scholarly journals Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study

Aging ◽  
2021 ◽  
Author(s):  
Sin-Mei Guo ◽  
Yen-Tze Liu ◽  
Sin-Ru He ◽  
Ming-Shiang Wu ◽  
Wei-Ting Tseng ◽  
...  
Keyword(s):  
Older Adults ◽  
Uric Acid ◽  
Cohort Study ◽  
Grip Strength ◽  
Clinical Biomarkers ◽  
Biomarkers Of Aging ◽  
Relationship Of ◽  
Differential Relationship

Challenging the relationship of grip strength with cognitive status in older adults

2020 ◽  
Author(s):  
Andrew Hooyman ◽  
Michael Malek‐Ahmadi ◽  
Elizabeth B. Fauth ◽  
Sydney Y. Schaefer
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Cognitive Status ◽  
Relationship Of ◽  
The Relationship

scholarly journals High blood uric acid is associated with reduced risks of mild cognitive impairment among older adults in China: a 9-year prospective cohort study

2021 ◽  
Author(s):  
Chen Chen ◽  
Xueqin Li ◽  
Yuebin Lv ◽  
Zhaoxue Yin ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Older Adults ◽  
Uric Acid ◽  
Cohort Study ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthy Aging ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Blood Uric Acid ◽  
Quartile Group

Abstract Background: It remains unsolved that whether blood uric acid (UA) is a neuroprotective or neurotoxic agent. This study aimed to evaluate the longitudinal association of blood UA with mild cognitive impairment (MCI) among older adults in China. Methods: A total of 3103 older adults (aged 65+ years) free of MCI at baseline were included from the Healthy Aging and Biomarkers Cohort Study (HABCS). Blood UA level was determined by the uricase colorimetry assay and analyzed as categorical (by quartile) variables. Global cognition was assessed using the Mini-Mental State Examination four times between 2008 and 2017, with a score below 24 being considered as MCI. Cox proportional hazards models were used to examine the associations. Results: During a 9-year follow-up, 486 (15.7%) participants developed MCI. After adjustment for all covariates, higher UA had a dose-response association with a lower risk of MCI (all P for trend< 0.05). Participants in the highest UA quartile group had a reduced risk (hazard ratio [HR], 0.73; 95% [CI]: 0.55-0.96) of MCI, compared with those in the lowest quartile group. The associations were still robust even when considering death as a competing risk. Subgroup analyses revealed that these associations were statistically significant in younger older adults (65-79 years) and those without hyperuricemia. Conclusions: High blood UA level is associated with reduced risks of MCI among Chinese older adults, highlighting the potential of managing UA in daily life for maintaining late-life cognition.

scholarly journals High Blood Uric Acid Is Associated With Reduced Risks of Mild Cognitive Impairment Among Older Adults in China: A 9-Year Prospective Cohort Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Chen Chen ◽  
Xueqin Li ◽  
Yuebin Lv ◽  
Zhaoxue Yin ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Older Adults ◽  
Uric Acid ◽  
Cohort Study ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthy Aging ◽  
Continuous Variable ◽  
Cox Proportional Hazards ◽  
Blood Uric Acid ◽  
Quartile Group

Background: It remains unsolved that whether blood uric acid (UA) is a neuroprotective or neurotoxic agent. This study aimed to evaluate the longitudinal association of blood UA with mild cognitive impairment (MCI) among older adults in China.Methods: A total of 3,103 older adults (aged 65+ years) free of MCI at baseline were included from the Healthy Aging and Biomarkers Cohort Study (HABCS). Blood UA level was determined by the uricase colorimetry assay and analyzed as both continuous and categorical (by quartile) variables. Global cognition was assessed using the Mini-Mental State Examination four times between 2008 and 2017, with a score below 24 being considered as MCI. Cox proportional hazards models were used to examine the associations.Results: During a 9-year follow-up, 486 (15.7%) participants developed MCI. After adjustment for all covariates, higher UA had a dose-response association with a lower risk of MCI (all Pfor  trend &lt; 0.05). Participants in the highest UA quartile group had a reduced risk [hazard ratio (HR), 0.73; 95% (CI): 0.55–0.96] of MCI, compared with those in the lowest quartile group. The associations were still robust even when considering death as a competing risk. Subgroup analyses revealed that these associations were statistically significant in younger older adults (65–79 years) and those without hyperuricemia. Similar significant associations were observed when treating UA as a continuous variable.Conclusions: High blood UA level is associated with reduced risks of MCI among Chinese older adults, highlighting the potential of managing UA in daily life for maintaining late-life cognition.

