scholarly journals The dual distinct role of telomerase in repression of senescence and myofibroblast differentiation

Aging ◽  
2021 ◽  
Author(s):  
Masanori Harada ◽  
Biao Hu ◽  
Jeffrey Lu ◽  
Jing Wang ◽  
Andrew E. Rinke ◽  
...  
Keyword(s):  
Myofibroblast Differentiation ◽  
Distinct Role

scholarly journals F4/80+ Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2231
Author(s):  
Qingjun Lu ◽  
Hao Shen ◽  
Han Yu ◽  
Jing Fu ◽  
Hui Dong ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Serum Levels ◽  
Inhibitory Effect ◽  
Regenerative Process ◽  
Oncostatin M ◽  
Hepatocyte Proliferation ◽  
Initiation Phase ◽  
Distinct Role

The role of Kupffer cells (KCs) in liver regeneration is complicated and controversial. To investigate the distinct role of F4/80+ KCs at the different stages of the regeneration process, two-thirds partial hepatectomy (PHx) was performed in mice to induce physiological liver regeneration. In pre- or post-PHx, the clearance of KCs by intraperitoneal injection of the anti-F4/80 antibody (α-F4/80) was performed to study the distinct role of F4/80+ KCs during the regenerative process. In RNA sequencing of isolated F4/80+ KCs, the initiation phase was compared with the progression phase. Immunohistochemistry and immunofluorescence staining of Ki67, HNF-4α, CD-31, and F4/80 and Western blot of the TGF-β2 pathway were performed. Depletion of F4/80+ KCs in pre-PHx delayed the peak of hepatocyte proliferation from 48 h to 120 h, whereas depletion in post-PHx unexpectedly led to persistent inhibition of hepatocyte proliferation, indicating the distinct role of F4/80+ KCs in the initiation and progression phases of liver regeneration. F4/80+ KC depletion in post-PHx could significantly increase TGF-β2 serum levels, while TGF-βRI partially rescued the impaired proliferation of hepatocytes. Additionally, F4/80+ KC depletion in post-PHx significantly lowered the expression of oncostatin M (OSM), a key downstream mediator of interleukin-6, which is required for hepatocyte proliferation during liver regeneration. In vivo, recombinant OSM (r-OSM) treatment alleviated the inhibitory effect of α-F4/80 on the regenerative progression. Collectively, F4/80+ KCs release OSM to inhibit TGF-β2 activation, sustaining hepatocyte proliferation by releasing a proliferative brake.

scholarly journals Distribution and function of carbamate hydrolase genes cehA and mcd in soils: the distinct role of soil pH

2018 ◽  
Vol 94 (6) ◽  
Author(s):  
Constantina Rousidou ◽  
Dionysis Karaiskos ◽  
Despoina Myti ◽  
Evangelos Karanasios ◽  
Panagiotis A Karas ◽  
...  
Keyword(s):  
Soil Ph ◽  
And Function ◽  
Distinct Role

scholarly journals Role of Cation Channel TRPV4 in Mechanosensing, Myofibroblast Differentiation, and Pulmonary Fibrosis

2015 ◽  
Vol 12 (Supplement 1) ◽  
pp. S74-S75
Author(s):  
Shaik O. Rahaman ◽  
Lisa M. Grove ◽  
Brian D. Southern ◽  
Rachel G. Scheraga ◽  
Susamma Abraham ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Cation Channel ◽  
Myofibroblast Differentiation

scholarly journals Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

2009 ◽  
Vol 41 (3) ◽  
pp. 332-338 ◽  
Author(s):  
Nathan Sandbo ◽  
Steven Kregel ◽  
Sebastien Taurin ◽  
Sangeeta Bhorade ◽  
Nickolai O. Dulin
Keyword(s):  
Serum Response Factor ◽  
Critical Role ◽  
Myofibroblast Differentiation ◽  
Response Factor ◽  
Serum Response

Distinct role of insulin and IGF-I and its receptors in white skeletal muscle during the compensatory growth of gilthead sea bream (Sparus aurata)

Aquaculture ◽  
2007 ◽  
Vol 267 (1-4) ◽  
pp. 188-198 ◽  
Author(s):  
Núria Montserrat ◽  
Pedro Gómez-Requeni ◽  
Giovanni Bellini ◽  
Encarnación Capilla ◽  
Jaume Pérez-Sánchez ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Compensatory Growth ◽  
Sparus Aurata ◽  
Gilthead Sea Bream ◽  
Sea Bream ◽  
Igf I ◽  
Distinct Role

Distinct role of adiposity and insulin resistance in glucose intolerance: Studies in ventromedial hypothalamic-lesioned obese rats

Metabolism ◽  
2002 ◽  
Vol 51 (6) ◽  
pp. 716-723 ◽  
Author(s):  
Asako Kageyama ◽  
Tsutomu Hirano ◽  
Haruaki Kageyama ◽  
Toshimasa Osaka ◽  
Yoshio Namba ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Obese Rats ◽  
Distinct Role

scholarly journals Evolutionary Algorithms for Boolean Functions in Diverse Domains of Cryptography

2016 ◽  
Vol 24 (4) ◽  
pp. 667-694 ◽  
Author(s):  
Stjepan Picek ◽  
Claude Carlet ◽  
Sylvain Guilley ◽  
Julian F. Miller ◽  
Domagoj Jakobovic
Keyword(s):  
Evolutionary Algorithms ◽  
Genetic Programming ◽  
Evolutionary Computation ◽  
Boolean Functions ◽  
Coding Theory ◽  
Design Criteria ◽  
Hamming Weight ◽  
High Quality ◽  
Distinct Role

The role of Boolean functions is prominent in several areas including cryptography, sequences, and coding theory. Therefore, various methods for the construction of Boolean functions with desired properties are of direct interest. New motivations on the role of Boolean functions in cryptography with attendant new properties have emerged over the years. There are still many combinations of design criteria left unexplored and in this matter evolutionary computation can play a distinct role. This article concentrates on two scenarios for the use of Boolean functions in cryptography. The first uses Boolean functions as the source of the nonlinearity in filter and combiner generators. Although relatively well explored using evolutionary algorithms, it still presents an interesting goal in terms of the practical sizes of Boolean functions. The second scenario appeared rather recently where the objective is to find Boolean functions that have various orders of the correlation immunity and minimal Hamming weight. In both these scenarios we see that evolutionary algorithms are able to find high-quality solutions where genetic programming performs the best.

scholarly journals Essential role of Mecp2 in the regulation of myofibroblast differentiation

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Biao Hu ◽  
Mehrnaz Gharaee‐Kermani ◽  
Zhe Wu ◽  
Sem H. Phan
Keyword(s):  
Essential Role ◽  
Myofibroblast Differentiation
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