scholarly journals The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2

Aging ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 20396-20412
Author(s):  
Weinan Xue ◽  
Fan Wang ◽  
Peng Han ◽  
Yanlong Liu ◽  
Bomiao Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Development

Serrated polyposis syndrome and the role of serrated polyps in colorectal cancer development

2012 ◽  
Vol 1 (1) ◽  
pp. 37-47
Author(s):  
Karam Singh Boparai ◽  
Yark Hazewinkel ◽  
Evelien Dekker
Keyword(s):  
Colorectal Cancer ◽  
Cancer Development ◽  
Polyposis Syndrome ◽  
Serrated Polyps

scholarly journals Role of mast cells in colorectal cancer development, the jury is still out

2012 ◽  
Vol 1822 (1) ◽  
pp. 9-13 ◽  
Author(s):  
J. Heijmans ◽  
N.V. Büller ◽  
V. Muncan ◽  
G.R. van den Brink
Keyword(s):  
Colorectal Cancer ◽  
Mast Cells ◽  
Cancer Development

scholarly journals Insights into the role of the intestinal microbiota in colon cancer

2017 ◽  
Vol 10 (5) ◽  
pp. 417-428 ◽  
Author(s):  
Sofia Oke ◽  
Alberto Martin
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Intestinal Microbiota ◽  
Drug Screening ◽  
Fungal Species ◽  
Cancer Development ◽  
Colorectal Cancers ◽  
Epithelial Tissue ◽  
Gut Homeostasis

The intestinal microbiota consists of a dynamic organization of bacteria, viruses, archaea, and fungal species essential for maintaining gut homeostasis and protecting the host against pathogenic invasion. When dysregulated, the intestinal microbiota can contribute to colorectal cancer development. Though the microbiota is multifaceted in its ability to induce colorectal cancer, this review will focus on the capability of the microbiota to induce colorectal cancer through the modulation of immune function and the production of microbial-derived metabolites. We will also explore an experimental technique that is revolutionizing intestinal research. By elucidating the interactions of microbial species with epithelial tissue, and allowing for drug screening of patients with colorectal cancers, organoid development is a novel culturing technique that is innovating intestinal research. As a cancer that remains one of the leading causes of cancer-related deaths worldwide, it is imperative that scientific findings are translated into the creation of effective therapeutics to treat colorectal cancer.

scholarly journals Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis

2016 ◽  
Vol 310 (11) ◽  
pp. G1081-G1090 ◽  
Author(s):  
Yvette J. Merga ◽  
Adrian O'Hara ◽  
Michael D. Burkitt ◽  
Carrie A. Duckworth ◽  
Christopher S. Probert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Signaling Pathway ◽  
Current Knowledge ◽  
Common Factor ◽  
Cancer Development ◽  
Gastrointestinal Malignancies ◽  
Activation Pathway ◽  
Inflammatory Bowel

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

scholarly journals The role of red and processed meat in colorectal cancer development: a perspective

Meat Science ◽  
2014 ◽  
Vol 97 (4) ◽  
pp. 583-596 ◽  
Author(s):  
Marije Oostindjer ◽  
Jan Alexander ◽  
Gro V. Amdam ◽  
Grethe Andersen ◽  
Nathan S. Bryan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Development ◽  
Processed Meat ◽  
Red And Processed Meat

Mo1662 The Role of SNPs of Genes Encoding Psca, MUC1 and PLCE1 in Gastritis, Gastric Cancer and Colorectal Cancer Development

2014 ◽  
Vol 146 (5) ◽  
pp. S-630
Author(s):  
Limas Kupcinskas ◽  
Alexander Link ◽  
Thomas Wex ◽  
Gediminas Kiudelis ◽  
Laimas Jonaitis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Development ◽  
Genes Encoding

scholarly journals The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

2021 ◽  
Vol 22 (23) ◽  
pp. 12739
Author(s):  
Sofía Frigerio ◽  
Dalia A. Lartey ◽  
Geert R. D’Haens ◽  
Joep Grootjans
Keyword(s):  
Colorectal Cancer ◽  
Immune System ◽  
Chronic Inflammation ◽  
Immune Cells ◽  
Checkpoint Inhibitors ◽  
Inflammatory Diseases ◽  
Cancer Development ◽  
Anti Inflammatory ◽  
Immunosuppressive Microenvironment

Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal epithelial changes, in which genetic mutations and molecular aberrations play a key role. IBD-associated cancer develops against a background of chronic inflammation and pro-inflammatory immune cells, and their products contribute to cancer development and progression. In recent years, the effect of the immunosuppressive microenvironment in cancer development and progression has gained more attention, mainly because of the unprecedented anti-tumor effects of immune checkpoint inhibitors in selected groups of patients. Even though IBD-associated cancer develops in the background of chronic inflammation which is associated with activation of endogenous anti-inflammatory or suppressive mechanisms, the potential role of an immunosuppressive microenvironment in these cancers is largely unknown. In this review, we outline the role of the immune system in promoting cancer development in chronic inflammatory diseases such as IBD, with a specific focus on the anti-inflammatory mechanisms and suppressive immune cells that may play a role in IBD-associated tumorigenesis.

scholarly journals The Association of Adiponectin and AdipoR1 Polymorphism rs1342387 in Some Obesity-related Cancers in Kurdistan Iraq

2021 ◽  
pp. 243-253
Author(s):  
Mahmood Khaleel ◽  
Shereen Al-Ali ◽  
Baker Shalal Habeeb
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Body Mass Index ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Significant Negative Correlation ◽  
Cancer Development ◽  
Healthy Controls ◽  
Medical Facilities

Background: Adiponectin (APN) is a novel hormone produced mainly by white adipose tissue that contribute to various physiological functions. APN has been related to cancer development specially the ones related to obesity such as breast cancer (BC) and colorectal cancer (CRC). Therefore, it also has been related body mass index (BMI). This study aims to investigate the role of APN and AdipoR1 polymorphism rs1342387 in some obesity-related cancer patients living in Erbil province (Kurdistan-Iraq). Method: The study includes 82 subjects (66 cancer patients, 16 healthy controls) from 4 medical facilities in Erbil, all participants were subjected to a questionnaire and signed a consent form before taking the samples. The serum level of APN was estimated by ELISA and the  AdipoR1 polymorphism (rs1342387) was detected by RFLP-PCR. Results: The results showed that the prevalence of BC cases were more than CRC cases. Furthermore, females were the dominant sex in BC. Moreover, the level of APN was significantly decreased in obesity-related cancer groups (BC, CRC) in compare to HC. Regarding APN correlation with BMI the results showed a weak non-significant negative correlation. The attempt to investigate the genotype of Kurdish people showed the frequency of GG genotype among Kurdish people but the recessive AA genotype showed more effects on decreasing the level of APN despite the non-significant results. Conclusion: This study is the first to investigate AdipoR1 polymorphism and its correlation to obesity-related cancers in Kurdistan-Iraq and although GG was the more frequent genotype, AA was more effective on APN levels in obesity-related cancers.

Role of Rho-Kinase Gene Polymorphisms and Protein Expressions in Colorectal Cancer Development

Pathobiology ◽  
2013 ◽  
Vol 80 (3) ◽  
pp. 138-145 ◽  
Author(s):  
Ibrahim Sari ◽  
Betul Berberoglu ◽  
Esma Ozkara ◽  
Serdar Oztuzcu ◽  
Celaletdin Camci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphisms ◽  
Rho Kinase ◽  
Cancer Development ◽  
Kinase Gene ◽  
Protein Expressions
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