scholarly journals Circulating perilipin 2 levels are associated with fat mass, inflammatory and metabolic markers and are higher in women than men

Aging ◽  
2021 ◽  
Author(s):  
Maria Conte ◽  
Aurelia Santoro ◽  
Salvatore Collura ◽  
Morena Martucci ◽  
Giuseppe Battista ◽  
...  
Keyword(s):  
Fat Mass ◽  
Metabolic Markers ◽  
Perilipin 2

scholarly journals Sex Related Impact of Maternal Adiposity on Neonatal Adiposity and Metabolic Status

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1033-1033
Author(s):  
Nicole Marshall ◽  
Kent Thornburg ◽  
Jonathan Purnell
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Gestational Age ◽  
Female Infant ◽  
P Value ◽  
Maternal Body ◽  
Metabolic Markers ◽  
Neonatal Adiposity ◽  
Infant Birth ◽  
Maternal Adiposity

Abstract Objectives Women with obesity are at increased risk to have large for gestational age neonates. Our study aimed to understand the association between maternal adiposity and neonatal adiposity and metabolic markers. Methods This was a prospective cohort study of healthy women with singleton pregnancies enrolled at 12–16 or 37–38 weeks gestation. Maternal fat mass was determined by air displacement plethysmography. Infant fat mass was determined by skin fold thickness. Cord blood was collected at delivery. Linear regression was used to determine the association of maternal adiposity with infant birth weight, fat mass, and glucose, insulin, lipid, and adipokine levels. Results One hundred eighty five women were enrolled. Demographics (mean, min-max): maternal age 32.9 years (18.8–43.8), maternal pre-pregnancy BMI 27.2 kg/m,2 (17.5–54.0), gestational age at delivery 39.5 weeks (34–42), birthweight 3.46 kg (2.1–5.0). Newborn leptin levels were associated with maternal pre-pregnancy BMI (p-value 0.0070, r2 0.0468), maternal fat mass at 12 and 37 weeks, and maternal %body fat at 12 and 37 weeks. There were no others associations among maternal adiposity and infant adiposity or metabolic markers. When analyzed by fetal sex, female infant birthweight was associated with maternal pre-pregnancy BMI (p-value 0.025, r2 0.055), female fat mass was associated with pre-pregnancy BMI and maternal fat mass at 37 weeks (p-value 0.024, r2 0.069), and female %body fat was associated with maternal fat mass at 37 weeks (p-value 0.0239, r2 0.069). Female infant HDL was lower at birth with increasing maternal fat mass at 12 weeks gestation (p-value 0.0405, r2 0.121). Female infant leptin levels were increased with maternal adiposity including pre-pregnancy BMI, maternal fat mass at 37 weeks, maternal %body fat, and gestational weight gain. Female infant adiponectin levels were lower with increasing maternal pre-pregnancy BMI (p-value 0.0468, r2 0.0538). There were no associations between maternal adiposity and male infant adiposity or metabolic markers. Conclusions Maternal adiposity was associated with increased neonatal leptin levels, but not neonatal adiposity or metabolic markers. Female, but not male, infants had higher birthweight, fat mass, %body fat, and leptin levels and lower HDL and adiponectin levels with increasing maternal adiposity. Funding Sources NICHD.

scholarly journals Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui Chen ◽  
Gerard Li ◽  
Yik Lung Chan ◽  
Hui Emma Zhang ◽  
Mark D. Gorrell ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Fat Mass ◽  
High Fat Diet ◽  
Metabolic Profiles ◽  
Adaptive Responses ◽  
Metabolic Markers ◽  
Future Studies ◽  
Glucose Profiles ◽  
Liver Changes ◽  
Improve Glucose Tolerance

Tobacco smoking increases the risk of metabolic disorders due to the combination of harmful chemicals, whereas pure nicotine can improve glucose tolerance. E-cigarette vapour contains nicotine and some of the harmful chemicals found in cigarette smoke at lower levels. To investigate how e-vapour affects metabolic profiles, male Balb/c mice were exposed to a high-fat diet (HFD, 43% fat, 20kJ/g) for 16weeks, and e-vapour in the last 6weeks. HFD alone doubled fat mass and caused dyslipidaemia and glucose intolerance. E-vapour reduced fat mass in HFD-fed mice; only nicotine-containing e-vapour improved glucose tolerance. In chow-fed mice, e-vapour increased lipid content in both blood and liver. Changes in liver metabolic markers may be adaptive responses rather than causal. Future studies can investigate how e-vapour differentially affects metabolic profiles with different diets.

