scholarly journals Adalimumab ameliorates memory impairments and neuroinflammation in chronic cerebral hypoperfusion rats

Aging ◽  
2021 ◽  
Author(s):  
Jing-Jing Xu ◽  
Si Guo ◽  
Rui Xue ◽  
Lin Xiao ◽  
Jun-Na Kou ◽  
...  
Keyword(s):  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments

scholarly journals Alternations of Septal-hippocampal System in the Adult Wistar Rat with Spatial Memory Impairments Induced by Chronic Cerebral Hypoperfusion

2011 ◽  
Vol 20 (2) ◽  
pp. 92-99 ◽  
Author(s):  
Bo-Ryoung Choi ◽  
Kyoung Ja Kwon ◽  
Seung Hwa Park ◽  
Won Kyung Jeon ◽  
Seol-Heui Han ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Wistar Rat ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments

scholarly journals Electroacupuncture Improved Chronic Cerebral Hypoperfusion-Induced Anxiety-Like Behavior and Memory Impairments in Spontaneously Hypertensive Rats by Downregulating the ACE/Ang II/AT1R Axis and Upregulating the ACE2/Ang-(1-7)/MasR Axis

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Peipei Feng ◽  
Zemin Wu ◽  
Hao Liu ◽  
Yafang Shen ◽  
Xu Yao ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Ang Ii ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Memory Impairments

Electroacupuncture (EA) can effectively alleviate anxiety disorders and memory impairments caused by various neurodegenerative diseases; however, the molecular mechanisms underlying its neuroprotective effects are unclear. Previous studies have shown that the renin-angiotensin system (RAS) comprises of two axes with mutual antagonism: the classical angiotensin converting enzyme/angiotensin II/angiotensin II type 1 receptor (ACE/Ang II/AT1R) axis and the protective angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor (ACE2/Ang-(1-7)/MasR) axis. In this study, we observed that chronic cerebral hypoperfusion (CCH) mediated anxiety-like behavior and memory impairments in spontaneously hypertensive rats (SHR) via upregulation of the hippocampal classical axis (ACE/Ang II/AT1R) and the partial hippocampal protective axis (ACE2/Ang-(1-7)). However, Ang II levels were much higher than those of Ang-(1–7), indicating that the ACE/Ang II/AT1R axis plays a dominant role in the comorbidity of CCH and hypertension. Moreover, candesartan cilexetil (Canc) and perindopril (Peril) were used as positive control drugs. We found that EA, Canc, and Peril attenuated CCH-induced anxiety-like behavior and memory impairments in SHR, potentially via downregulation of the hippocampal classical axis (ACE/Ang II/AT1R) and upregulation of the whole hippocampal protective axis (ACE2/Ang-(1-7)/MasR). These results suggest that EA therapy for CCH with hypertension may be mediated by two hippocampal RAS axes.

scholarly journals Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ling-Yong Xiao ◽  
Jing-Wen Yang ◽  
Xue-Rui Wang ◽  
Yang Ye ◽  
Na-Na Yang ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Vessel Occlusion ◽  
Memory Impairments ◽  
Beneficial Effects ◽  
Hippocampus Dependent Memory

Alteration of dopamine (DA) and noradrenaline (NA) contributes to cognitive function. Acupuncture has been shown to affect DA and NA in chronic cerebral hypoperfusion (CCH) rats. However, the effect of acupuncture on DA-β-hydroxylase (DBH), the biosynthetic enzyme of NA, remains unknown. In CCH rats we established chronic hypoperfusion by bilateral common carotid artery occlusion (two-vessel occlusion, 2VO) and treated them with acupuncture. Acupuncture displayed beneficial effects on hippocampus-dependent memory impairments, including nonspatial and spatial memory. That is also reflected in hippocampus long-term-potentiation (LTP). Moreover, DBH expression in the hippocampus and DBH activity in cerebrospinal fluid were upregulated after acupuncture treatment. In conclusion, these in vivo findings suggest that acupuncture exerts a therapeutic effect on hippocampus-dependent memory and hippocampus LTP in CCH rats, which may be partially related to the modulation of DBH in the hippocampus.

Harpagoside Rescues the Memory Impairments in Chronic Cerebral Hypoperfusion Rats by Inhibiting PTEN Activity

2018 ◽  
Vol 63 (2) ◽  
pp. 445-455 ◽  
Author(s):  
Chen Chen ◽  
Haifeng Zhang ◽  
Hongliang Xu ◽  
Rui Xue ◽  
Yake Zheng ◽  
...  
Keyword(s):  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments

scholarly journals Effects ofFructus mumeExtract on MAPK and NF-κB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Won Kyung Jeon ◽  
Jinhua Ma ◽  
Bo-Ryoung Choi ◽  
Seol-Heui Han ◽  
Qinghao Jin ◽  
...  
Keyword(s):  
Microglial Activation ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Artery Occlusion ◽  
Chronic Cerebral Hypoperfusion ◽  
Mitogen Activated Protein Kinase ◽  
Daily Administration ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments ◽  
The Status