scholarly journals Differential Relationship of Grip Strength With Body Composition and Lifestyle Factors Between Indian Urban and Rural, Boys and Girls

2021 ◽  
Author(s):  
Veena Ekbote ◽  
Prerna Patel ◽  
Sonal Kasture ◽  
Smruti Vispute ◽  
Vaman Khadilkar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Size ◽  
Grip Strength ◽  
Lifestyle Factors ◽  
Indian Children ◽  
Cross Sectional ◽  
School Based ◽  
Study Association ◽  
Relationship Of ◽  
Differential Relationship

Abstract Grip strength (GS) is used as an index of overall health in children. The objectives of our study were to assess GS, gender differences in GS in 9 -18 year old urban (U) and rural (R) Indian children, study association of GS with body composition (BC) and assess determinants. This was part of a multicentre, cross sectional, school-based study (n=1978, mean age 13.3 ± 2.2 years) from 3 U and R states. Anthropometry, BC, dietary intake, physical activity, sunlight exposure and GS (in Kg) measurements were performed. The mean GS increased with age but plateaued in girls after 12 years; was higher in boys (19.6 ± 9.2) than girls (14.3 ± 5.3) (p < 0.05). Mean GS was higher in U (21.05 ± 9.7) than in R boys (17.8 ± 8.2) (p < 0.05), comparable in U (14.9 ± 5.2) and R girls (13.8 ± 5.5). GS in girls remained lower than boys after adjusting for muscle mass (MM). Difference between boys and girls reduced after body size (BMI) correction, but remained low in girls plateauing after 15 years. MM and age were significant determinants of GS in all children. On addition of lifestyle factors, GS was explained to varied degrees, the least in U girls, followed by R girls and R boys and the most in U boys. Conclusion: In boys, nutrition though body size and composition was largely responsible for the differences in GS and in girls, additionally socio-cultural factors also possibly impact GS.

Physical Activity in Aging Population

2019 ◽  
Vol 5 (3) ◽  
pp. 74
Author(s):  
Rezarta Stena ◽  
Klara Hysenaj ◽  
Mitilda Gugu Karoli ◽  
Armelda Teta ◽  
Gjergji Doka
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Heart Rate ◽  
Pain Intensity ◽  
Range Of Motion ◽  
Training Program ◽  
Grip Strength ◽  
Upper Limb ◽  
Hand Grip ◽  
Trunk Flexibility

It is known that worldwide populations are aging, and also that physical activity can play an important role in minimizing impairments characteristic of old age. Adopting a more active lifestyle and doing regular physical activity, including aerobic and resistance exercises, daily walking etc. have been demonstrated to improve cardiovascular, respiratory, and musculoskeletal parameters in older adults. We assessed a potential participant from Elbasan (Albania), 67 years, for eligibility to participate in a 5 month training program. The subject gave written informed consent before inclusion.The following parameters were measured at the beginning (baseline) and end of the training period: BMI, body fat percentage, hand grip strength, lower/upper limb and trunk flexibility and range of motion, heart rate, balance, pain intensity, as well as VO2 max, directly and/or an estimate using the Rockport fitness test estimate. An initial evaluation was carried out just before starting the training (baseline). A second evaluation was made 5 months after starting the program of physical exercise (post training). Each evaluation included the recording of health related events, such as any changes in previous symptoms, as well as measurements of balance, flexibility, body composition, coordination, muscle strength, and aerobic capacity, to detect any changes that might have been induced specifically by physical activity. The subject’s attendance and participation in the program was also recorded. Range of motion for each part evaluated (trunk, hip, cervical region and shoulder) is improved about 15-20° degree. BMI, hand grip strength, lower/upper limb and trunk flexibility, heart rate, balance, pain intensity, VO2 max are also improved after training program. Following a training program or a regular physical activity in older adults minimise impairments characteristics in this age and cardiovascular, respiratory, and musculoskeletal parameters. According to the low importance shown in my country for the physical activity in older adults, I want to emphasize the importance of state structures involvement and the sensibilization of this group of age to stimulate an actively participation in physical training programs followed by professionals for bests life parameters. A higher investment for this age group, building as many facilities as possible for activation and spending quality free time, hiring more physiotherapists in nursing homes will increase life motivation and improve the quality and the parameters of living.

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