scholarly journals Long intergenic noncoding RNA 00665 promotes proliferation and inhibits apoptosis in colorectal cancer by regulating miR-126-5p

Aging ◽  
2021 ◽  
Author(s):  
Chang-Liang Wu ◽  
Ti-Dong Shan ◽  
Yue Han ◽  
Yan Kong ◽  
Yuan-Bo Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Noncoding Rna ◽  
Long Intergenic Noncoding Rna

scholarly journals LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Yun Wang ◽  
Jia-Huan Lu ◽  
Qi-Nian Wu ◽  
Ying Jin ◽  
De-Shen Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Target ◽  
Noncoding Rna ◽  
Aerobic Glycolysis ◽  
Poor Overall Survival ◽  
Normal Tissues ◽  
In Vivo Experiments ◽  
Long Intergenic Noncoding Rna

Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target. Methods We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with LINRIS (Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with LINRIS inhibited were tested in vitro and in vivo. Results LINRIS was upregulated in CRC tissues from patients with poor overall survival (OS), and LINRIS inhibition led to the impaired CRC cell line growth. Moreover, knockdown of LINRIS resulted in a decreased level of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a newly found N6-methyladenosine (m6A) ‘reader’. LINRIS blocked K139 ubiquitination of IGF2BP2, maintaining its stability. This process prevented the degradation of IGF2BP2 through the autophagy-lysosome pathway (ALP). Therefore, knockdown of LINRIS attenuated the downstream effects of IGF2BP2, especially MYC-mediated glycolysis in CRC cells. In addition, the transcription of LINRIS could be inhibited by GATA3 in CRC cells. In vivo experiments showed that the inhibition of LINRIS suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models. Conclusion LINRIS is an independent prognostic biomarker for CRC. The LINRIS-IGF2BP2-MYC axis promotes the progression of CRC and is a promising therapeutic target.

Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

2013 ◽  
Vol 12 (4) ◽  
pp. 261-266 ◽  
Author(s):  
Haiyan Zhai ◽  
Andrew Fesler ◽  
Kristina Schee ◽  
Øystein Fodstad ◽  
Kjersti Flatmark ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Noncoding Rna ◽  
Long Intergenic Noncoding Rna

Long intergenic noncoding RNA 00908 promotes proliferation and inhibits apoptosis of colorectal cancer cells by regulating KLF5 expression

2020 ◽  
Vol 236 (2) ◽  
pp. 889-899
Author(s):  
Ti‐Dong Shan ◽  
Zi‐Bin Tian ◽  
Qian Li ◽  
Yue‐ Ping Jiang ◽  
Fu‐Guo Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Noncoding Rna ◽  
Colorectal Cancer Cells ◽  
Long Intergenic Noncoding Rna ◽  
Klf5 Expression

scholarly journals The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR-143

2017 ◽  
Vol 8 (5) ◽  
pp. e2778-e2778 ◽  
Author(s):  
Feng-Ting Huang ◽  
Wen-Ying Chen ◽  
Zhi-Qiang Gu ◽  
Yan-Yan Zhuang ◽  
Chu-Qiang Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Noncoding Rna ◽  
The Novel ◽  
Long Intergenic Noncoding Rna ◽  
Colorectal Cancer Progression

scholarly journals LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathway

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo Jia ◽  
Junfeng Dao ◽  
Jiusong Han ◽  
Zhijie Huang ◽  
Xiang Sun ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Luciferase Reporter ◽  
Cell Cycle Regulators ◽  
Normal Tissues ◽  
Stat3 Signaling ◽  
Long Intergenic Noncoding Rna

Abstract Background Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the role of LINC00958 and its downstream mechanisms in TSCC is still unknown. Methods The effect of LINC00958 on TSCC cells proliferation and growth were assessed by CCK-8, colony formation, 5-Ethynyl-2′-deoxyuridline (EdU) assay and flow cytometry assays in vitro and tumor xenograft model in vivo. Bioinformatics analysis was used to predict the target of LINC00958 in TSCC, which was verified by RNA immunoprecipitation and luciferase reporter assays. Results LINC00958 was increased in TSCC tissues, and patients with high LINC00958 expression had a shorter overall survival. LINC00958 knockdown significantly decreased the growth rate of TSCC cells both in vitro and in vivo. In mechanism, LINC00958 acted as a ceRNA by competitively sponging miR-211-5p. In addition, we identified CENPK as a direct target gene of miR-211-5p, which was higher in TSCC tissues than that in adjacent normal tissues. Up-regulated miR-211-5p or down-regulated CENPK could abolish LINC00958-induced proliferation promotion in TSCC cells. Furthermore, The overexpression of CENPK promoted the expression of oncogenic cell cycle regulators and activated the JAK/STAT3 signaling. Conclusions Our findings suggested that LINC00958 is a potential prognostic biomarker in TSCC.

Long noncoding RNA LINC00978 acts as a potential diagnostic biomarker in patients with colorectal cancer

2021 ◽  
pp. 104666
Author(s):  
Majid Ghasemian ◽  
Masoumeh Rajabibazl ◽  
Reza Mirfakhraie ◽  
Amirnader Emami Razavi ◽  
Hossein Sadeghi
Keyword(s):  
Colorectal Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Diagnostic Biomarker
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