scholarly journals Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathway

Aging ◽  
2021 ◽  
Author(s):  
Jia Luo ◽  
Yigui Jiang ◽  
Lianhui Wu ◽  
Dexiang Zhuo ◽  
Shengjun Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Focal Adhesion ◽  
Akt Signaling ◽  
Integrin Subunit ◽  
Akt Signaling Pathway ◽  
Non Coding Rna ◽  
Colorectal Cancer Progression ◽  
Phosphoinositide 3 Kinase ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA AGER-1 inhibits colorectal cancer progression through sponging miR-182

2020 ◽  
Vol 35 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Mingzhu Lin ◽  
Yinyan Li ◽  
Jianfeng Xian ◽  
Jinbin Chen ◽  
Yingyi Feng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Ectopic Expression ◽  
Tumor Development ◽  
Vital Role ◽  
Normal Tissues ◽  
Non Coding Rna ◽  
Colorectal Cancer Progression ◽  
And Migration ◽  
Long Non Coding Rna

Objective: Abundant evidence has illustrated that long non-coding RNA (lncRNA) plays a vital role in the regulation of tumor development and progression. Ectopic expression of a novel lncRNA, termed lnc-AGER-1, has been discovered in cancers, and this lncRNA was reported to exert an anti-tumor effect. However, its biological mechanism remains unelucidated in colorectal cancer. Methods: A total of 159 paired colorectal cancer specimens and adjacent tissues was applied to detect the expression of lnc-AGER-1 by the quantitative Real-time PCR (qRT-PCR), and a series of functional assays was executed to uncover the role of this lncRNA on colorectal cancer. Results: We found that the expression of lnc-AGER-1 in the tumor tissues was significantly down-regulated, while compared with adjacent normal tissues (0.0115 ± 0.0718 vs. 0.0347 ± 0.157; P < 0.0001). Also, lnc-AGER-1 was observably associated with clinical T status (r = −0.184, P = 0.024). Patients with advanced T status exerted a significantly lower level of lnc-AGER-1 than those with early T status (20.0% vs. 40.7%, P = 0.021). Over-expression of lnc-AGER-1 inhibited cell proliferation and migration efficiency, and induced cell cycle arrest at the G0/G1 phase, and promoted cell apoptosis. Further research proved that lnc-AGER-1 altered the expression of its neighbor gene, AGER, through acting as a competing endogenous RNA for miR-182 in colorectal cancer. Conclusion: lnc-AGER-1 has a suppressive role in colorectal cancer development via modulating AGER, which may serve as a target for colorectal cancer diagnosis and treatment.

scholarly journals Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jessica M. Silva-Fisher ◽  
Ha X. Dang ◽  
Nicole M. White ◽  
Matthew S. Strand ◽  
Bradley A. Krasnick ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Progression ◽  
Non Coding Rna ◽  
Colorectal Cancer Progression ◽  
Long Non Coding Rna

scholarly journals The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Xue Wang ◽  
Hongfei Yu ◽  
Wenjie Sun ◽  
Jianlu Kong ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Non Coding Rna ◽  
Colorectal Cancer Progression ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA SNHG16 Activates USP22 Expression to Promote Colorectal Cancer Progression by Sponging miR-132-3p

2020 ◽  
Vol Volume 13 ◽  
pp. 4283-4294
Author(s):  
Xiaowen He ◽  
Jun Ma ◽  
Mingming Zhang ◽  
Jianhua Cui ◽  
Hao Yang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Non Coding Rna ◽  
Colorectal Cancer Progression ◽  
Long Non Coding Rna
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