scholarly journals An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients

Aging ◽  
2020 ◽  
Vol 12 (15) ◽  
pp. 15624-15637 ◽  
Author(s):  
Zhuolun Sun ◽  
Changying Jing ◽  
Chutian Xiao ◽  
Tengcheng Li
Keyword(s):  
Urothelial Carcinoma ◽  
Survival Outcomes ◽  
Prognostic Signature ◽  
Non Coding Rna ◽  
Bladder Urothelial Carcinoma ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA MEG3 suppresses the development of bladder urothelial carcinoma by regulating miR-96 and TPM1

2018 ◽  
Vol 19 (11) ◽  
pp. 1039-1056 ◽  
Author(s):  
Guanghua Liu ◽  
Xin Zhao ◽  
Jingmin Zhou ◽  
Xiangming Cheng ◽  
Zixing Ye ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Non Coding Rna ◽  
Bladder Urothelial Carcinoma ◽  
Long Non Coding Rna

scholarly journals LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Shicai Ye ◽  
Bilan Sun ◽  
Weiyun Wu ◽  
Caiyuan Yu ◽  
Ting Tian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Colon Adenocarcinoma ◽  
Colon Cancer Cells ◽  
Prognostic Signature ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Colon Cancer Progression ◽  
Long Non Coding Rna

Abstract Colon cancer is one of the major causes of cancer-related deaths worldwide. Long non-coding RNA (lncRNA) LINC01123 has been suggested to act as an oncogene in non-small cell lung cancer and a prognostic signature in head and neck squamous cell carcinoma. However, its role in colon cancer remains obscure. From TCGA database, LINC01123 was observed to be up-regulated in colon adenocarcinoma (COAD). Subsequently, the up-regulated LINC01123 was also detected in colon cancer cells. Functionally, LINC01123 could enhance cell proliferation, migration, invasion and angiogenesis. Moreover, the chemoresistance of colon cancer cells was verified to be promoted by LINC01123. Afterward, LINC01123 was found to bind with Ago2 and miR-34c-5p. Besides, miR-34c-5p was confirmed to inhibit the cellular process and chemoresistance of colon cancer cells. Then, VEGFA was disclosed to coexist with LINC01123 and miR-34c-5p in RNA-induced silencing complex. And TCGA database suggested that its expression was correlated with different stages of COAD. Moreover, it was uncovered that VEGFA could bind with miR-34c-5p and its expression positively correlated with LINC01123 expression. Finally, LINC01123 was proofed to regulate colon cancer progression and cells chemoresistance via VEGFA. In conclusion, LINC01123/miR-34c-5p/VEGFA axis promotes colon cancer malignancy and cells chemoresistance.

scholarly journals Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells

2014 ◽  
Vol 32 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
XIUJUAN WANG ◽  
YANBING GONG ◽  
BO JIN ◽  
CHENGLIN WU ◽  
JIANMING YANG ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Cell Replication ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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