scholarly journals Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors

Aging ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 19628-19640
Author(s):  
Xiwen Qian ◽  
Huixun Jia ◽  
Yue Zhang ◽  
Bingqing Ma ◽  
Guoyou Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Metastatic Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Metastatic Breast ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Development of second primary cancers in breast cancer survivors.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 257-257
Author(s):  
Hong Kyu Jung ◽  
Jihyoun Lee ◽  
Zisun Kim ◽  
Min Hyuk Lee ◽  
Ilkyun Lee
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Thyroid Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Breast Cancer Patients ◽  
Second Primary Cancers

257 Background: Breast cancer survivors have slightly increased risk of second primary cancers. Importance of screening for second cancers has been raised due to increased survival in those populations. Not only having genetic risk such as BRCA mutation, but also treatment-related risk presents. The most common second primary cancer is breast cancer. Colon cancer, uterine cancer, and ovarian cancer showed increased cumulative incidence. In this study, we assessed development second primary cancers in breast cancer survivors. Methods: Medical record of breast cancer patients was reviewed retrospectively in three tertiary medical institutions. Available data of ICD-9 record after breast cancer diagnosis was evaluated. Diagnosis of second primary breast cancer was excluded in evaluation. Results: Since Jan 1989 to Jan 2014, available medical records were reviewed in breast cancer patients(N = 5880) in three institutions(one urban and the other two rural institutions). Cumulative incidence of overall second primary cancers was 4.57%. Among 269 second primary cancers, thyroid cancer(44.2%) was most common second primary cancer, followed by gastric cancer(10.0%). Gastric cancers were more common in rural institution than urban area(14.2 % vs 5.5%), while incidence of thyroid cancer is elevated in urban institution(57.8% vs 31.9%). Among 9 patients who has been diagnosed endometrial cancer, 7 patients had history of selective estrogen receptor modulator(tamoxifen or toremifen) treatment. Development of lung cancer was not related to breast cancer radiation treatment(4 of 15 patients). Leukemia after breast cancer treatment was diagnosed in 5 patients (8.5% of second primary cancers), three of them were adult T cell leukemia and two of them were acute myeloid leukemia. Conclusions: Incidence of cancer in general population was reflected to development of second primary cancer in breast cancer survivors. Endocrine treatment was related increased incidence of endometrial cancer, respectively. Application of personalized cancer screening plan would be important in this patient group.

scholarly journals Development of second primary cancer in Korean breast cancer survivors

2017 ◽  
Vol 93 (6) ◽  
pp. 287 ◽  
Author(s):  
Hong Kyu Jung ◽  
Suyeon Park ◽  
Nam Won Kim ◽  
Jong Eun Lee ◽  
Zisun Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Prediagnosis Smoking, Obesity, Insulin Resistance, and Second Primary Cancer Risk in Male Cancer Survivors: National Health Insurance Corporation Study

2007 ◽  
Vol 25 (30) ◽  
pp. 4835-4843 ◽  
Author(s):  
Sang Min Park ◽  
Min Kyung Lim ◽  
Kyu Won Jung ◽  
Soon Ae Shin ◽  
Keun-Young Yoo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Health Insurance ◽  
Cancer Survivors ◽  
National Health Insurance ◽  
National Health ◽  
Smoking History ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Purpose Smoking, obesity, and insulin resistance are well-known risk factors for cancer, yet few epidemiology studies evaluate their role as risk factors for a second primary cancer (SPC). Patients and Methods We identified 14,181 men with a first cancer from the National Health Insurance Corporation Study cohort. We obtained data on fasting glucose level, body mass index (BMI), and smoking history from an enrollment interview (1996). We obtained SPC incidence data for 1996 through 2002 from the Korean Central Cancer Registry. We used the standard Poisson regression model to estimate the age- and multivariate-adjusted relative risk (RR) for SPCs in relation to smoking history, BMI, and insulin resistance before diagnosis. Results We observed 204 patients with SPC. The overall age-standardized incidence rate of SPC was 603.2 occurrences per 100,000 person-years, which was about 2.3 times higher than that of first cancer in the general male population. Multivariate regression revealed that lung (RR, 3.69; 95% CI, 1.35 to 10.09) and smoking-related (RR, 2.02; 95% CI, 1.02 to 4.03) SPCs were significantly associated with smoking. Obese patients (BMI ≥ 25 kg/m2) had significantly elevated RRs for colorectal (RR, 3.45; 95% CI, 1.50 to 7.93) and genitourinary (RR, 3.61; 95% CI, 1.36 to 9.54) SPCs. Patients with a fasting serum glucose concentration ≥ 126 mg/dL had a higher RR for hepatopancreatobiliary (RR, 3.33; 95% CI, 1.33 to 8.37) and smoking-related (1.93; 95% CI, 1.01 to 3.68) SPCs. Conclusion Prediagnosis smoking history, obesity, and insulin resistance were risk factors for several SPCs. These findings suggest that more thorough surveillance and screening for SPCs is needed for the cancer survivors with these risk factors.

Risk factors for second primary tumours in breast cancer survivors

2008 ◽  
Vol 17 (5) ◽  
pp. 406-413 ◽  
Author(s):  
Luis Sánchez ◽  
Alberto Lana ◽  
Agustín Hidalgo ◽  
Jose María Rodríguez ◽  
María del Olivo Del Valle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Second Primary ◽  
Second Primary Tumours

scholarly journals Clinical and molecular analysis of long-term HER2 positive metastatic breast cancer survivors

2016 ◽  
Vol 27 ◽  
pp. vi84
Author(s):  
C. Omarini ◽  
C. Caprera ◽  
S. Manfredini ◽  
F. Caggia ◽  
G. Guaitoli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Survivors ◽  
Molecular Analysis ◽  
Breast Cancer Survivors ◽  
Metastatic Breast ◽  
Her2 Positive
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