scholarly journals Exosomal circRNAs contribute to intestinal development via the VEGF signalling pathway in human term and preterm colostrum

Aging ◽  
2021 ◽  
Author(s):  
Yahui Zhou ◽  
Zhangbin Yu ◽  
Xingyun Wang ◽  
Wenjuan Chen ◽  
Yiwen Liu ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Intestinal Development ◽  
Vegf Signalling

scholarly journals Inhibition of the VEGF signalling pathway and glomerular disorders

2014 ◽  
Vol 30 (9) ◽  
pp. 1449-1455 ◽  
Author(s):  
Mario Ollero ◽  
Djillali Sahali
Keyword(s):  
Signalling Pathway ◽  
Vegf Signalling

scholarly journals Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway

2020 ◽  
Vol 22 ◽  
pp. 92-100 ◽  
Author(s):  
Wen-Xiang Cheng ◽  
Huan Huang ◽  
Jian-Hai Chen ◽  
Tian-Tian Zhang ◽  
Guo-Yuan Zhu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signalling Pathway ◽  
Vegf Signalling

61 The VEGF signalling pathway and the chromatin environment in lung cancer

Lung Cancer ◽  
2007 ◽  
Vol 57 ◽  
pp. S17
Author(s):  
N. Al-Sarraf ◽  
A.M. Baird ◽  
G. Pidgeon ◽  
E. McGovern ◽  
K.J. O'Byrne ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signalling Pathway ◽  
Vegf Signalling

scholarly journals Protocatechuic Acid Induces Angiogenesis through PI3K-Akt-eNOS-VEGF Signalling Pathway

2013 ◽  
Vol 113 (4) ◽  
pp. 221-227 ◽  
Author(s):  
Zechun Kang ◽  
Haibo Zhu ◽  
Wanglin Jiang ◽  
Shuping Zhang
Keyword(s):  
Protocatechuic Acid ◽  
Signalling Pathway ◽  
Vegf Signalling

Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1α/VEGF signalling pathway in the bone environment

2020 ◽  
Vol 884 ◽  
pp. 173394 ◽  
Author(s):  
Qiaoyun Guo ◽  
Jing Yang ◽  
Yumeng Chen ◽  
Xin Jin ◽  
Zongmin Li ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Vegf Signalling

scholarly journals Asparagus Polysaccharide Suppresses the Migration, Invasion, and Angiogenesis of Hepatocellular Carcinoma Cells Partly by Targeting the HIF-1α/VEGF Signalling Pathway In Vitro

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Wei Cheng ◽  
Ziwei Cheng ◽  
Dongwei Xing ◽  
Minguang Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptional Activation ◽  
Umbilical Vein ◽  
Signalling Pathway ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Antitumor Effects ◽  
Vegf Signalling ◽  
Hcc Cells

Hypoxia-inducible factor-1α (HIF-1α) plays a key role by triggering the transcriptional activation of a number of genes involved in migration, invasion, and angiogenesis in hepatocellular carcinoma (HCC). Thus, suppressing tumour growth by targeting the HIF-1α/VEGF signalling pathway represents a promising strategy for the treatment of HCC. In our previous studies, we found that asparagus polysaccharide (ASP) suppressed the proliferation and promoted the apoptosis of HCC cells both in vivo and in vitro. To further explore the potential mechanisms of the antitumor effects of ASP in HCC, we investigated effects of ASP on the migration, invasion, and angiogenesis of HCC cells (SK-Hep1 and Hep-3B) using an in vitro experimental model. First, we found that ASP effectively suppressed the proliferation of the SK-Hep1 and Hep-3B cells but did not cause significant cytotoxicity in normal liver cells (L-O2). Then, we found that ASP inhibited the migration and invasion of the SK-Hep1 and Hep-3B cells and HCC cells-induced angiogenesis of human umbilical vein endothelial cells in a concentration-dependent manner. Mechanistic studies revealed that the inhibition of migration, invasion, and angiogenesis by ASP in the SK-Hep1 and Hep-3B cells might occur via the downregulation of HIF-1α/VEGF signalling pathway. Finally, our results also showed that the inhibition of HIF-1α by ASP may be mediated through the downregulation of the phosphorylation levels of AKT, mTOR, and ERK. In conclusion, our results suggest that ASP suppresses the migration, invasion, and angiogenesis of HCC cells partly via inhibiting the HIF-1α/VEGF signalling pathway.

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