scholarly journals Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging

Aging ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 12648-12668
Author(s):  
Ramy K. A. Sayed ◽  
Doaa M. Mokhtar ◽  
Marisol Fernández-Ortiz ◽  
José Fernández-Martínez ◽  
Paula Aranda-Martínez ◽  
...  
Keyword(s):  
Orphan Receptor ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoid Acid ◽  
Testicular Aging

scholarly journals Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα

2016 ◽  
Vol 80 ◽  
pp. 17-23 ◽  
Author(s):  
Lei Xiao ◽  
Zihui Zhang ◽  
Xiaoqin Luo ◽  
Haixia Yang ◽  
Fan Li ◽  
...  
Keyword(s):  
Orphan Receptor ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
M2 Polarization ◽  
Retinoid Acid

scholarly journals Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60111 ◽  
Author(s):  
Nathalie Acevedo ◽  
Annika Sääf ◽  
Cilla Söderhäll ◽  
Erik Melén ◽  
Jami Mandelin ◽  
...  
Keyword(s):  
Orphan Receptor ◽  
Neuropeptide S ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoid Acid

scholarly journals Thiazolidine Diones, Specific Ligands of the Nuclear Receptor Retinoid Z Receptor/Retinoid Acid Receptor-related Orphan Receptor α with Potent Antiarthritic Activity

1996 ◽  
Vol 271 (23) ◽  
pp. 13515-13522 ◽  
Author(s):  
Martin Missbach ◽  
Bruno Jagher ◽  
Ivo Sigg ◽  
Sepideh Nayeri ◽  
Carsten Carlberg ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Orphan Receptor ◽  
Acid Receptor ◽  
Retinoid Acid

Tu-P8:314 Transcriptional regulation of retinoic acid receptor-related orphan receptor alpha 4

2006 ◽  
Vol 7 (3) ◽  
pp. 254
Author(s):  
F. Osaki ◽  
H. Takata ◽  
T. Suehiro ◽  
M. Inoue ◽  
K. Arii ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Orphan Receptor ◽  
Acid Receptor ◽  
Receptor Alpha

scholarly journals Trastuzumab treatment in human breast cancer is associated with over-expression of the retinoic acid receptor alpha (RARA).

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Human Breast Cancer ◽  
Retinoic Acid Receptor ◽  
Human Breast ◽  
Retinoic Acid Receptor Alpha ◽  
Primary Tumors ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoid Acid

Treatment with trastuzumab has been associated with an increased risk of central nervous system metastasis in patients with human breast cancer (1-5). We performed unbiased transcriptome profiling of primary tumors of patients treated with trastuzumab using published microarray and multiplexed gene expression datasets (6, 7) to understand the transcriptional makeup of breast tumors in the trastuzumab-treated patients. We found that the retinoid acid receptor alpha was among the genes most differentially expressed in the primary tumors of patients treated with trastuzumab; retinoid acid receptor alpha was expressed at significantly higher levels in tumors from patients with trastuzumab as compared to those not treated with trastuzumab. Increased retinoic acid receptor alpha expression is known to confer tamoxifen resistance to human breast cancers (8), and RARA expression is higher in tumors with higher proliferative capacity (9), suggesting that trastuzumab could contribute to resistance to endocrine therapy.

Sign in / Sign up

Export Citation Format

Share Document