scholarly journals PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness

Aging ◽  
2021 ◽  
Author(s):  
Yi Yang ◽  
Lili Song ◽  
Xia Huang ◽  
Yanan Feng ◽  
Yingwen Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Pluripotent Stem Cell ◽  
Purine Biosynthesis ◽  
Stem Cell Survival

scholarly journals AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Leonardo Romorini ◽  
Ximena Garate ◽  
Gabriel Neiman ◽  
Carlos Luzzani ◽  
Verónica Alejandra Furmento ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Signaling Pathway ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Survival

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

scholarly journals Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons

2017 ◽  
Vol 26 (4) ◽  
pp. 613-624 ◽  
Author(s):  
Scott C. Vermilyea ◽  
Jianfeng Lu ◽  
Miles Olsen ◽  
Scott Guthrie ◽  
Yunlong Tao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Real Time ◽  
Pluripotent Stem Cell ◽  
Viral Vector ◽  
Induced Pluripotent Stem Cell ◽  
Cell Delivery ◽  
Intracerebral Injection ◽  
Induced Pluripotent

Induced pluripotent stem cell (iPSC)-derived neurons represent an opportunity for cell replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). Improvement in cell graft targeting, distribution, and density can be key for disease modification. We have previously developed a trajectory guide system for real-time intraoperative magnetic resonance imaging (RT-IMRI) delivery of infusates, such as viral vector suspensions for gene therapy strategies. Intracerebral delivery of iPSC-derived neurons presents different challenges than viral vectors, including limited cell survival if cells are kept at room temperature for prolonged periods of time, precipitation and aggregation of cells in the cannula, and obstruction during injection, which must be solved for successful application of this delivery approach. To develop procedures suitable for RT-IMRI cell delivery, we first performed in vitro studies to tailor the delivery hardware (e.g., cannula) and defined a range of parameters to be applied (e.g., maximal time span allowable between cell loading in the system and intracerebral injection) to ensure cell survival. Then we performed an in vivo study to evaluate the feasibility of applying the system to nonhuman primates. Our results demonstrate that the RT-IMRI delivery system provides valuable guidance, monitoring, and visualization during intracerebral cell delivery that are compatible with cell survival.

The enhancement of neural stem cell survival and growth by coculturing with expanded sertoli cells in vitro

2011 ◽  
Vol 28 (1) ◽  
pp. 196-205 ◽  
Author(s):  
Bingyang Shi ◽  
Lei Deng ◽  
Xiaolin Shi ◽  
Sheng Dai ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Neural Stem Cell ◽  
Sertoli Cells ◽  
Stem Cell Survival ◽  
Survival And Growth

Adult Stem Cell Survival Strategies

2012 ◽  
pp. 383-404 ◽  
Author(s):  
Melanie Rodrigues ◽  
Linda Griffith ◽  
Alan Wells
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Adult Stem Cell ◽  
Survival Strategies ◽  
Stem Cell Survival
Sign in / Sign up

Export Citation Format

Share Document