Fructus mume(F. mume) has been used as a medicinal food in Japan and has been reported to have anti-inflammatory effects in inflammatory bowel disease and macrophage-mediated inflammation. We investigated the effects ofF. mumeextracts on cognitive dysfunction in rats with chronic cerebral hypoperfusion and the molecular mechanisms underlying these effects. Chronic cerebral hypoperfusion was induced in male Wister rats by bilateral common artery occlusion (BCCAo). Daily administration ofF. mumeextracts was started on day 20 after post-BCCAo and continued for 40 days. The status of hippocampus-dependent memory was evaluated in control rats, rats with chronic cerebral hypoperfusion, and rats with chronic cerebral hypoperfusion that were administeredF. mume. The levels of microglial activation were measured in the hippocampus and the fimbria of hippocampus, and expression levels of hippocampal mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) were examined. Rats that received chronic cerebral hypoperfusion showed spatial memory impairments relative to the control rats; these impairments were reduced by daily administration ofF. mume. Administration ofF. mumemitigated the microglial activation and alterations of hippocampal MAPK and NF-κB signaling in the rats with chronic cerebral hypoperfusion. These results indicate thatF. mumemay possess therapeutic potential for the prevention of vascular dementia via inhibition of inflammatory processes.

scholarly journals Ameliorating Effects of Ethanol Extract ofFructus mumeon Scopolamine-Induced Memory Impairment in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Min-Soo Kim ◽  
Won Kyung Jeon ◽  
Kye Wan Lee ◽  
Yu Hwa Park ◽  
Jung-Soo Han
Keyword(s):  
Cognitive Function ◽  
Morris Water Maze ◽  
Water Maze ◽  
Memory Impairment ◽  
Cholinergic Neurons ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments ◽  
Morris Water Maze Task ◽  
Increased Activity

We previously reported thatFructus mume(F. mume) extract shows protective effects on memory impairments and anti-inflammatory effects induced by chronic cerebral hypoperfusion. Neurodegeneration of basal cholinergic neurons is also observed in the brain with chronic cerebral hypoperfusion. Therefore, the present study was conducted to examine whetherF. mumeextracts enhance cognitive function via the action of cholinergic neuron using a scopolamine-induced animal model of memory impairments.F. mume(50, 100, or 200 mg/kg) was administered to C57BL/6 mice for 14 days (days 1–14) and memory impairment was induced by scopolamine (1 mg/kg), a muscarinic receptor antagonist for 7 days (days 8–14). Spatial memory was assessed using Morris water maze and hippocampal level of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) was examined by ELISA and immunoblotting. Mice that received scopolamine alone showed impairments in acquisition and retention in Morris water maze task and increased activity of AChE in the hippocampus. Mice that receivedF. mumeand scopolamine showed no scopolamine-induced memory impairment and increased activity of AChE. In addition, treatments ofF. mumeincreased ChAT expression in the hippocampus. These results indicated thatF. mumemight enhance cognitive function via action of cholinergic neurons.

scholarly journals Contribution of p38 MAPK to the Ameliorating Effect of Enriched Environment on the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion

2016 ◽  
Vol 40 (3-4) ◽  
pp. 549-557 ◽  
Author(s):  
Yu-Wang Li ◽  
Qing-Yun Li ◽  
Jin-Hua Wang ◽  
Xiao-Lin Xu
Keyword(s):  
P38 Mapk ◽  
Cognitive Deficits ◽  
Mapk Signaling ◽  
Selective Inhibitor ◽  
Enriched Environment ◽  
Chronic Cerebral Hypoperfusion ◽  
Mitogen Activated Protein Kinase ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments ◽  
Mitogen Activated Protein

Background/Aims: An enriched environment (EE) ameliorates learning and memory impairments induced by chronic cerebral hypoperfusion, and the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway exerts both beneficial and deleterious effects on the nervous system during the progression of ischemia. Methods: The present study investigated whether p38 MAPK participates in the process by which EE exposure ameliorates the cognitive deficits induced by chronic cerebral hypoperfusion. Results: EE exposure significantly enhanced the cognitive performance of vascular dementia (VD) model rats, and p38 MAPK protein decreased in parallel with cognitive improvements. Inhibition of p38 MAPK function by its selective inhibitor SB203580 improved the cognition index of VD rats and upregulated p38 MAPK expression with p38 MAPK antisense oligodeoxynucleotides. This impaired cognition in VD rats could not be rescued by EE exposure. Conclusion: p38 MAPK participates in the process by which EE exposure ameliorates cognitive deficits induced by chronic cerebral hypoperfusion.

Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model

2016 ◽  
Vol 615 ◽  
pp. 9-14 ◽  
Author(s):  
Chunjie Nie ◽  
Huijuan Nie ◽  
Yin Zhao ◽  
Jianzhao Wu ◽  
Xiaojian Zhang
Keyword(s):  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Memory Impairments
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