Novel genes on rat chromosome 10 are linked to body fat mass, preadipocyte number and adipocyte size

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
A Weingarten ◽  
L Turchetti ◽  
K Krohn ◽  
M Kern ◽  
I Klöting ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Adipocyte Size ◽  
Chromosome 10 ◽  
Novel Genes

Gene expression analysis of metabolic markers during bone regeneration in a rat model

2014 ◽  
Vol 23 (03) ◽  
pp. 207-211
Author(s):  
C. Kasch ◽  
A. Osterberg ◽  
Thordis Granitzka ◽  
T. Lindner ◽  
M. Haenle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Analysis ◽  
Saline Solution ◽  
Female Rats ◽  
Synthesis Rate ◽  
Metabolic Markers ◽  
Expression Levels ◽  
Fibrotic Tissue ◽  
Intermittent Pth ◽  
Lower Expression

SummaryThe RANK/RANKL/OPG system plays an important role in the regulation of bone metabolism and bony integration around implants. The aim of this study was to analyse gene expression of OPG, RANK, and RANKL in regenerating bone during implant integration. Additionally, the effect of intermittent para - thyroid hormone (PTH) treatment was analysed. A titanium chamber was implanted in the proximal tibiae of 48 female rats. The animals received either human PTH or saline solution (NaCl). After 21 and 42 days, RNA was isolated from tissue adjacent to the implant and expression of RANK, RANKL, and OPG was analysed. After 21 days, very low expression levels of all genes were shown. In contrast, increased gene expression after 42 days was determined. Expression of RANK and RANKL was lower than that for OPG. The lower expression levels after 21 days might be due to still ossifying, fibrotic tissue around the titanium chamber. An increased OPG synthesis rate associated with decreased RANKL expression after 42 days revealed bone-forming processes. Despite significant differences in gene expression between the time points, only slight differences were observed between application of intermittent PTH and NaCl after a period of 42 days.

Ziprasidone's Effect on Metabolic Markers in Patients with Diabetes and Chronic Schizophrenia

2012 ◽  
Vol 5 (4) ◽  
pp. 185-192 ◽  
Author(s):  
J. Lindenmayer ◽  
Frank Tedeschi ◽  
Anna Yusim ◽  
Anzalee Khan ◽  
Saurabh Kaushik ◽  
...  
Keyword(s):  
Chronic Schizophrenia ◽  
Metabolic Markers ◽  
Patients With Diabetes

Variable relationship of fat mass and bone with pubertal staging in obese and normal weight Indian children and adolescents

2013 ◽  
Author(s):  
Khadilkar Anuradha ◽  
Ekbote Veena ◽  
Pandit Deepa ◽  
Chiplonkar Shashi ◽  
Zulf Mughal M ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Fat Mass ◽  
Normal Weight ◽  
Indian Children ◽  
Relationship Of

Lean and fat mass in Ukrainian women of different age

2013 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych
Keyword(s):  
Fat Mass

Metabolic improvement after treatment of acromeglay is determined by the increase of gynoid fat mass and the decrease of serum vaspin and IGF1

2014 ◽  
Author(s):  
Nicoleta C. Olarescu ◽  
Ansgar Heck ◽  
Kristin Godang ◽  
Thor Ueland ◽  
Jens Bollerslev
Keyword(s):  
Fat Mass ◽  
Gynoid Fat

Glucocorticoid-induced lipolysis across human ageing and the relationship to fat mass and androgens

2015 ◽  
Author(s):  
Zaki Hassan-Smith ◽  
Angela Taylor ◽  
Beverly Hughes ◽  
Theresa Brady ◽  
Pamela Jones ◽  
...  
Keyword(s):  
Fat Mass ◽  
Human Ageing ◽  
The Relationship
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