scholarly journals Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging

Aging ◽  
2021 ◽  
Author(s):  
Emanuel Barth ◽  
Akash Srivastava ◽  
Diane Wengerodt ◽  
Milan Stojiljkovic ◽  
Hubertus Axer ◽  
...  
Keyword(s):  
Circadian System ◽  
Age Dependent

scholarly journals Age-Dependent Effects of Conditioning on Cholinergic and Vasopressin Systems in the Rat Suprachiasmatic Nucleus

2003 ◽  
Vol 384 (5) ◽  
pp. 729-736 ◽  
Author(s):  
B. A. M. Biemans ◽  
E. A. Van der Zee ◽  
S. Daan
Keyword(s):  
Fear Conditioning ◽  
Suprachiasmatic Nucleus ◽  
Acetylcholine Receptors ◽  
Circadian System ◽  
Muscarinic Acetylcholine Receptors ◽  
Dependent Manner ◽  
Aged Rats ◽  
Muscarinic Acetylcholine ◽  
Young Rats ◽  
Age Dependent

Abstract Active shock avoidance was used to explore the impact of behavioural stimulation on the neurochemistry of the suprachiasmatic nucleus. We have found previously that the expression of muscarinic acetylcholine receptors in the suprachiasmatic nucleus of young rats was significantly enhanced 24 hours after fear conditioning. Here, we investigated whether this observation is age-dependent. We used 26 month-old Wistar rats with a deteriorated circadian system, and compared them with young rats (4 months of age) with an intact circadian system. Vasopressin, representing a major output system of the suprachiasmatic nucleus, was studied in addition to muscarinic receptors. Young rats showed a significant increase in immunostaining for muscarinic acetylcholine receptors 24 h after training, corroborating earlier observations. Aged rats did not show such an increase. In contrast, aged rats did show an increase in vasopressin immunoreactivity 24 h after fear conditioning, both at the level of content and cell number, while young rats did not reveal a significant rise. Thus, it seems that these two neurochemical systems in the suprachiasmatic nucleus are regulated independently. The results further demonstrate that the circadian pacemaker is influenced by fear conditioning in an age-dependent manner.

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

1248: Impact of Surgical Treatment of Renal Carcinoma on Renal Function and Blood Pressure: A Race- and Age-Dependent Association

2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Surgical Treatment ◽  
Renal Carcinoma ◽  
Age Dependent

Age-dependent differences in postoperative HLA-DR expression in cardiac surgery patients

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
K Lazouski ◽  
A Zittermann ◽  
M Schmidt ◽  
J Gummert ◽  
J Börgermann
Keyword(s):  
Cardiac Surgery ◽  
Hla Dr ◽  
Age Dependent
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