scholarly journals S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

Aging ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 19254-19272
Author(s):  
Zhenxuan Shao ◽  
Zongyou Pan ◽  
Jialiang Lin ◽  
Qingqian Zhao ◽  
Yuqian Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Medial Meniscus ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Nrf2 Signaling Pathway ◽  
Meniscus Model

scholarly journals Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenxian Zhou ◽  
Yifeng Shi ◽  
Hui Wang ◽  
Caiyu Yu ◽  
Huanqing Zhu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Potential Candidate ◽  
Mtor Signaling Pathway ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

As a common degenerative disease, osteoarthritis (OA) usually causes disability in the elderly and socioeconomic burden. Previous studies have shown that proper autophagy has a protective effect on OA. Sinensetin (Sin) is a methylated flavonoid derived from citrus fruits. Studies have shown that Sin is a good autophagy inducer and has shown excellent therapeutic effects in a variety of diseases; however, its role in the treatment of OA is not fully understood. This study proved the protective effect of Sin on OA through a series of in vivo and in vitro experiments. In vitro experiments have shown that Sin may inhibit chondrocyte apoptosis induced by tert-butyl hydroperoxide (TBHP); at the same time, it might also inhibit the production of MMP13 and promote the production of aggrecan and collagen II. Mechanism studies have shown that Sin promotes chondrocyte autophagy by activating AMPK/mTOR signaling pathway. On the contrary, inhibition of autophagy can partially abolish the protective effect of Sin on TBHP-treated chondrocytes. In vivo experiments show that Sin may protect against DMM-induced OA pathogenesis. These results provide evidence that Sin serves as a potential candidate for the treatment of OA.

Tetrabutylammonium Iodide Catalyzed Synthesis of Allylic Ester with tert-Butyl Hydroperoxide as an Oxidant

2012 ◽  
Vol 14 (13) ◽  
pp. 3384-3387 ◽  
Author(s):  
Erbo Shi ◽  
Ying Shao ◽  
Shulin Chen ◽  
Huayou Hu ◽  
Zhaojun Liu ◽  
...  
Keyword(s):  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Tetrabutylammonium Iodide

Coupling of torsion and OH-stretching in tert-butyl hydroperoxide. I. The cold and warm first OH-stretching overtone spectrum

2021 ◽  
Vol 154 (16) ◽  
pp. 164306
Author(s):  
Anne S. Hansen ◽  
Rachel M. Huchmala ◽  
Emil Vogt ◽  
Mark A. Boyer ◽  
Trisha Bhagde ◽  
...  
Keyword(s):  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide
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