scholarly journals LncRNA SNHG17 promotes tumor progression and predicts poor survival in human renal cell carcinoma via sponging miR-328-3p

Aging ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 21232-21250
Author(s):  
Jie Wu ◽  
Gang Dong ◽  
Tingting Liu ◽  
Shaojin Zhang ◽  
Lulu Sun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Survival ◽  
Human Renal Cell Carcinoma

Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma

2000 ◽  
Vol 91 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Lorenzo Lusini ◽  
Sergio Antonio Tripodi ◽  
Ranieri Rossi ◽  
Fabiola Giannerini ◽  
Daniela Giustarini ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma ◽  
Anti Oxidant

Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma

2021 ◽  
pp. 1-8
Author(s):  
Qianfeng Zhuang ◽  
Min Fan ◽  
Jie Shen ◽  
Zhen Chen ◽  
Dong Xue ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Prognostic Marker ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Migration And Invasion ◽  
Human Renal Cell Carcinoma ◽  
Tumor Tissues

<b><i>Introduction:</i></b> Calpain small subunit 1 (Capns1) has shown its correlation with the metastasis and invasion of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. However, the expression and function of Capns1 in human renal cell carcinoma (RCC) have not been clarified. This study aimed to examine the expression of Capns1 in RCC tissues and cell lines and to assess its role performed in RCC. <b><i>Methods:</i></b> Capns1 expression was evaluated in 75 pairs of RCC and matched adjacent non-tumor tissues by immunohistochemistry. The prognostic value of Capns1 in RCC was assessed by Kaplan-Meier and Cox regression analyses. The action of Capns1 in the proliferation, adhesion, migration, and invasion of RCC cells and the effects on matrix metalloproteinase (MMP) 2 and 9 expression were evaluated after Capns1 silence. <b><i>Results:</i></b> Capns1 expression was significantly higher in RCC tissues compared with the adjacent non-tumor tissues. Multivariate analysis showed that Capns1 overexpression was an independent poor prognostic marker in RCC. The silencing of Capns1 prohibited cell adhesion and impaired the migration and invasion ability of 786-O cells in vitro. Furthermore, Capns1 silence reduced MMP2 and MMP9 expression. <b><i>Conclusion:</i></b> Capns1 overexpression predicts poor prognosis and correlates with tumor progression in RCC. Capns1 expression might serve a prognostic marker and therapeutic target for RCC.

1008: Expression of Cyclooxygenase-2 (COX-2) in Human Renal Cell Carcinoma (RCCA)

2004 ◽  
Vol 171 (4S) ◽  
pp. 266-267
Author(s):  
Sean McLaughlin ◽  
Eric Wallen ◽  
William K. Funkhouser ◽  
Raj S. Pruthi
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cyclooxygenase 2 ◽  
Human Renal Cell Carcinoma ◽  
Cox 2
Sign in / Sign up

Export Citation Format

Share Document