scholarly journals The critical role of peroxiredoxin-2 in colon cancer stem cells

Aging ◽  
2021 ◽  
Author(s):  
Linglong Peng ◽  
Yongfu Xiong ◽  
Rong Wang ◽  
Ling Xiang ◽  
He Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Critical Role ◽  
Peroxiredoxin 2 ◽  
Colon Cancer Stem Cells

scholarly journals CD147 Promotes Cell Small Extracellular Vesicles Release during Colon Cancer Stem Cells Differentiation and Triggers Cellular Changes in Recipient Cells

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 260 ◽  
Author(s):  
Donatella Lucchetti ◽  
Filomena Colella ◽  
Luigi Perelli ◽  
Claudio Ricciardi-Tenore ◽  
Federica Calapà ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Multivesicular Body ◽  
Cellular Changes ◽  
Colon Cancer Stem Cells ◽  
Colorectal Cancer Stem Cells

Cancer cells secrete small extracellular vesicles (sEVs) that are involved in the remodeling of tumor microenvironment (TME) and can promote tumor progression. The role of sEVs and their molecular key players in colon cancer stem cells differentiation are poorly understood. This study aimed to analyze the role and content of sEVs released during the differentiation of colorectal cancer stem cells. Here we show that sEVs secretion during colon cancer stem cells differentiation is partially controlled by CD147, a well-known player involved in colon cancer tumorigenesis. CD147 + sEVs activate a signaling cascade in recipient cells inducing molecular invasive features in colon cancer cells. CD147 knockdown as well as anti-CD147 antibodies impaired sEVs release and downstream effects on recipient cells and blocking multivesicular body maturation prevented sEVs release during the differentiation. Our findings reveal a functional role of CD147 in promoting sEVs release during the differentiation of colon cancer stem cells and in triggering cellular changes in recipient cells.

Sa1156 ROLE OF WNT NON-CANONICAL PATHWAY IN MAINTENANCE OF COLON CANCER STEM CELLS.

2020 ◽  
Vol 158 (6) ◽  
pp. S-293
Author(s):  
Aditi Bhattacharya ◽  
Devanjan Dey ◽  
Janvie Manhas ◽  
Muzaffar Bhat ◽  
Jayanth Kumar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Canonical Pathway ◽  
Colon Cancer Stem Cells

scholarly journals Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107514 ◽  
Author(s):  
Constanze Buhrmann ◽  
Patricia Kraehe ◽  
Cora Lueders ◽  
Parviz Shayan ◽  
Ajay Goel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Tumor Microenvironment ◽  
Cancer Stem Cells ◽  
Potential Role ◽  
Stromal Fibroblasts ◽  
Colon Cancer Stem Cells

scholarly journals Crucial Role of Interleukin-4 in the Survival of Colon Cancer Stem Cells: Figure 1.

2008 ◽  
Vol 68 (11) ◽  
pp. 4022-4025 ◽  
Author(s):  
Maria Giovanna Francipane ◽  
Mileidys Perez Alea ◽  
Ylenia Lombardo ◽  
Matilde Todaro ◽  
J.P. Medema ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Crucial Role ◽  
Interleukin 4 ◽  
Colon Cancer Stem Cells

Abstract 1714: The role of Hedgehog signaling in the regulation of human colon cancer stem cells

2016 ◽  
Author(s):  
Joseph L. Regan ◽  
Stephanie Staudte ◽  
Dirk Schumacher ◽  
Ulrich Keilholz ◽  
Johannes Haybaeck ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Hedgehog Signaling ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Stem Cells

The role of AP-1 in colon cancer stem cells.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14699-e14699
Author(s):  
Marina Chatziioannou ◽  
Panagiotis Apostolou ◽  
Maria Toloudi ◽  
Eleni Ioannou ◽  
Asir Kopic ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Colon Cancer ◽  
Transcription Factors ◽  
Cancer Stem Cells ◽  
The Other ◽  
Human Colon Cancer ◽  
Jnk Pathway ◽  
Colon Cancer Stem Cells

e14699 Background: The AP-1 transcription factor is a heterodimeric protein, which regulates gene expression in response to a variety of stimuli. The above factor also regulates cellular processes including differentiation, proliferation and apoptosis. The AP-1 heterodimeric protein is consisted of the combination of c-Jun and c-Fos proteins. The c-Jun is activated through phosphorylation, but it has also phosphorylation independent function. The c-FOS is a cellular proto-oncogene, which is up-regulated in response to many extracellular signals. The present study aim to find out the effect of c-FOS gene in Colon CSCs according to stemness. Methods: In all experiments there have been used established human colon cancer stem cells (CelProgen). Experiments for suppression of c-FOS expression, by using specific siRNA were performed and the transfection was evaluated with qPCR assays. The stemness transcription factors Nanog, Oct3/4 and Sox2 were tested with gene expression assays, and a relative quantification was performed according to Livak method. The CD44 and CD26 genes were used as positive markers in colon cancer in all procedures. Results: The results indicated that the c-FOS proto-oncogene affects the gene expression of transcription factors, which are essential for the maintenance of stemness. However the results were different, depending on the rate of suppression. The suppression of c-FOS by 65% led to increase in gene expression of stemness transcription factors, with higher rates for Nanog, smaller for Sox2 and minimum for Oct3/4. Unlike results were observed when the expression was suppressed by 85%. In this case there was observed higher decrease in Oct3/4 and less in the other markers. Conclusions: Up to now studies have demonstrated the significant role of c-JUN in stem cells, but little is known about the other half of AP-1 complex, the c-FOS gene. In the first part of the study it was confirmed the effect of c-FOS in stemness, as it was observed change in gene expression of stemness’s significant transcription factors. However it is indicated that there is a cross-talk between JNK pathway and stemness. Further studies in more samples are needed to demonstrate all the above, so that it can be used at clinical level.

OC.12.5 ROLE OF NITROGEN SPECIES IN COLON CANCER STEM CELLS

2013 ◽  
Vol 45 ◽  
pp. S82-S83
Author(s):  
M.A. Puglisi ◽  
V. Tesori ◽  
W. Lattanzi ◽  
E. Giorda ◽  
R. Carsetti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Nitrogen Species ◽  
Colon Cancer Stem Cells

Betulinic Acid Kills Colon Cancer Stem Cells

2016 ◽  
Vol 11 (5) ◽  
pp. 427-433 ◽  
Author(s):  
Lisette Potze ◽  
Simone di Franco ◽  
Jan H. Kessler ◽  
Giorgio Stassi ◽  
Jan Paul Medema
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Betulinic Acid ◽  
Colon Cancer Stem Cells

scholarly journals Aberrant expression of redox protein Ape1 in colon cancer stem cells

2014 ◽  
Vol 7 (4) ◽  
pp. 1078-1082 ◽  
Author(s):  
DEBAO LOU ◽  
LINA ZHU ◽  
HUAWEI DING ◽  
HAI-YAN DAI ◽  
GANG-MING ZOU
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Aberrant Expression ◽  
Redox Protein ◽  
Colon Cancer Stem Cells
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