scholarly journals β-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: a randomized controlled trial

Aging ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 18660-18675
Author(s):  
Yasuhisa Ano ◽  
Keiko Kobayashi ◽  
Mamoru Hanyuda ◽  
Ryuta Kawashima
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Controlled Trial ◽  
Healthy Adults ◽  
Randomized Controlled ◽  
Dorsolateral Prefrontal

scholarly journals Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial

2021 ◽  
Vol 10 (3) ◽  
pp. 480
Author(s):  
Yasuhisa Ano ◽  
Masahiro Kita ◽  
Keiko Kobayashi ◽  
Takashi Koikeda ◽  
Ryuta Kawashima
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Regional Cerebral Blood Flow ◽  
Dorsolateral Prefrontal Cortex ◽  
Healthy Adults ◽  
Regional Cerebral Blood ◽  
Total Hemoglobin ◽  
Dorsolateral Prefrontal

Epidemiological studies have reported that consumption of dairy products rich in β-lactolin is beneficial for cognitive decline among elderly individuals. Although previous studies have shown that β-lactolin supplementation improves memory function and attention in healthy adults, the mechanism through which β-lactolin affects human brain function has yet to be elucidated. This placebo-controlled randomized double-blind study therefore examined the effects of β-lactolin on human regional cerebral blood flow (rCBF) using near-infrared spectroscopy (NIRS) according to the Consolidated Standards of Reporting Trials guidelines. A total of 114 healthy participants aged between 50 and 75 years with relatively low cognition were randomly allocated into the β-lactolin or placebo groups (n = 57 for both groups) and received supplementation for 6 weeks. After the 6 weeks of supplementation, total hemoglobin during cognitive tasks (Kraepelin and 2-back tasks) was measured using two-channel NIRS to determine rCBF. Accordingly, the β-lactolin group had significantly higher changes in total hemoglobin at the left dorsolateral prefrontal cortex (DLPFC) area measured using the left-side channel during the 2-back tasks (p = 0.027) compared to the placebo group. The present study suggests that β-lactolin supplementation increases rCBF and DLPFC activity during working memory tasks.

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