA and DHA n-3 PUFAs were associated with shorter LTL and increased CAD risk in this Chinese population. Furthermore, genetic variants may modify the effect of PUFAs on LTL. PUFA and LTL had independent effect on CAD risk in our study population.

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