scholarly journals Donor plasma mitochondrial DNA is associated with antibody-mediated rejection in renal allograft recipients

Aging ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 8440-8453
Author(s):  
Fei Han ◽  
Qipeng Sun ◽  
Zhengyu Huang ◽  
Heng Li ◽  
Maolin Ma ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Renal Allograft ◽  
Antibody Mediated Rejection ◽  
Donor Plasma

Donor Plasma Mitochondrial DNA Is Correlated with Posttransplant Renal Allograft Function

2019 ◽  
Vol 103 (11) ◽  
pp. 2347-2358 ◽  
Author(s):  
Fei Han ◽  
Shaogui Wan ◽  
Qipeng Sun ◽  
Nan Chen ◽  
Heng Li ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Renal Allograft ◽  
Allograft Function ◽  
Donor Plasma

scholarly journals B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Haiyan Xu ◽  
Xiaozhou He ◽  
Renfang Xu
Keyword(s):  
B Cell ◽  
Renal Allograft ◽  
Delayed Diagnosis ◽  
Clinical Manifestations ◽  
Direct Proof ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Antibody Mediated Rejection ◽  
B Cell Activating Factor

Antibody-mediated rejection (ABMR) of renal allograft lacks typical phenotypes and clinical manifestations, always resulting in delayed diagnosis and treatment. It has been considered to be an elemental factor influencing the improvement of the long-term outcome of renal allograft. The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. Data from recipients and the nonhuman primate ABMR model suggest that the BAFF signal participates in the ABMR of renal allograft, while there are objections. The challenges in the diagnosis of ABMR, different study population, and details of research may explain the discrepancy. Large quantities of dynamic, credible data of BAFF ligands and their association with renal allograft pathological characteristics would constitute a direct proof of the role of BAFF in the progression of renal allograft ABMR.

scholarly journals Banff lesions and renal allograft survival in chronic-active antibody mediated rejection

2019 ◽  
Vol 56 ◽  
pp. 101213 ◽  
Author(s):  
Kasia A. Sablik ◽  
Marian C. Clahsen- van Groningen ◽  
Jeffrey Damman ◽  
Dave L. Roelen ◽  
Michiel G.H. Betjes
Keyword(s):  
Renal Allograft ◽  
Allograft Survival ◽  
Antibody Mediated Rejection

scholarly journals Late Renal Allograft Rupture Associated with Cessation of Immunosuppression following Graft Failure

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Sumayah Askandarani ◽  
Noura Aloudah ◽  
Hanan Al Enazi ◽  
Khaled O. Alsaad ◽  
Abdulrahman Altamimi
Keyword(s):  
Graft Failure ◽  
Unusual Case ◽  
Renal Allograft ◽  
Time Interval ◽  
Antibody Mediated Rejection ◽  
Immunosuppressive Medications ◽  
Peritubular Capillaries ◽  
Long Time ◽  
Cellular Rejection ◽  
Marked Drop

A 29-year-old man developed chronic allograft nephropathy 63 months after renal transplantation. He became symptomatic with advanced chronic graft failure; his immunosuppressive medications were reduced and he was commenced on haemodialysis. Two months following the withdrawal of immunosuppression, he presented with abdominal pain, haematuria, and a marked drop in haemoglobin. The patient was taken to the operating room, where the renal allograft was found to be ruptured, and graft nephrectomy was subsequently performed. Histological examination of the graft specimen showed severe haemorrhagic acute vascular cellular rejection in a background of marked chronic allograft vasculopathy. Immunostaining for C4d showed diffuse, strong, linear circumferential staining of the peritubular capillaries, indicating a concurrent antibody-mediated rejection. We report herein an unusual case of spontaneous renal allograft rupture that occurred long time after transplantation due to severe acute rejection following cessation of immunosuppressive medications for advanced chronic allograft failure. To the best of our knowledge, the time interval between transplantation and the rupture of this allograft is the longest of those reported in the literature.

Clinical Significance of Macrophage Polarization in Antibody-Mediated Rejection of Renal Allograft

2018 ◽  
Vol 50 (4) ◽  
pp. 1005-1008 ◽  
Author(s):  
J. Kim ◽  
S.-E. Choi ◽  
B.J. Lim ◽  
Y.S. Kim ◽  
K.H. Huh ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Renal Allograft ◽  
Macrophage Polarization ◽  
Antibody Mediated Rejection
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